ID   OLE13_CORAV             Reviewed;         140 AA.
AC   Q84T91;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=Oleosin Cor a 13 {ECO:0000303|PubMed:34146442};
DE   AltName: Allergen=Cor a 13 {ECO:0000303|PubMed:34146442};
OS   Corylus avellana (European hazel) (Corylus maxima).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fagales; Betulaceae; Corylus.
OX   NCBI_TaxID=13451 {ECO:0000312|EMBL:AAO65960.1};
RN   [1] {ECO:0000312|EMBL:AAO65960.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=16288502; DOI=10.1002/mnfr.200500147;
RA   Akkerdaas J.H., Schocker F., Vieths S., Versteeg S., Zuidmeer L.,
RA   Hefle S.L., Aalberse R.C., Richter K., Ferreira F., van Ree R.;
RT   "Cloning of oleosin, a putative new hazelnut allergen, using a hazelnut
RT   cDNA library.";
RL   Mol. Nutr. Food Res. 50:18-23(2006).
RN   [2] {ECO:0000305}
RP   MASS SPECTROMETRY, AND ALLERGEN.
RX   PubMed=34146442; DOI=10.1111/pai.13579;
RA   Nebbia S., Lamberti C., Cirrincione S., Acquadro A., Abba S., Ciuffo M.,
RA   Torello Marinoni D., Manfredi M., Marengo E., Calzedda R., Monti G.,
RA   Cavallarin L., Giuffrida M.G.;
RT   "Oleosin Cor a 15 is a novel allergen for Italian hazelnut allergic
RT   children.";
RL   Pediatr. Allergy Immunol. 32:1743-1755(2021).
CC   -!- FUNCTION: May have a structural role to stabilize the lipid body during
CC       desiccation of the seed by preventing coalescence of the oil. Probably
CC       interacts with both lipid and phospholipid moieties of lipid bodies.
CC       May also provide recognition signals for specific lipase anchorage in
CC       lipolysis during seedling growth. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Lipid droplet {ECO:0000250|UniProtKB:O04925}.
CC       Membrane {ECO:0000255|RuleBase:RU000540}; Multi-pass membrane protein
CC       {ECO:0000255|RuleBase:RU000540}. Note=Surface of oil bodies. Oleosins
CC       exist at a monolayer lipid/water interface. {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in seeds. {ECO:0000269|PubMed:16288502}.
CC   -!- MASS SPECTROMETRY: Mass=14000; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:34146442};
CC   -!- ALLERGEN: Causes an allergic reaction in human (PubMed:34146442). Binds
CC       to IgE of patients allergic to hazelnuts (PubMed:34146442).
CC       {ECO:0000269|PubMed:34146442}.
CC   -!- SIMILARITY: Belongs to the oleosin family. {ECO:0000305}.
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DR   EMBL; AY224599; AAO65960.1; -; mRNA.
DR   Allergome; 5765; Cor a 13.
DR   Allergome; 5766; Cor a 13.0101.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0012511; C:monolayer-surrounded lipid storage body; IEA:InterPro.
DR   GO; GO:0022414; P:reproductive process; IEA:UniProt.
DR   InterPro; IPR000136; Oleosin.
DR   PANTHER; PTHR33203; PTHR33203; 1.
DR   Pfam; PF01277; Oleosin; 1.
DR   PROSITE; PS00811; OLEOSINS; 1.
PE   1: Evidence at protein level;
KW   Allergen; Lipid droplet; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..140
FT                   /note="Oleosin Cor a 13"
FT                   /id="PRO_0000456212"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   140 AA;  14732 MW;  1AC8683A6205C4A0 CRC64;
     MAEHPRQLQD PAHQPRSHQV VKAATAATAG GSLLVPSGLI LAGTVIALTL ATPLFVIFSP
     VLVPAVITVS LIIMGFLASG GFGVAAVTVL SWIYRYVTGR HPPGADQLDH ARMKLASKAR
     EMKDRAEQFG QQHVTGSQGS