OLF50_MOUSE
ID OLF50_MOUSE Reviewed; 312 AA.
AC Q8VGK5; Q9Z1U9;
DT 01-MAY-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Olfactory receptor 50 {ECO:0000312|EMBL:AAI27979.1};
DE AltName: Full=Olfactory receptor 136-6;
DE AltName: Full=Olfactory receptor I-D3 {ECO:0000303|PubMed:9875846};
GN Name=Olfr50 {ECO:0000312|EMBL:AAP70882.1, ECO:0000312|MGI:MGI:1333746};
GN Synonyms=Mor136-6 {ECO:0000312|EMBL:AAL60805.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:AAL60805.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2] {ECO:0000312|EMBL:AAP70882.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14611657; DOI=10.1186/gb-2003-4-11-r71;
RA Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A.,
RA Walker M., Williams E.M., Trask B.J.;
RT "Odorant receptor expressed sequence tags demonstrate olfactory expression
RT of over 400 genes, extensive alternate splicing and unequal expression
RT levels.";
RL Genome Biol. 4:R71.1-R71.13(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4] {ECO:0000312|EMBL:EDL08685.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000312|EMBL:AAI27979.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6] {ECO:0000305, ECO:0000312|EMBL:AAD13316.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 64-286, AND FUNCTION.
RC STRAIN=C57BL/6J {ECO:0000269|PubMed:9875846};
RC TISSUE=Olfactory epithelium {ECO:0000312|EMBL:AAD13316.1};
RX PubMed=9875846; DOI=10.1016/s0092-8674(00)81716-x;
RA Krautwurst D., Yau K.W., Reed R.R.;
RT "Identification of ligands for olfactory receptors by functional expression
RT of a receptor library.";
RL Cell 95:917-926(1998).
CC -!- FUNCTION: Odorant receptor. Activated by (+) and (-)-carvone.
CC {ECO:0000269|PubMed:9875846}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255, ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY073142; AAL60805.1; -; Genomic_DNA.
DR EMBL; AY317443; AAP70882.1; -; Genomic_DNA.
DR EMBL; AL732452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466542; EDL08685.1; -; Genomic_DNA.
DR EMBL; BC127978; AAI27979.1; -; mRNA.
DR EMBL; AF102524; AAD13316.1; -; mRNA.
DR CCDS; CCDS15981.1; -.
DR RefSeq; NP_667157.1; NM_146946.1.
DR AlphaFoldDB; Q8VGK5; -.
DR SMR; Q8VGK5; -.
DR PaxDb; Q8VGK5; -.
DR PRIDE; Q8VGK5; -.
DR DNASU; 18350; -.
DR Ensembl; ENSMUST00000112950; ENSMUSP00000108572; ENSMUSG00000111021.
DR Ensembl; ENSMUST00000216753; ENSMUSP00000149648; ENSMUSG00000111021.
DR Ensembl; ENSMUST00000217041; ENSMUSP00000149484; ENSMUSG00000111021.
DR GeneID; 18350; -.
DR KEGG; mmu:18350; -.
DR UCSC; uc008jlx.1; mouse.
DR CTD; 18350; -.
DR MGI; MGI:1333746; Olfr50.
DR VEuPathDB; HostDB:ENSMUSG00000111021; -.
DR GeneTree; ENSGT00940000154381; -.
DR HOGENOM; CLU_012526_1_3_1; -.
DR InParanoid; Q8VGK5; -.
DR OMA; VIMSWAL; -.
DR OrthoDB; 1126809at2759; -.
DR PhylomeDB; Q8VGK5; -.
DR BioGRID-ORCS; 18350; 1 hit in 65 CRISPR screens.
DR PRO; PR:Q8VGK5; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8VGK5; protein.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0019840; F:isoprenoid binding; IDA:MGI.
DR GO; GO:0004984; F:olfactory receptor activity; IDA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Membrane; Olfaction; Receptor;
KW Reference proteome; Sensory transduction; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 50"
FT /id="PRO_0000422154"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 221
FT /note="I -> M (in Ref. 6; AAD13316)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 312 AA; 34794 MW; D4D09910C159BA6D CRC64;
MMKSNQSTVS EFILLGLPIQ PEDQAVYFAL FLAMYLTTVL GNLLIILLIR LDSHLHTPMY
FFLSHLAFTD ISFSSVTAPK MLMNMLTHSQ SISHAGCVSQ IYFFLLFGCI DNFLLTSMAY
DRYVAICHPL HYTTIMSQSL CVLLVMVSWA FSSSNGLVHT LLFARLSLFR DNTVHHFFCD
LSALLKLSSS DTTINELVIL TLAVVVITVP FICILVSYGH IGATILRTPS IKGICKALST
CGSHLCVVSL YYGAIIGLYF FPSSNNTNDK DVIVAVLYTV VTPMLNPFIY SLRNRDINGA
LRKTLSRRLC SH
