OLF18_MOUSE
ID OLF18_MOUSE Reviewed; 331 AA.
AC Q0VAX9; Q62337; Q7TRE8; Q8VFJ2;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Olfactory receptor 18;
DE AltName: Full=Olfactory receptor 145-1;
DE AltName: Full=Olfactory receptor TPCR34;
GN Name=Olfr18; Synonyms=Mor145-1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-331.
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [3]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-331.
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 148-304.
RC TISSUE=Testis;
RX PubMed=9119360; DOI=10.1006/geno.1996.4490;
RA Vanderhaeghen P., Schurmans S., Vassart G., Parmentier M.;
RT "Specific repertoire of olfactory receptor genes in the male germ cells of
RT several mammalian species.";
RL Genomics 39:239-246(1997).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC120866; AAI20867.2; -; mRNA.
DR EMBL; BC120868; AAI20869.2; -; mRNA.
DR EMBL; AY318053; AAP71350.1; -; Genomic_DNA.
DR EMBL; AY073534; AAL61197.1; -; Genomic_DNA.
DR EMBL; X89686; CAA61833.1; -; mRNA.
DR CCDS; CCDS40542.1; -.
DR PIR; S58067; S58067.
DR RefSeq; NP_666774.1; NM_146563.1.
DR AlphaFoldDB; Q0VAX9; -.
DR SMR; Q0VAX9; -.
DR STRING; 10090.ENSMUSP00000083664; -.
DR GlyGen; Q0VAX9; 1 site.
DR PhosphoSitePlus; Q0VAX9; -.
DR PaxDb; Q0VAX9; -.
DR PRIDE; Q0VAX9; -.
DR Ensembl; ENSMUST00000086473; ENSMUSP00000083664; ENSMUSG00000066896.
DR GeneID; 18315; -.
DR KEGG; mmu:18315; -.
DR UCSC; uc009oii.1; mouse.
DR CTD; 18315; -.
DR MGI; MGI:109317; Olfr18.
DR VEuPathDB; HostDB:ENSMUSG00000066896; -.
DR eggNOG; ENOG502T9MT; Eukaryota.
DR GeneTree; ENSGT00940000153277; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q0VAX9; -.
DR OMA; LFACMES; -.
DR OrthoDB; 1088794at2759; -.
DR PhylomeDB; Q0VAX9; -.
DR TreeFam; TF337210; -.
DR BioGRID-ORCS; 18315; 0 hits in 66 CRISPR screens.
DR PRO; PR:Q0VAX9; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q0VAX9; protein.
DR ExpressionAtlas; Q0VAX9; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..331
FT /note="Olfactory receptor 18"
FT /id="PRO_0000269660"
FT TOPO_DOM 1..47
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..68
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 69..80
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..100
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 101..119
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 141..164
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 186..218
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 219..239
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 240..266
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..287
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 288..293
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 315..331
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 27
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 119..201
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 226
FT /note="A -> T (in Ref. 5; CAA61833)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 331 AA; 37358 MW; 39F08F851DDECA43 CRC64;
MMDRYSFIMH QHRDDTVWCP SKIEEQNITR ISEFHLMGLS DDLQLQPILF GLFLSMYLVT
LLGNLLIILT VSSDSHLHSP MYFFLSNLSL ADVSFTSTTL PKMIVDIQTH NRAISYSGCL
TQMSFFMLFG CLDSLLLTAM AYDRFVAICH PLHYQFIMNP RLCGLLVFLS VLISLFVSQL
HNSVVLQLTY FKSVDISHFF CDPSQLLNLA CSDTFTNNIV MYFVGAISGF LPISGIFFSY
YKIVSSILRM PSPGGKYKAF STCGSHLSVV CLFYGTGLGV YLSSAVSLSP RKGAVASIVY
TVVTPMLNPF IYSLRNQDIK RAMWRLLRKT V
