OLF1_MOUSE
ID OLF1_MOUSE Reviewed; 314 AA.
AC Q8VGI1;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Olfactory receptor 1;
DE AltName: Full=Odorant receptor I54;
DE AltName: Full=Olfactory receptor 135-13;
GN Name=Olfr1 {ECO:0000312|MGI:MGI:102698};
GN Synonyms=Mor135-13 {ECO:0000303|PubMed:11802173};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:AAL60830.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2] {ECO:0000312|EMBL:AAP70908.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14611657; DOI=10.1186/gb-2003-4-11-r71;
RA Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A.,
RA Walker M., Williams E.M., Trask B.J.;
RT "Odorant receptor expressed sequence tags demonstrate olfactory expression
RT of over 400 genes, extensive alternate splicing and unequal expression
RT levels.";
RL Genome Biol. 4:R71.1-R71.13(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4] {ECO:0000305, ECO:0000312|PIR:C54823}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-10, AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J {ECO:0000269|PubMed:8087849};
RC TISSUE=Nasal epithelium {ECO:0000269|PubMed:8087849};
RX PubMed=8087849; DOI=10.1016/s0092-8674(94)90562-2;
RA Chess A., Simon I., Cedar H., Axel R.;
RT "Allelic inactivation regulates olfactory receptor gene expression.";
RL Cell 78:823-834(1994).
CC -!- FUNCTION: Odorant receptor. Activated by a lily-derived aldehyde as
CC well as other odorants. May signal through an inositol 1,4,5-
CC trisphosphate (IP3) second messenger system (By similarity).
CC {ECO:0000250|UniProtKB:P70526}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Olfactory epithelium. {ECO:0000269|PubMed:8087849}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY073167; AAL60830.1; -; Genomic_DNA.
DR EMBL; AY317476; AAP70908.1; -; Genomic_DNA.
DR EMBL; AL645739; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS25008.1; -.
DR PIR; C54823; C54823.
DR RefSeq; NP_667132.1; NM_146921.2.
DR AlphaFoldDB; Q8VGI1; -.
DR SMR; Q8VGI1; -.
DR STRING; 10090.ENSMUSP00000113707; -.
DR GlyGen; Q8VGI1; 3 sites.
DR PaxDb; Q8VGI1; -.
DR PRIDE; Q8VGI1; -.
DR DNASU; 258923; -.
DR Ensembl; ENSMUST00000120303; ENSMUSP00000113707; ENSMUSG00000069823.
DR GeneID; 258923; -.
DR KEGG; mmu:258923; -.
DR UCSC; uc007kap.2; mouse.
DR CTD; 258923; -.
DR MGI; MGI:102698; Olfr1.
DR VEuPathDB; HostDB:ENSMUSG00000069823; -.
DR eggNOG; ENOG502SI5J; Eukaryota.
DR GeneTree; ENSGT00940000153124; -.
DR HOGENOM; CLU_012526_1_3_1; -.
DR InParanoid; Q8VGI1; -.
DR OMA; MFLIRVD; -.
DR OrthoDB; 924696at2759; -.
DR PhylomeDB; Q8VGI1; -.
DR TreeFam; TF337210; -.
DR BioGRID-ORCS; 258923; 3 hits in 64 CRISPR screens.
DR PRO; PR:Q8VGI1; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8VGI1; protein.
DR ExpressionAtlas; Q8VGI1; differential.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 1"
FT /id="PRO_0000233898"
FT TOPO_DOM 1..29
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..143
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 265
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 266
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..179
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 314 AA; 35479 MW; 0120E6CB7D229EE0 CRC64;
MTERNKTVIS QFLLLGLPIP PEHQQLFYAL FLVMYLTTVL GNLIIIILII LDSHLHTPMY
LFLSNLSFSD LCFSSVTMPK LLQNMQSQVP SIPYAGCLAQ IYFFLFFGDL GNFLLVAMAY
DRYVAICYPL HYTTIMSPRL CVSLVVLSWV LTTFHAMLHT LLMARLSFCE DNVIPHYFCD
MSALLKLACS DTRVNEVVIF IVASIFLVLP FALITMSYVR IVSSILKVPS SQGIYKAFST
CGSHLSVVSL FYGTVIGLYL SPSSNNSTVK DTVMSLMYTV VTPMLNPFIY SLRNRDIKGA
LERVFCKRKI QLNL
