ID   ARTA_ASPFN              Reviewed;         238 AA.
AC   B8NLM9;
DT   25-APR-2018, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=14-3-3 family protein artA {ECO:0000303|PubMed:29247055};
GN   Name=artA {ECO:0000303|PubMed:29247055}; ORFNames=AFLA_092450;
OS   Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357
OS   / JCM 12722 / SRRC 167).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=332952;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC
RC   167;
RX   PubMed=25883274; DOI=10.1128/genomea.00168-15;
RA   Nierman W.C., Yu J., Fedorova-Abrams N.D., Losada L., Cleveland T.E.,
RA   Bhatnagar D., Bennett J.W., Dean R., Payne G.A.;
RT   "Genome sequence of Aspergillus flavus NRRL 3357, a strain that causes
RT   aflatoxin contamination of food and feed.";
RL   Genome Announc. 3:E0016815-E0016815(2015).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=29247055; DOI=10.1128/aem.02241-17;
RA   Ibarra B.A., Lohmar J.M., Satterlee T., McDonald T., Cary J.W., Calvo A.M.;
RT   "The 14-3-3 protein homolog ArtA regulates development and secondary
RT   metabolism in the opportunistic plant pathogen Aspergillus flavus.";
RL   Appl. Environ. Microbiol. 84:0-0(2018).
CC   -!- FUNCTION: 14-3-3 family protein that plays a role in the morphological
CC       differentiation and secondary metabolism biosynthesis
CC       (PubMed:29247055). Required for normal fungal morphogenesis in an
CC       environment-dependent manner, affecting the balance between production
CC       of conidiophores and the formation of sclerotia, resistant structures
CC       that are necessary for the dissemination and survival
CC       (PubMed:29247055). Acts as a positive regulator of conidiation and a
CC       negative regulator of sclerotial production (PubMed:29247055).
CC       Regulates also the production of secondary metabolites such as
CC       aflatoxin, but also the indole-tetramic acid mycotoxin cyclopiazonic
CC       acid (CPA) and ustiloxin, an inhibitor of microtubule assembly
CC       (PubMed:29247055). {ECO:0000269|PubMed:29247055}.
CC   -!- DISRUPTION PHENOTYPE: Diminishes colony growth and affects conidiation
CC       (PubMed:29247055). Decrease in the expression of transcription factors
CC       brlA and wetA, components of the central regulatory pathway essential
CC       for conidiophore formation (PubMed:29247055). Increases the expression
CC       of nsdC, encoding a transcription factor necessary for normal
CC       sclerotial production, ans subsequent production of sclerotia
CC       (PubMed:29247055). Increases also the production of aflatoxinvia the
CC       induction of aflatoxin cluster regulatory genes aflR, aflJ and ver1
CC       (PubMed:29247055). Dicreases the expression of the polyketide synthase-
CC       nonribosomal peptide synthetase (PKS/NRPS) gene (AFLA_139490),
CC       essential in the synthesis of cyclopiazonic acid (CPA), and of ustD,
CC       involved in the production of ustiloxin (PubMed:29247055).
CC       {ECO:0000269|PubMed:29247055}.
CC   -!- SIMILARITY: Belongs to the 14-3-3 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; EQ963480; EED49164.1; -; Genomic_DNA.
DR   RefSeq; XP_002381065.1; XM_002381024.1.
DR   AlphaFoldDB; B8NLM9; -.
DR   SMR; B8NLM9; -.
DR   STRING; 5059.CADAFLAP00008930; -.
DR   EnsemblFungi; EED49164; EED49164; AFLA_092450.
DR   VEuPathDB; FungiDB:AFLA_092450; -.
DR   eggNOG; KOG0841; Eukaryota.
DR   HOGENOM; CLU_058290_0_0_1; -.
DR   OMA; IPCATTG; -.
DR   Proteomes; UP000001875; Unassembled WGS sequence.
DR   Gene3D; 1.20.190.20; -; 1.
DR   InterPro; IPR000308; 14-3-3.
DR   InterPro; IPR023409; 14-3-3_CS.
DR   InterPro; IPR036815; 14-3-3_dom_sf.
DR   InterPro; IPR023410; 14-3-3_domain.
DR   PANTHER; PTHR18860; PTHR18860; 1.
DR   Pfam; PF00244; 14-3-3; 1.
DR   PIRSF; PIRSF000868; 14-3-3; 1.
DR   PRINTS; PR00305; 1433ZETA.
DR   SMART; SM00101; 14_3_3; 1.
DR   SUPFAM; SSF48445; SSF48445; 1.
DR   PROSITE; PS00796; 1433_1; 1.
DR   PROSITE; PS00797; 1433_2; 1.
PE   3: Inferred from homology;
FT   CHAIN           1..238
FT                   /note="14-3-3 family protein artA"
FT                   /id="PRO_0000443855"
SQ   SEQUENCE   238 AA;  26869 MW;  31ECEFA3EB45A72A CRC64;
     MGHEDAVYLA KLAEQAERYE EMVENMKVVA SADVELTVEE RNLLSVAYKN VIGARRASWR
     IVTSIEQKEE SKGNESQVTL IKEYRQKIES ELAKICDDIL EVLDKHLIPS AQSGESKVFY
     HKMKGDYHRY LAEFAIGDRR KGAADASLEA YKAATEVAQT DLAPTHPIRL GLALNFSVFY
     YEILNSPDQA CHLAKLAFDD AIAELDTLSE ESYKDSTLIM QLLRDNLTLW TSSEPSRC