ID   OLE15_CORAV             Reviewed;         169 AA.
AC   C0HM28;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   03-AUG-2022, sequence version 1.
DT   03-AUG-2022, entry version 1.
DE   RecName: Full=Oleosin Cor a 15 {ECO:0000303|PubMed:34146442};
DE   AltName: Allergen=Cor a 15 {ECO:0000303|PubMed:34146442};
OS   Corylus avellana (European hazel) (Corylus maxima).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fagales; Betulaceae; Corylus.
OX   NCBI_TaxID=13451 {ECO:0000312|EMBL:QEM21451.1};
RN   [1] {ECO:0000312|EMBL:QEM21451.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-12, FUNCTION, TISSUE
RP   SPECIFICITY, MASS SPECTROMETRY, AND ALLERGEN.
RX   PubMed=34146442; DOI=10.1111/pai.13579;
RA   Nebbia S., Lamberti C., Cirrincione S., Acquadro A., Abba S., Ciuffo M.,
RA   Torello Marinoni D., Manfredi M., Marengo E., Calzedda R., Monti G.,
RA   Cavallarin L., Giuffrida M.G.;
RT   "Oleosin Cor a 15 is a novel allergen for Italian hazelnut allergic
RT   children.";
RL   Pediatr. Allergy Immunol. 32:1743-1755(2021).
CC   -!- FUNCTION: May have a structural role to stabilize the lipid body during
CC       desiccation of the seed by preventing coalescence of the oil. Probably
CC       interacts with both lipid and phospholipid moieties of lipid bodies.
CC       May also provide recognition signals for specific lipase anchorage in
CC       lipolysis during seedling growth. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Lipid droplet {ECO:0000250|UniProtKB:O04925}.
CC       Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
CC       Note=Surface of oil bodies. Oleosins exist at a monolayer lipid/water
CC       interface. {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in seeds (at protein level).
CC       {ECO:0000269|PubMed:34146442}.
CC   -!- DOMAIN: The proline-knot motif may be involved in the targeting to oil
CC       bodies. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=17000; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:34146442};
CC   -!- ALLERGEN: Causes an allergic reaction in human (PubMed:34146442). Binds
CC       to IgE in 88% of the hazelnut-allergic patients tested
CC       (PubMed:34146442). {ECO:0000269|PubMed:34146442}.
CC   -!- SIMILARITY: Belongs to the oleosin family.
CC       {ECO:0000255|RuleBase:RU000540}.
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DR   EMBL; MK737923; QEM21451.1; -; mRNA.
PE   1: Evidence at protein level;
KW   Allergen; Direct protein sequencing; Lipid droplet; Membrane;
KW   Transmembrane; Transmembrane helix.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000305"
FT   CHAIN           2..169
FT                   /note="Oleosin Cor a 15"
FT                   /id="PRO_0000456215"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           70..81
FT                   /note="Proline-knot"
FT                   /evidence="ECO:0000250|UniProtKB:O04925"
SQ   SEQUENCE   169 AA;  17695 MW;  80F46E4CC4B71570 CRC64;
     MADYQHQQQH QRPADAFKGM FPEKGQAQVQ GPSASKVIAV VTLLPLGGFL LLLAGLTFAG
     TLIGLALSTP LFVLCSPVLV PAAIVIGLAV TGFLTSGAFG ITGISSLSWI LKYLRGTSVP
     EQMEHAKRRA QDTAGHLGQK ARETGQTVTG KGQEAGKTLE GGRGEEKKT