OLF19_MOUSE
ID OLF19_MOUSE Reviewed; 309 AA.
AC Q9JHB2; Q9JM32;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Olfactory receptor 19;
DE AltName: Full=Odorant receptor M12;
DE AltName: Full=Olfactory receptor 140-1;
GN Name=Olfr19; Synonyms=Mor140-1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [3]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ;
RA Feinstein P., Mombaerts P.;
RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX PubMed=10706615; DOI=10.1073/pnas.040580197;
RA Rouquier S., Blancher A., Giorgi D.;
RT "The olfactory receptor gene repertoire in primates and mouse: evidence for
RT reduction of the functional fraction in primates.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:2870-2874(2000).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY073758; AAL61421.1; -; Genomic_DNA.
DR EMBL; AY317246; AAP70757.1; -; Genomic_DNA.
DR EMBL; AF283558; AAF91473.1; -; Genomic_DNA.
DR EMBL; AF073970; AAD43419.1; -; Genomic_DNA.
DR CCDS; CCDS27987.1; -.
DR RefSeq; NP_666447.1; NM_146335.1.
DR AlphaFoldDB; Q9JHB2; -.
DR SMR; Q9JHB2; -.
DR STRING; 10090.ENSMUSP00000053393; -.
DR GlyGen; Q9JHB2; 1 site.
DR PaxDb; Q9JHB2; -.
DR PRIDE; Q9JHB2; -.
DR DNASU; 18316; -.
DR Ensembl; ENSMUST00000057886; ENSMUSP00000053393; ENSMUSG00000048101.
DR Ensembl; ENSMUST00000206365; ENSMUSP00000145655; ENSMUSG00000048101.
DR GeneID; 18316; -.
DR KEGG; mmu:18316; -.
DR UCSC; uc007yiz.1; mouse.
DR CTD; 18316; -.
DR MGI; MGI:109316; Olfr19.
DR VEuPathDB; HostDB:ENSMUSG00000048101; -.
DR eggNOG; ENOG502RTYS; Eukaryota.
DR GeneTree; ENSGT00940000153523; -.
DR HOGENOM; CLU_012526_1_3_1; -.
DR InParanoid; Q9JHB2; -.
DR OMA; HFMCELY; -.
DR OrthoDB; 984499at2759; -.
DR PhylomeDB; Q9JHB2; -.
DR TreeFam; TF337210; -.
DR BioGRID-ORCS; 18316; 2 hits in 66 CRISPR screens.
DR PRO; PR:Q9JHB2; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q9JHB2; protein.
DR Bgee; ENSMUSG00000048101; Expressed in respiratory tract epithelium and 5 other tissues.
DR ExpressionAtlas; Q9JHB2; baseline and differential.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..309
FT /note="Olfactory receptor 19"
FT /id="PRO_0000150814"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..244
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..179
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 138
FT /note="C -> R (in Ref. 5; AAD43419)"
FT /evidence="ECO:0000305"
FT CONFLICT 238
FT /note="F -> S (in Ref. 5; AAD43419)"
FT /evidence="ECO:0000305"
FT CONFLICT 258
FT /note="V -> A (in Ref. 5; AAD43419)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 309 AA; 34661 MW; D29FBD5E084C2B95 CRC64;
MELKNDTQIS KFILLGISED PLWQPFLFGL FLFMYLVTLL GNLLIIIATI TDSHLHTPMY
FFLSNLSFAD ICFTSASIPK MLVNIQTKNK VITYEGCISQ VFFFILFGVL DNFLLAVMAY
DRYVAICHPL HYMVIMNCRL CGFLVLGSWV TTALNSLLQS SMALRLSFCT DLKIPHFVCE
LNQLVLLACN DTFPNDMVMY FAAILLGGGP LAGILYSYSK IVSSIRAISS SQGKYKAFST
CASHLSVVSL FYSTLLGVYL SSSFTQNSHS TARASVMYSV VTPMLNPFIY SLRNKDLMGA
LRRLLRRKS
