OLF24_MOUSE
ID OLF24_MOUSE Reviewed; 313 AA.
AC Q8VFM9; Q62340;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Olfactory receptor 24;
DE AltName: Full=Olfactory receptor 132-1;
DE AltName: Full=Olfactory receptor TPCR51;
GN Name=Olfr24; Synonyms=Mor132-1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [2]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14611657; DOI=10.1186/gb-2003-4-11-r71;
RA Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A.,
RA Walker M., Williams E.M., Trask B.J.;
RT "Odorant receptor expressed sequence tags demonstrate olfactory expression
RT of over 400 genes, extensive alternate splicing and unequal expression
RT levels.";
RL Genome Biol. 4:R71.1-R71.13(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 126-282, AND TISSUE SPECIFICITY.
RC TISSUE=Testis;
RX PubMed=9119360; DOI=10.1006/geno.1996.4490;
RA Vanderhaeghen P., Schurmans S., Vassart G., Parmentier M.;
RT "Specific repertoire of olfactory receptor genes in the male germ cells of
RT several mammalian species.";
RL Genomics 39:239-246(1997).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in testis. {ECO:0000269|PubMed:9119360}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY073491; AAL61154.1; -; Genomic_DNA.
DR EMBL; AY318003; AAP71315.1; -; Genomic_DNA.
DR EMBL; CH466522; EDL25055.1; -; Genomic_DNA.
DR EMBL; BC125621; AAI25622.1; -; mRNA.
DR EMBL; BC137822; AAI37823.1; -; mRNA.
DR EMBL; X89689; CAA61836.1; -; mRNA.
DR CCDS; CCDS22846.1; -.
DR PIR; S58032; S58032.
DR RefSeq; NP_666817.1; NM_146606.1.
DR AlphaFoldDB; Q8VFM9; -.
DR SMR; Q8VFM9; -.
DR STRING; 10090.ENSMUSP00000064189; -.
DR GlyGen; Q8VFM9; 2 sites.
DR PaxDb; Q8VFM9; -.
DR PRIDE; Q8VFM9; -.
DR Antibodypedia; 24990; 69 antibodies from 18 providers.
DR DNASU; 18322; -.
DR Ensembl; ENSMUST00000066997; ENSMUSP00000064189; ENSMUSG00000054141.
DR Ensembl; ENSMUST00000216754; ENSMUSP00000149702; ENSMUSG00000054141.
DR GeneID; 18322; -.
DR KEGG; mmu:18322; -.
DR UCSC; uc009ogw.1; mouse.
DR CTD; 18322; -.
DR MGI; MGI:109311; Olfr24.
DR VEuPathDB; HostDB:ENSMUSG00000054141; -.
DR eggNOG; ENOG502T9JZ; Eukaryota.
DR GeneTree; ENSGT00940000163044; -.
DR HOGENOM; CLU_012526_1_3_1; -.
DR InParanoid; Q8VFM9; -.
DR OMA; FCGNNEL; -.
DR OrthoDB; 875656at2759; -.
DR PhylomeDB; Q8VFM9; -.
DR TreeFam; TF337210; -.
DR BioGRID-ORCS; 18322; 1 hit in 66 CRISPR screens.
DR PRO; PR:Q8VFM9; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q8VFM9; protein.
DR Bgee; ENSMUSG00000054141; Expressed in respiratory tract epithelium and 2 other tissues.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..313
FT /note="Olfactory receptor 24"
FT /id="PRO_0000352790"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..142
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..244
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..274
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..313
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 89
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..179
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 313 AA; 34863 MW; F65A9E002E69C7F8 CRC64;
MEPQNHTSAS EFILLGLSEK PDHDPVLFSL FLCMYMITVV GNLLIILAIS FDSHLHTPMY
FFLANLSLVD FCLATNTVPK MLVNIQTRNK SISYPCCLTQ MYFFHFFGIM DSVLIAVMAY
DRFVAICHPL HYSTIMSPRL CGLLVGVPWV YSCFISLTHI LLMARLVFCG KNELPHYFCD
LTPLLRLSCT DTTVNKIFVL IVAGMVIATP FVCILASYAR IIVAIMKVPS AGGRKKAFST
CSSHLSVVAL FYGTTIGVYL CPSSVRTAVK EKASAVMYTA VTPMLNPFIY SLRNRDLKGA
LKKIINRKIS TSS
