OLF3_MOUSE
ID OLF3_MOUSE Reviewed; 313 AA.
AC Q60879; Q8VFP7;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Olfactory receptor 3;
DE AltName: Full=Odorant receptor K10;
DE AltName: Full=Olfactory receptor 136-14;
GN Name=Olfr3; Synonyms=Mor136-14;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14611657; DOI=10.1186/gb-2003-4-11-r71;
RA Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A.,
RA Walker M., Williams E.M., Trask B.J.;
RT "Odorant receptor expressed sequence tags demonstrate olfactory expression
RT of over 400 genes, extensive alternate splicing and unequal expression
RT levels.";
RL Genome Biol. 4:R71.1-R71.13(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 128-239.
RC STRAIN=C57BL/6J;
RX PubMed=8570653; DOI=10.1073/pnas.93.2.884;
RA Sullivan S.L., Adamson M.C., Ressler K.J., Kozak C.A., Buck L.B.;
RT "The chromosomal distribution of mouse odorant receptor genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:884-888(1996).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY073471; AAL61134.1; -; Genomic_DNA.
DR EMBL; AY317444; AAP70883.1; -; Genomic_DNA.
DR EMBL; U28768; AAC52391.1; -; Genomic_DNA.
DR CCDS; CCDS15982.1; -.
DR RefSeq; NP_996786.1; NM_206903.1.
DR AlphaFoldDB; Q60879; -.
DR SMR; Q60879; -.
DR STRING; 10090.ENSMUSP00000097728; -.
DR GlyGen; Q60879; 1 site.
DR iPTMnet; Q60879; -.
DR PhosphoSitePlus; Q60879; -.
DR PaxDb; Q60879; -.
DR PRIDE; Q60879; -.
DR Antibodypedia; 30306; 50 antibodies from 18 providers.
DR DNASU; 18328; -.
DR Ensembl; ENSMUST00000100151; ENSMUSP00000097728; ENSMUSG00000075384.
DR Ensembl; ENSMUST00000213988; ENSMUSP00000149118; ENSMUSG00000075384.
DR GeneID; 18328; -.
DR KEGG; mmu:18328; -.
DR UCSC; uc008jly.1; mouse.
DR CTD; 18328; -.
DR MGI; MGI:102697; Olfr3.
DR VEuPathDB; HostDB:ENSMUSG00000075384; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT00940000163027; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q60879; -.
DR OMA; WVIACAC; -.
DR OrthoDB; 1093328at2759; -.
DR PhylomeDB; Q60879; -.
DR TreeFam; TF337210; -.
DR BioGRID-ORCS; 18328; 3 hits in 66 CRISPR screens.
DR PRO; PR:Q60879; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q60879; protein.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..313
FT /note="Olfactory receptor 3"
FT /id="PRO_0000150804"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..142
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..313
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 313 AA; 34969 MW; 4A9EB8880E084FD0 CRC64;
MRLKNHSSVS EFLLLGFPIR PEQGGIFFSL FLAMYLITVL GNLLIILLIR LDSHLHTPMY
FFLSHLAFTD ISFSSVTVPK MLTKVQNQPI PITYEECVSQ TYFFIFFADL DSFLITSMAY
DRYMAICHPL HYITIMSQSR CAMLVAVSWV IASACALLHS LLLDQLSFCA DHTVPHFFCD
LGALLKLSCS DTSLNQLVIF TAGLAAIMLP FLCILISYGR IGFTILQVPT TKGICKALST
CGSHLSVVAL YYGSIIGLYF LPPSNSKINN NIVASVMYTV VTPMLNPFIY SLRNKDMKGA
LKKLLSKKTE FSK
