OLF49_MOUSE
ID OLF49_MOUSE Reviewed; 313 AA.
AC Q9Z1V0; Q8VFB7;
DT 01-MAY-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Olfactory receptor 49 {ECO:0000312|EMBL:EDL36361.1};
DE AltName: Full=Olfactory receptor 118-1;
DE AltName: Full=Olfactory receptor I-C6 {ECO:0000303|PubMed:9875846};
GN Name=Olfr49 {ECO:0000312|EMBL:AAP71780.1,
GN ECO:0000312|Ensembl:ENSMUSP00000054361, ECO:0000312|MGI:MGI:1333764};
GN Synonyms=Mor118-1 {ECO:0000312|EMBL:AAL61277.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAD13315.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=129/SvJ {ECO:0000312|EMBL:AAD13315.1};
RX PubMed=9875846; DOI=10.1016/s0092-8674(00)81716-x;
RA Krautwurst D., Yau K.W., Reed R.R.;
RT "Identification of ligands for olfactory receptors by functional expression
RT of a receptor library.";
RL Cell 95:917-926(1998).
RN [2] {ECO:0000312|EMBL:AAL61277.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [3] {ECO:0000312|EMBL:AAP71780.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14611657; DOI=10.1186/gb-2003-4-11-r71;
RA Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A.,
RA Walker M., Williams E.M., Trask B.J.;
RT "Odorant receptor expressed sequence tags demonstrate olfactory expression
RT of over 400 genes, extensive alternate splicing and unequal expression
RT levels.";
RL Genome Biol. 4:R71.1-R71.13(2003).
RN [4] {ECO:0000312|Ensembl:ENSMUSP00000054361}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|Ensembl:ENSMUSP00000054361};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [5] {ECO:0000312|EMBL:EDL36361.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000312|EMBL:AAI45892.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Odorant receptor. Activated by (-)-citronellal and to a
CC lesser extent by (+)-citronellal. Not activated by carvone or limonene.
CC {ECO:0000269|PubMed:9875846}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255, ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF102523; AAD13315.1; -; Genomic_DNA.
DR EMBL; AY073614; AAL61277.1; -; Genomic_DNA.
DR EMBL; AY318614; AAP71780.1; -; Genomic_DNA.
DR EMBL; CT573018; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466535; EDL36361.1; -; Genomic_DNA.
DR EMBL; BC145891; AAI45892.1; -; mRNA.
DR EMBL; BC145893; AAI45894.1; -; mRNA.
DR CCDS; CCDS27085.1; -.
DR RefSeq; NP_035121.1; NM_010991.2.
DR AlphaFoldDB; Q9Z1V0; -.
DR SMR; Q9Z1V0; -.
DR STRING; 10090.ENSMUSP00000054361; -.
DR GlyGen; Q9Z1V0; 1 site.
DR PaxDb; Q9Z1V0; -.
DR PRIDE; Q9Z1V0; -.
DR Ensembl; ENSMUST00000059996; ENSMUSP00000054361; ENSMUSG00000048153.
DR Ensembl; ENSMUST00000216214; ENSMUSP00000149840; ENSMUSG00000048153.
DR GeneID; 18348; -.
DR KEGG; mmu:18348; -.
DR UCSC; uc007tvs.2; mouse.
DR CTD; 18348; -.
DR MGI; MGI:1333764; Olfr49.
DR VEuPathDB; HostDB:ENSMUSG00000048153; -.
DR eggNOG; ENOG502RDVH; Eukaryota.
DR GeneTree; ENSGT00960000186600; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q9Z1V0; -.
DR OMA; IVMYIRS; -.
DR OrthoDB; 1171161at2759; -.
DR PhylomeDB; Q9Z1V0; -.
DR TreeFam; TF336833; -.
DR BioGRID-ORCS; 18348; 3 hits in 66 CRISPR screens.
DR PRO; PR:Q9Z1V0; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q9Z1V0; protein.
DR Bgee; ENSMUSG00000048153; Expressed in dorsal root ganglion and 5 other tissues.
DR Genevisible; Q9Z1V0; MM.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0019840; F:isoprenoid binding; IDA:MGI.
DR GO; GO:0004984; F:olfactory receptor activity; IDA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..313
FT /note="Olfactory receptor 49"
FT /id="PRO_0000422153"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..177
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 49
FT /note="V -> A (in Ref. 2; AAL61277, 3; AAP71780 and 5;
FT EDL36361)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 313 AA; 35689 MW; 4457CEDF63458615 CRC64;
MANSTTVTEF ILLGLSDACE LQVLIFLGFL LTYFLILLGN FLIIFITLVD RRLYTPMYYF
LRNFAMLEIW FTSVIFPKML TNIITGHKTI SLLGCFLQAF LYFFLGTTEF FLLAVMSFDR
YVAICNPLRY ATIMSKRVCV QLVFCSWMSG LLLIIVPSSI VFQQPFCGPN IINHFFCDNF
PLMELICADT SLVEFLGFVI ANFSLLGTLA VTATCYGHIL YTILHIPSAK ERKKAFSTCS
SHIIVVSLFY GSCIFMYVRS GKNGQGEDHN KVVALLNTVV TPTLNPFIYT LRNKQVKQVF
REHVSKFQKF SQT
