OLF12_MOUSE
ID OLF12_MOUSE Reviewed; 333 AA.
AC Q60894; Q7TQS5;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Olfactory receptor 12;
DE AltName: Full=Odorant receptor M76;
GN Name=Olfr12;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14611657; DOI=10.1186/gb-2003-4-11-r71;
RA Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A.,
RA Walker M., Williams E.M., Trask B.J.;
RT "Odorant receptor expressed sequence tags demonstrate olfactory expression
RT of over 400 genes, extensive alternate splicing and unequal expression
RT levels.";
RL Genome Biol. 4:R71.1-R71.13(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 135-246.
RC STRAIN=C57BL/6J;
RX PubMed=8570653; DOI=10.1073/pnas.93.2.884;
RA Sullivan S.L., Adamson M.C., Ressler K.J., Kozak C.A., Buck L.B.;
RT "The chromosomal distribution of mouse odorant receptor genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:884-888(1996).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY318626; AAP71786.1; -; Genomic_DNA.
DR EMBL; U28783; AAC52406.1; -; Genomic_DNA.
DR CCDS; CCDS15174.1; -.
DR RefSeq; NP_996779.1; NM_206896.2.
DR AlphaFoldDB; Q60894; -.
DR SMR; Q60894; -.
DR STRING; 10090.ENSMUSP00000080027; -.
DR GlyGen; Q60894; 1 site.
DR PaxDb; Q60894; -.
DR PRIDE; Q60894; -.
DR Ensembl; ENSMUST00000081274; ENSMUSP00000080027; ENSMUSG00000061616.
DR Ensembl; ENSMUST00000213247; ENSMUSP00000150858; ENSMUSG00000061616.
DR GeneID; 257890; -.
DR KEGG; mmu:257890; -.
DR UCSC; uc007cbp.2; mouse.
DR CTD; 257890; -.
DR MGI; MGI:107863; Olfr12.
DR VEuPathDB; HostDB:ENSMUSG00000061616; -.
DR eggNOG; ENOG502SKXC; Eukaryota.
DR GeneTree; ENSGT01050000244934; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q60894; -.
DR OMA; TMRPSVC; -.
DR OrthoDB; 968478at2759; -.
DR PhylomeDB; Q60894; -.
DR TreeFam; TF352758; -.
DR BioGRID-ORCS; 257890; 2 hits in 63 CRISPR screens.
DR PRO; PR:Q60894; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q60894; protein.
DR ExpressionAtlas; Q60894; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..333
FT /note="Olfactory receptor 12"
FT /id="PRO_0000150811"
FT TOPO_DOM 1..35
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 57..72
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..106
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 128..150
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 172..203
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..251
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..272
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 273..278
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 300..333
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 104..196
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 241
FT /note="R -> G (in Ref. 2; AAC52406)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 333 AA; 36180 MW; AB64889218F84127 CRC64;
MATAVHRNGS LTPVSLRVFV LVGFGGGALT QALLFAVFLV LYVVTVLGNL TMIVVITLDA
RLHSPMYFFL KNLSFVDLCY SSAIAPNALA NFLSTSKVIS FEACATQFFF FSLLATTETF
LLAVMAYDRF MAICSPLRYP VTMCPTTCTR LVLGTFCVGC LNSIVQTSLT FQLPFCSSNR
IDHFYCDVPP LLQLACASTA LNELFLFGLC GFIIVSTTLA VLVSYGYITV TILRMHSGSG
RHKVFSTCGS HLTAVSLFYG TLFVMYAQPG ALTSMEQGKV VSIFYTLVIP MLNPLIYSLR
NKDVKDALQR LGQRHSLVKA VRGCPAAGGN ASV
