OLED_STRAT
ID OLED_STRAT Reviewed; 430 AA.
AC Q53685;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Oleandomycin glycosyltransferase;
DE EC=2.4.1.-;
GN Name=oleD; Synonyms=UGT102A2;
OS Streptomyces antibioticus.
OC Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC Streptomyces.
OX NCBI_TaxID=1890;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 11891 / DSM 40868 / BCRC 11580 / NCIMB 11506 / PSA 205;
RX PubMed=8244027; DOI=10.1016/0378-1119(93)90189-a;
RA Hernandez C., Olano C., Mendez C., Salas J.A.;
RT "Characterization of a Streptomyces antibioticus gene cluster encoding a
RT glycosyltransferase involved in oleandomycin inactivation.";
RL Gene 134:139-140(1993).
CC -!- FUNCTION: Specifically inactivates oleandomycin via 2'-O-glycosylation
CC using UDP-glucose.
CC -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC {ECO:0000305}.
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DR EMBL; Z22577; CAA80301.1; -; Genomic_DNA.
DR PIR; S33184; S33184.
DR PDB; 2IYF; X-ray; 1.70 A; A/B=1-413.
DR PDB; 4M60; X-ray; 1.77 A; A=1-413.
DR PDB; 4M7P; X-ray; 1.77 A; A=1-413.
DR PDB; 4M83; X-ray; 1.70 A; A/B=1-413.
DR PDBsum; 2IYF; -.
DR PDBsum; 4M60; -.
DR PDBsum; 4M7P; -.
DR PDBsum; 4M83; -.
DR AlphaFoldDB; Q53685; -.
DR SMR; Q53685; -.
DR ChEMBL; CHEMBL3308957; -.
DR CAZy; GT1; Glycosyltransferase Family 1.
DR PRIDE; Q53685; -.
DR KEGG; ag:CAA80301; -.
DR BioCyc; MetaCyc:MON-17058; -.
DR EvolutionaryTrace; Q53685; -.
DR GO; GO:0016758; F:hexosyltransferase activity; IEA:InterPro.
DR GO; GO:0008194; F:UDP-glycosyltransferase activity; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd03784; GT1_Gtf-like; 1.
DR InterPro; IPR002213; UDP_glucos_trans.
DR InterPro; IPR035595; UDP_glycos_trans_CS.
DR InterPro; IPR006326; UDPGT_MGT-like.
DR Pfam; PF00201; UDPGT; 1.
DR TIGRFAMs; TIGR01426; MGT; 1.
DR PROSITE; PS00375; UDPGT; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Antibiotic resistance; Glycosyltransferase; Transferase.
FT CHAIN 1..430
FT /note="Oleandomycin glycosyltransferase"
FT /id="PRO_0000074165"
FT REGION 385..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..430
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT STRAND 9..13
FT /evidence="ECO:0007829|PDB:4M83"
FT HELIX 18..20
FT /evidence="ECO:0007829|PDB:4M83"
FT HELIX 22..24
FT /evidence="ECO:0007829|PDB:4M83"
FT HELIX 25..34
FT /evidence="ECO:0007829|PDB:4M83"
FT STRAND 37..42
FT /evidence="ECO:0007829|PDB:4M83"
FT HELIX 44..46
FT /evidence="ECO:0007829|PDB:4M83"
FT HELIX 47..51
FT /evidence="ECO:0007829|PDB:4M83"
FT TURN 52..54
FT /evidence="ECO:0007829|PDB:4M60"
FT STRAND 56..59
FT /evidence="ECO:0007829|PDB:4M83"
FT STRAND 67..69
FT /evidence="ECO:0007829|PDB:4M83"
FT HELIX 71..74
FT /evidence="ECO:0007829|PDB:4M83"
FT HELIX 78..101
FT /evidence="ECO:0007829|PDB:4M83"
FT STRAND 106..111
FT /evidence="ECO:0007829|PDB:4M83"
FT HELIX 115..124
FT /evidence="ECO:0007829|PDB:4M83"
FT STRAND 128..134
FT /evidence="ECO:0007829|PDB:4M83"
FT HELIX 141..144
FT /evidence="ECO:0007829|PDB:4M83"
FT HELIX 146..154
FT /evidence="ECO:0007829|PDB:4M83"
FT HELIX 157..172
FT /evidence="ECO:0007829|PDB:4M83"
FT HELIX 179..184
FT /evidence="ECO:0007829|PDB:4M83"
FT STRAND 187..191
FT /evidence="ECO:0007829|PDB:4M83"
FT HELIX 195..197
FT /evidence="ECO:0007829|PDB:4M83"
FT HELIX 201..203
FT /evidence="ECO:0007829|PDB:4M83"
FT TURN 206..208
FT /evidence="ECO:0007829|PDB:4M83"
FT STRAND 209..211
FT /evidence="ECO:0007829|PDB:4M83"
FT STRAND 232..237
FT /evidence="ECO:0007829|PDB:4M83"
FT TURN 240..242
FT /evidence="ECO:0007829|PDB:2IYF"
FT HELIX 247..257
FT /evidence="ECO:0007829|PDB:4M83"
FT STRAND 263..268
FT /evidence="ECO:0007829|PDB:4M83"
FT STRAND 271..273
FT /evidence="ECO:0007829|PDB:2IYF"
FT HELIX 275..278
FT /evidence="ECO:0007829|PDB:2IYF"
FT STRAND 285..289
FT /evidence="ECO:0007829|PDB:4M83"
FT HELIX 293..297
FT /evidence="ECO:0007829|PDB:4M83"
FT STRAND 301..305
FT /evidence="ECO:0007829|PDB:4M83"
FT HELIX 309..317
FT /evidence="ECO:0007829|PDB:4M83"
FT STRAND 322..324
FT /evidence="ECO:0007829|PDB:4M83"
FT HELIX 329..331
FT /evidence="ECO:0007829|PDB:2IYF"
FT HELIX 332..340
FT /evidence="ECO:0007829|PDB:4M83"
FT STRAND 343..346
FT /evidence="ECO:0007829|PDB:4M83"
FT TURN 349..351
FT /evidence="ECO:0007829|PDB:4M60"
FT HELIX 354..365
FT /evidence="ECO:0007829|PDB:4M83"
FT HELIX 368..384
FT /evidence="ECO:0007829|PDB:4M83"
FT HELIX 387..397
FT /evidence="ECO:0007829|PDB:4M83"
SQ SEQUENCE 430 AA; 47136 MW; 320512217B42A0B7 CRC64;
MTTQTTPAHI AMFSIAAHGH VNPSLEVIRE LVARGHRVTY AIPPVFADKV AATGPRPVLY
HSTLPGPDAD PEAWGSTLLD NRRTFLNDAI QALPQLADAY ADDIPDLVLH DITSYPARVL
ARRWGVPAVS LSPNLVAWKG YEEEVAEPMW REPRQTERGR AYYARFEAWL KENGITEHPD
TFASHPPRSL VLIPKALQPH ADRVDEDVYT FVGACQGDRA EEGGWQRPAG AEKVVLVSLG
SAFTKQPAFY RECVRAFGNL PGWHLVLQIG RKVTPAELGE LPDNVEVHDW VPQLAILRQA
DLFVTHAGAG GSQEGLATAT PMIAVPQAVD QFGNADMLQG LGVARKLATE EATADLLRET
ALALVDDPEV ARRLRRIQAE MAQEGGTRRA ADLIEAELPA RHERQEPVGD RPNVGDRPAG
VRSDRQRSAL
