ID   OLF3B_DANRE             Reviewed;         394 AA.
AC   Q0P3W2;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Olfactomedin-like protein 3B;
DE   Flags: Precursor;
GN   Name=olfml3b; ORFNames=zgc:153761;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Olfactory epithelium;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Secreted scaffold protein that plays an essential role in
CC       dorsoventral patterning during early development. Stabilizes axial
CC       formation by restricting chordin (CHRD) activity on the dorsal side.
CC       Acts by facilitating the association between the tolloid proteases and
CC       their substrate chordin (CHRD), leading to enhance chordin (CHRD)
CC       degradation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OLFML3 family. {ECO:0000305}.
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DR   EMBL; BC122413; AAI22414.1; -; mRNA.
DR   RefSeq; NP_001039322.1; NM_001045857.1.
DR   AlphaFoldDB; Q0P3W2; -.
DR   SMR; Q0P3W2; -.
DR   STRING; 7955.ENSDARP00000083130; -.
DR   PaxDb; Q0P3W2; -.
DR   GeneID; 568106; -.
DR   KEGG; dre:568106; -.
DR   CTD; 568106; -.
DR   ZFIN; ZDB-GENE-060825-31; olfml3a.
DR   eggNOG; KOG3545; Eukaryota.
DR   InParanoid; Q0P3W2; -.
DR   OrthoDB; 421994at2759; -.
DR   PhylomeDB; Q0P3W2; -.
DR   PRO; PR:Q0P3W2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   InterPro; IPR003112; Olfac-like_dom.
DR   Pfam; PF02191; OLF; 1.
DR   SMART; SM00284; OLF; 1.
DR   PROSITE; PS51132; OLF; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Developmental protein; Disulfide bond; Glycoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..394
FT                   /note="Olfactomedin-like protein 3B"
FT                   /id="PRO_0000361564"
FT   DOMAIN          132..383
FT                   /note="Olfactomedin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00446"
FT   COILED          29..94
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        169
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        204
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        233
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        133..310
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00446"
SQ   SEQUENCE   394 AA;  44922 MW;  53D3A5CA1465E591 CRC64;
     MKATIFFLLL TVLAHSRSQY HYQGLMNYLE NRMLAMEERI ALWHEQNNRY NSDLKEFRQQ
     AADLLEKLSK DHSKLRSDLE GAGARVDRVE REMDYIETKN PPKPCVKAAD KMVEQDAVIK
     EKKKEEFFEL SVCVNIISSL KAMKILKRLG SPKGLWTKDA RSAKIYVFNG TSDNTLYEFS
     SMRELSSSSG VSKGKQITVP TAWNGTGHAV YDGFLYYISE SSELQVVKYD LTNSSVADTA
     VLPMEERSPV YQLNPETLVD LVADEDGLWA LYPAGDTINL AKMDSNSLDI EQMWDTACPR
     SNAEAAFIVC GTVYVVYNTK PPSRSRVQCV FDVNDMVSNG EAPLIYFPRR YGAHSSLKYN
     PEERQLYAWD DGYQILYKLE LKKKLWAVMP PPEE