ID   OLF3A_DANRE             Reviewed;         390 AA.
AC   Q29RB4; Q08BF8;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2009, sequence version 2.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Olfactomedin-like protein 3A;
DE   Flags: Precursor;
GN   Name=olfml3a; Synonyms=olfml3; ORFNames=zgc:153815;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Secreted scaffold protein that plays an essential role in
CC       dorsoventral patterning during early development. Stabilizes axial
CC       formation by restricting chordin (CHRD) activity on the dorsal side.
CC       Acts by facilitating the association between the tolloid proteases and
CC       their substrate chordin (CHRD), leading to enhance chordin (CHRD)
CC       degradation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OLFML3 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI14288.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC114287; AAI14288.1; ALT_INIT; mRNA.
DR   EMBL; BC124742; AAI24743.1; -; mRNA.
DR   RefSeq; NP_001070719.1; NM_001077251.1.
DR   AlphaFoldDB; Q29RB4; -.
DR   SMR; Q29RB4; -.
DR   STRING; 7955.ENSDARP00000084034; -.
DR   PaxDb; Q29RB4; -.
DR   Ensembl; ENSDART00000089601; ENSDARP00000084034; ENSDARG00000062171.
DR   GeneID; 562022; -.
DR   KEGG; dre:562022; -.
DR   CTD; 562022; -.
DR   ZFIN; ZDB-GENE-050302-161; olfml3b.
DR   eggNOG; KOG3545; Eukaryota.
DR   GeneTree; ENSGT00940000158083; -.
DR   HOGENOM; CLU_035236_2_1_1; -.
DR   InParanoid; Q29RB4; -.
DR   OMA; SQWHDQS; -.
DR   OrthoDB; 421994at2759; -.
DR   PhylomeDB; Q29RB4; -.
DR   TreeFam; TF352000; -.
DR   PRO; PR:Q29RB4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 11.
DR   Bgee; ENSDARG00000062171; Expressed in swim bladder and 21 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   InterPro; IPR003112; Olfac-like_dom.
DR   InterPro; IPR031230; OLFML3.
DR   PANTHER; PTHR23192:SF8; PTHR23192:SF8; 1.
DR   Pfam; PF02191; OLF; 1.
DR   SMART; SM00284; OLF; 1.
DR   PROSITE; PS51132; OLF; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Developmental protein; Disulfide bond; Glycoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..390
FT                   /note="Olfactomedin-like protein 3A"
FT                   /id="PRO_0000361563"
FT   DOMAIN          130..386
FT                   /note="Olfactomedin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00446"
FT   COILED          18..91
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        169
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        131..313
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00446"
SQ   SEQUENCE   390 AA;  44506 MW;  32AE7339C2B76151 CRC64;
     MRALQLLVLV LSGLVGAQQQ ALMDYLERRL LAIEDRISLW HEQTSRYASE LREFKQQMVA
     QLEGLDKSKE ALRSELDTVG TRVDRVEREM DYLETQNGAQ PCVDVDDKLV EQQVTFVKER
     NKAKYAKLTD CSDMISSIKA MKILKRVGGA KGMWTKDMGS ATGKVYILNG TDDNTVFEFG
     TVREFTSSQG TSGATTIQLP SAWRGMGHAI YNNHMYYLKQ GEEMKLIKFD LQKNIIVDSA
     VFPVKNQLPV YSLNPETFID LAVDEEGLWA IYATQENERH ISLAKIDPKT LDIQQMWDTP
     CVRENAEAAF VICGTVYVVY NSKLPSRSRI QCVFDVSDMV NNDEAPHVYF PKRYGTHSSL
     KYSPVEQLLY AWDDGYQILY KLQLKKKLEV