ID   OLA1_XENTR              Reviewed;         396 AA.
AC   Q66JG0; Q28HH3;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Obg-like ATPase 1 {ECO:0000255|HAMAP-Rule:MF_03167};
GN   Name=ola1; ORFNames=TTpA007h13.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tadpole;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Hydrolyzes ATP, and can also hydrolyze GTP with lower
CC       efficiency. Has lower affinity for GTP. {ECO:0000255|HAMAP-
CC       Rule:MF_03167}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC   -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_03167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03167}.
CC       Nucleus {ECO:0000255|HAMAP-Rule:MF_03167}. Nucleus, nucleolus
CC       {ECO:0000255|HAMAP-Rule:MF_03167}. Note=Predominantly cytoplasmic,
CC       shuttles between the nucleus and the cytoplasm. {ECO:0000255|HAMAP-
CC       Rule:MF_03167}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class OBG-HflX-like GTPase
CC       superfamily. OBG GTPase family. YchF/OLA1 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_03167}.
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DR   EMBL; CR760885; CAJ83205.1; -; mRNA.
DR   EMBL; BC080929; AAH80929.1; -; mRNA.
DR   RefSeq; NP_001008044.1; NM_001008043.1.
DR   AlphaFoldDB; Q66JG0; -.
DR   SMR; Q66JG0; -.
DR   STRING; 8364.ENSXETP00000018601; -.
DR   PaxDb; Q66JG0; -.
DR   DNASU; 493406; -.
DR   GeneID; 493406; -.
DR   KEGG; xtr:493406; -.
DR   CTD; 29789; -.
DR   Xenbase; XB-GENE-1015258; ola1.
DR   eggNOG; KOG1491; Eukaryota.
DR   HOGENOM; CLU_018395_1_0_1; -.
DR   InParanoid; Q66JG0; -.
DR   OrthoDB; 738371at2759; -.
DR   PhylomeDB; Q66JG0; -.
DR   TreeFam; TF300774; -.
DR   Reactome; R-XTR-114608; Platelet degranulation.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0043022; F:ribosome binding; IEA:UniProtKB-UniRule.
DR   CDD; cd04867; TGS_YchF_OLA1; 1.
DR   CDD; cd01900; YchF; 1.
DR   Gene3D; 1.10.150.300; -; 1.
DR   Gene3D; 3.10.20.30; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00944; YchF_OLA1_ATPase; 1.
DR   InterPro; IPR004396; ATPase_YchF/OLA1.
DR   InterPro; IPR012675; Beta-grasp_dom_sf.
DR   InterPro; IPR031167; G_OBG.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR004095; TGS.
DR   InterPro; IPR012676; TGS-like.
DR   InterPro; IPR023192; TGS-like_dom_sf.
DR   InterPro; IPR013029; YchF_C.
DR   InterPro; IPR041706; YchF_N.
DR   Pfam; PF01926; MMR_HSR1; 1.
DR   Pfam; PF06071; YchF-GTPase_C; 1.
DR   PIRSF; PIRSF006641; CHP00092; 1.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF81271; SSF81271; 1.
DR   TIGRFAMs; TIGR00092; TIGR00092; 1.
DR   PROSITE; PS51710; G_OBG; 1.
DR   PROSITE; PS51880; TGS; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cytoplasm; Hydrolase; Magnesium; Metal-binding;
KW   Nucleotide-binding; Nucleus; Reference proteome.
FT   CHAIN           1..396
FT                   /note="Obg-like ATPase 1"
FT                   /id="PRO_0000354702"
FT   DOMAIN          23..283
FT                   /note="OBG-type G"
FT   DOMAIN          304..387
FT                   /note="TGS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01228"
FT   MOTIF           267..274
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03167"
FT   BINDING         32..37
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03167"
FT   BINDING         36
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         56
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         231
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03167"
FT   CONFLICT        254
FT                   /note="Y -> H (in Ref. 1; CAJ83205)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   396 AA;  45006 MW;  62F0C2295057488B CRC64;
     MPPKKADDGP KQHPIIGRFG TSLKIGIVGL PNIGKSTFFN VLTKSQAAAE NFPFCTINPN
     ESRVPVPDER FEFLCQYHKP ASKVPAFLNV VDIAGLVKGA STGQGLGNAF LSNISACDGI
     FHLMRAFDDD DIIHVEGSVN PVRDIEIIHE ELRLKDEEMI IAALDKLEKV AVRGGDKKLK
     PEYDIMCKVK NWIIDEKNHV RFYHDWNDKE IDVLNKYLFL TSKPMIYLVN LSEKDYIRKK
     NKWLIKIKEW VDKYDPCALV IPFSGVLELN LQDMSDEEKH KYLQEKVTQS VLSKIVKTGY
     AALQLEYFFT AGPDEVRAWT IKKGTKAPQA AGKIHTDFEK GFIMAEVMKF DDFKEEGSES
     SVKAAGKYRQ QGRNYTVEDG DIIFFKFNTP QQSKKK