OLF11_MOUSE
ID OLF11_MOUSE Reviewed; 313 AA.
AC Q60890; Q7TQU3; Q8VFH1;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Olfactory receptor 11;
DE AltName: Full=Odorant receptor M49;
DE AltName: Full=Olfactory receptor 256-11;
GN Name=Olfr11; Synonyms=Mor256-11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [3]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14611657; DOI=10.1186/gb-2003-4-11-r71;
RA Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A.,
RA Walker M., Williams E.M., Trask B.J.;
RT "Odorant receptor expressed sequence tags demonstrate olfactory expression
RT of over 400 genes, extensive alternate splicing and unequal expression
RT levels.";
RL Genome Biol. 4:R71.1-R71.13(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 128-239.
RC STRAIN=C57BL/6J;
RX PubMed=8570653; DOI=10.1073/pnas.93.2.884;
RA Sullivan S.L., Adamson M.C., Ressler K.J., Kozak C.A., Buck L.B.;
RT "The chromosomal distribution of mouse odorant receptor genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:884-888(1996).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY073555; AAL61218.1; -; Genomic_DNA.
DR EMBL; AY318571; AAP71746.1; -; Genomic_DNA.
DR EMBL; AL589651; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; U28779; AAC52402.1; -; Genomic_DNA.
DR CCDS; CCDS26283.1; -.
DR RefSeq; NP_666753.2; NM_146542.2.
DR AlphaFoldDB; Q60890; -.
DR SMR; Q60890; -.
DR STRING; 10090.ENSMUSP00000043099; -.
DR GlyGen; Q60890; 1 site.
DR PhosphoSitePlus; Q60890; -.
DR PaxDb; Q60890; -.
DR PRIDE; Q60890; -.
DR Antibodypedia; 67797; 64 antibodies from 17 providers.
DR DNASU; 218066; -.
DR Ensembl; ENSMUST00000043081; ENSMUSP00000043099; ENSMUSG00000036658.
DR Ensembl; ENSMUST00000205631; ENSMUSP00000146091; ENSMUSG00000036658.
DR GeneID; 218066; -.
DR KEGG; mmu:218066; -.
DR UCSC; uc007pqw.1; mouse.
DR CTD; 218066; -.
DR MGI; MGI:104715; Olfr11.
DR VEuPathDB; HostDB:ENSMUSG00000036658; -.
DR eggNOG; ENOG502SI2C; Eukaryota.
DR GeneTree; ENSGT01050000244863; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q60890; -.
DR OMA; QMLVNLC; -.
DR OrthoDB; 933513at2759; -.
DR PhylomeDB; Q60890; -.
DR TreeFam; TF336512; -.
DR BioGRID-ORCS; 218066; 0 hits in 68 CRISPR screens.
DR ChiTaRS; Olfr11; mouse.
DR PRO; PR:Q60890; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q60890; protein.
DR Bgee; ENSMUSG00000036658; Expressed in white adipose tissue.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..313
FT /note="Olfactory receptor 11"
FT /id="PRO_0000150810"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..143
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..200
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 222..244
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..313
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 260
FT /note="F -> L (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 313 AA; 35459 MW; 14A9460FC8B00B9C CRC64;
MSWANESITG EFVLLGFSDQ PWLEFPLFVV FLTSYIVTIF GNLNIILVSH LDPKLHTPMY
FFLTNLSVID LCYITCTVPQ MLVNLRSIRK VISFGGCVVQ LFMFLALGAT ECVLLPVMSF
DRFVAICRPL HYSVIMHQRL CLQLAAVSWI IGFGNSVWLS ILTLQLPRCG HYVIDHFLCE
VPALLKLSCV DVTANEAELF FVSVFFHLTP LSLILTSYAF IARAILKIQS AEGRQKAFGT
CSSHLIVVSL FYGTALSVYF LPPSPHSKNR RKMVPLFYGI IAPMLNPLIY TLRNKEVKDA
FKRLIKRVFL SKN
