ID   OLA1_DANRE              Reviewed;         396 AA.
AC   Q7ZU42;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Obg-like ATPase 1 {ECO:0000255|HAMAP-Rule:MF_03167};
GN   Name=ola1; ORFNames=zgc:55768;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB; TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Hydrolyzes ATP, and can also hydrolyze GTP with lower
CC       efficiency. Has lower affinity for GTP. {ECO:0000255|HAMAP-
CC       Rule:MF_03167}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC   -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_03167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03167}.
CC       Nucleus {ECO:0000255|HAMAP-Rule:MF_03167}. Nucleus, nucleolus
CC       {ECO:0000255|HAMAP-Rule:MF_03167}. Note=Predominantly cytoplasmic,
CC       shuttles between the nucleus and the cytoplasm. {ECO:0000255|HAMAP-
CC       Rule:MF_03167}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class OBG-HflX-like GTPase
CC       superfamily. OBG GTPase family. YchF/OLA1 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_03167}.
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DR   EMBL; BC051155; AAH51155.1; -; mRNA.
DR   EMBL; BC067579; AAH67579.1; -; mRNA.
DR   RefSeq; NP_999865.1; NM_214700.2.
DR   AlphaFoldDB; Q7ZU42; -.
DR   SMR; Q7ZU42; -.
DR   STRING; 7955.ENSDARP00000045298; -.
DR   PaxDb; Q7ZU42; -.
DR   PRIDE; Q7ZU42; -.
DR   Ensembl; ENSDART00000045299; ENSDARP00000045298; ENSDARG00000044565.
DR   GeneID; 326864; -.
DR   KEGG; dre:326864; -.
DR   CTD; 29789; -.
DR   ZFIN; ZDB-GENE-030131-5063; ola1.
DR   eggNOG; KOG1491; Eukaryota.
DR   GeneTree; ENSGT00390000000673; -.
DR   InParanoid; Q7ZU42; -.
DR   OMA; DFHDLCE; -.
DR   OrthoDB; 738371at2759; -.
DR   PhylomeDB; Q7ZU42; -.
DR   TreeFam; TF300774; -.
DR   Reactome; R-DRE-114608; Platelet degranulation.
DR   PRO; PR:Q7ZU42; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 6.
DR   Bgee; ENSDARG00000044565; Expressed in presomitic mesoderm and 30 other tissues.
DR   ExpressionAtlas; Q7ZU42; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0043022; F:ribosome binding; IEA:UniProtKB-UniRule.
DR   CDD; cd04867; TGS_YchF_OLA1; 1.
DR   CDD; cd01900; YchF; 1.
DR   Gene3D; 1.10.150.300; -; 1.
DR   Gene3D; 3.10.20.30; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00944; YchF_OLA1_ATPase; 1.
DR   InterPro; IPR004396; ATPase_YchF/OLA1.
DR   InterPro; IPR012675; Beta-grasp_dom_sf.
DR   InterPro; IPR031167; G_OBG.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR004095; TGS.
DR   InterPro; IPR012676; TGS-like.
DR   InterPro; IPR023192; TGS-like_dom_sf.
DR   InterPro; IPR013029; YchF_C.
DR   InterPro; IPR041706; YchF_N.
DR   Pfam; PF01926; MMR_HSR1; 1.
DR   Pfam; PF06071; YchF-GTPase_C; 1.
DR   PIRSF; PIRSF006641; CHP00092; 1.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF81271; SSF81271; 1.
DR   TIGRFAMs; TIGR00092; TIGR00092; 1.
DR   PROSITE; PS51710; G_OBG; 1.
DR   PROSITE; PS51880; TGS; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cytoplasm; Hydrolase; Magnesium; Metal-binding;
KW   Nucleotide-binding; Nucleus; Reference proteome.
FT   CHAIN           1..396
FT                   /note="Obg-like ATPase 1"
FT                   /id="PRO_0000354700"
FT   DOMAIN          23..283
FT                   /note="OBG-type G"
FT   DOMAIN          304..387
FT                   /note="TGS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01228"
FT   MOTIF           267..274
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03167"
FT   BINDING         32..37
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03167"
FT   BINDING         36
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         56
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         231
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03167"
SQ   SEQUENCE   396 AA;  44902 MW;  E15AB258DC362B64 CRC64;
     MPPKKGGDGP KQPPLIGRFG TSLKIGIVGL PNVGKSTFFN VLTKSQAAAE NFPFCTIDPN
     ESRVPIPDER FDFLCQYHKP ASKVPAFLNV VDIAGLVKGA HAGQGLGNAF LSNIFACDAI
     FHMTRAFEDE DIIHVEGCVD PVRDIEIIHE ELRMKDEEMI GPIIDKLEKT AVRGGDKKLK
     PEYDIMCKVK SWVVDEKKHV RYYHEWNDKE IEVLNKHLFL TSKPMIYLVN LSEKDYIRKK
     NKWLVKIKEW VDAHDPGALV IPLSGGFESK YQDMSDEEKQ KYCEENKTQS ILTKIIKSGY
     SALQLEYFFT AGPDEVRAWT VRKGTKAPQA AGKIHTDFEK GFIMAEVMKF TDFKEEGSEN
     AAKAAGKYRQ QGRNYIVEDG DIIFFKFNTP NQPKKK