OLF13_MOUSE
ID OLF13_MOUSE Reviewed; 310 AA.
AC P34984; Q8VFS2;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Olfactory receptor 13;
DE AltName: Full=Odorant receptor K7;
DE AltName: Full=Olfactory receptor 261-6;
GN Name=Olfr13; Synonyms=Mor261-6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [3]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 60-281.
RC STRAIN=C57BL/6J; TISSUE=Liver;
RX PubMed=7683976; DOI=10.1016/0092-8674(93)90145-g;
RA Ressler K.J., Sullivan S.L., Buck L.B.;
RT "A zonal organization of odorant receptor gene expression in the olfactory
RT epithelium.";
RL Cell 73:597-609(1993).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Olfactory epithelium.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY073444; AAL61107.1; -; Genomic_DNA.
DR EMBL; AY317543; AAP70951.1; -; Genomic_DNA.
DR EMBL; L14566; AAA39850.1; -; Genomic_DNA.
DR CCDS; CCDS20089.1; -.
DR PIR; D40745; D40745.
DR RefSeq; NP_666863.1; NM_146652.1.
DR AlphaFoldDB; P34984; -.
DR SMR; P34984; -.
DR STRING; 10090.ENSMUSP00000053813; -.
DR GlyGen; P34984; 2 sites.
DR iPTMnet; P34984; -.
DR PhosphoSitePlus; P34984; -.
DR PaxDb; P34984; -.
DR PRIDE; P34984; -.
DR Ensembl; ENSMUST00000059512; ENSMUSP00000053813; ENSMUSG00000043605.
DR Ensembl; ENSMUST00000216179; ENSMUSP00000149893; ENSMUSG00000043605.
DR GeneID; 18310; -.
DR KEGG; mmu:18310; -.
DR UCSC; uc009bsi.1; mouse.
DR CTD; 18310; -.
DR MGI; MGI:104812; Olfr13.
DR VEuPathDB; HostDB:ENSMUSG00000043605; -.
DR eggNOG; ENOG502SM15; Eukaryota.
DR GeneTree; ENSGT00940000161677; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; P34984; -.
DR OMA; VISYMCI; -.
DR OrthoDB; 1051895at2759; -.
DR PhylomeDB; P34984; -.
DR TreeFam; TF337251; -.
DR BioGRID-ORCS; 18310; 3 hits in 66 CRISPR screens.
DR PRO; PR:P34984; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; P34984; protein.
DR Bgee; ENSMUSG00000043605; Expressed in testis and 1 other tissue.
DR ExpressionAtlas; P34984; baseline and differential.
DR GO; GO:0032154; C:cleavage furrow; ISO:MGI.
DR GO; GO:0090543; C:Flemming body; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; ISO:MGI.
DR GO; GO:1990023; C:mitotic spindle midzone; ISO:MGI.
DR GO; GO:0097431; C:mitotic spindle pole; ISO:MGI.
DR GO; GO:0055037; C:recycling endosome; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; ISO:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISO:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISO:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Olfactory receptor 13"
FT /id="PRO_0000150812"
FT TOPO_DOM 1..24
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 46..53
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..74
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 75..96
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 118..148
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 170..204
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..273
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 194
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 96..178
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 310 AA; 34569 MW; D890E00C89F0521F CRC64;
MGNNMTLITE FILLGFPLSP RMQMLLFALF SLFYAFTLLG NGTIVGLICL DSRLHTPMYF
FLSHLAIVDI AYACNTVPQM LVNLLDPVKP ISYAGCMTQT FLFLTFAITE CLLLVVMSYD
RYVAICHPLR YSAIMSWRVC STMAVTSWII GVLLSLIHLV LLLPLPFCVS QKVNHFFCEI
TAILKLACAD THLNETMVLA GAVSVLVGPF SSIVVSYACI LGAILKIQSE EGQRKAFSTC
SSHLCVVGLF YGTAIVMYVG PRHGSPKEQK KYLLLFHSLF NPMLNPLIYS LRNSDVKNTL
KRVLRTQRAL
