OLF1_RAT
ID OLF1_RAT Reviewed; 314 AA.
AC P70526; Q04059; Q9QWW7;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Olfactory receptor 1;
DE AltName: Full=Olfactory receptor 1469;
DE AltName: Full=Olfactory receptor HGL-SP1;
DE AltName: Full=Olfactory receptor OR5;
DE AltName: Full=Olfactory receptor-like protein I54;
GN Name=Olfr1 {ECO:0000250|UniProtKB:Q8VGI1};
GN Synonyms=Olr1469 {ECO:0000312|RGD:1359186};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000305, ECO:0000312|EMBL:CAA68842.1, ECO:0000312|PIR:S29707}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Olfactory epithelium {ECO:0000312|EMBL:CAA68842.1};
RX PubMed=7678922; DOI=10.1038/361353a0;
RA Raming K., Krieger J., Strotmann J., Boekhoff I., Kubick S., Baumstark C.,
RA Breer H.;
RT "Cloning and expression of odorant receptors.";
RL Nature 361:353-356(1993).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAC64592.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 64-284.
RC STRAIN=Sprague-Dawley {ECO:0000269|PubMed:9858390};
RC TISSUE=Olfactory bulb {ECO:0000269|PubMed:9858390};
RX PubMed=9858390; DOI=10.1097/00001756-199811160-00032;
RA Singer M.S., Hughes T.E., Shepherd G.M., Greer C.A.;
RT "Identification of olfactory receptor mRNA sequences from the rat olfactory
RT bulb glomerular layer.";
RL NeuroReport 9:3745-3748(1998).
RN [3] {ECO:0000312|EMBL:AAA41738.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 193-236.
RC STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAA41738.1};
RC TISSUE=Olfactory epithelium {ECO:0000312|EMBL:AAA41738.1};
RX PubMed=1840504; DOI=10.1016/0092-8674(91)90418-x;
RA Buck L., Axel R.;
RT "A novel multigene family may encode odorant receptors: a molecular basis
RT for odor recognition.";
RL Cell 65:175-187(1991).
RN [4] {ECO:0000305}
RP FUNCTION.
RX PubMed=2164471; DOI=10.1002/j.1460-2075.1990.tb07422.x;
RA Boekhoff I., Tareilus E., Strotmann J., Breer H.;
RT "Rapid activation of alternative second messenger pathways in olfactory
RT cilia from rats by different odorants.";
RL EMBO J. 9:2453-2458(1990).
CC -!- FUNCTION: Odorant receptor. Activated by a lily-derived aldehyde as
CC well as other odorants. May signal through an inositol 1,4,5-
CC trisphosphate (IP3) second messenger system.
CC {ECO:0000269|PubMed:2164471, ECO:0000269|PubMed:7678922}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Olfactory epithelium. {ECO:0000269|PubMed:7678922}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; Y07557; CAA68842.1; -; mRNA.
DR EMBL; AF091571; AAC64592.1; -; mRNA.
DR EMBL; M64375; AAA41738.1; -; mRNA.
DR PIR; S29707; S29707.
DR RefSeq; NP_997692.1; NM_212527.1.
DR RefSeq; XP_003750900.1; XM_003750852.1.
DR RefSeq; XP_008766355.1; XM_008768133.1.
DR AlphaFoldDB; P70526; -.
DR SMR; P70526; -.
DR STRING; 10116.ENSRNOP00000066076; -.
DR GlyGen; P70526; 3 sites.
DR PaxDb; P70526; -.
DR PRIDE; P70526; -.
DR Ensembl; ENSRNOT00000102523; ENSRNOP00000080919; ENSRNOG00000067008.
DR Ensembl; ENSRNOT00000120256; ENSRNOP00000094670; ENSRNOG00000067008.
DR GeneID; 404976; -.
DR KEGG; rno:404976; -.
DR CTD; 404976; -.
DR RGD; 1359186; Olr1469.
DR VEuPathDB; HostDB:ENSRNOG00000065934; -.
DR eggNOG; ENOG502SI5J; Eukaryota.
DR GeneTree; ENSGT00940000153124; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; P70526; -.
DR OMA; MFLIRVD; -.
DR OrthoDB; 924696at2759; -.
DR PhylomeDB; P70526; -.
DR TreeFam; TF337210; -.
DR PRO; PR:P70526; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Genevisible; P70526; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 1"
FT /id="PRO_0000233899"
FT TOPO_DOM 1..29
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..59
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..81
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 82..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..143
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 265
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 266
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..179
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 181
FT /note="M -> T (in Ref. 2; AAC64592)"
FT /evidence="ECO:0000305"
FT CONFLICT 236
FT /note="K -> E (in Ref. 2; AAC64592)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 314 AA; 35537 MW; CFA3F5BF0BD1F896 CRC64;
MTERNQTVIS QFLLLGLPIP PEHQHVFYAL FLSMYLTTVL GNLIIIILIL LDSHLHTPMY
LFLSNLSFSD LCFSSVTMPK LLQNMQSQVP SIPYAGCLSQ IYFFLFFGDL GNFLLVAMAY
DRYVAICFPL HYMSIMSPKL CVSLVVLSWV LTTFHAMLHT LLMARLSFCE DNVIPHFFCD
MSALLKLACS DTRVNEVVIF IVVSLFLVLP FALIIMSYVR IVSSILKVPS SQGIYKAFST
CGSHLSVVSL FYGTVIGLYL CPSSNNSTVK ETVMSLMYTV VTPMLNPFIY SLRNRDIKGA
MERIFCKRKI QLNL
