OLF56_MOUSE
ID OLF56_MOUSE Reviewed; 315 AA.
AC Q8VGD6; Q8BKF2; Q9QUL1; Q9Z1U2;
DT 01-MAY-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Olfactory receptor 56;
DE AltName: Full=Olfactory receptor 276-1;
DE AltName: Full=Olfactory receptor F7 {ECO:0000312|EMBL:AAD13325.1};
DE AltName: Full=Olfactory receptor G3 {ECO:0000312|EMBL:AAD13327.1};
DE AltName: Full=Olfactory receptor I-G7 {ECO:0000303|PubMed:9875846};
GN Name=Olfr56 {ECO:0000312|EMBL:AAI41220.1,
GN ECO:0000312|Ensembl:ENSMUSP00000099846, ECO:0000312|MGI:MGI:1333785};
GN Synonyms=Mor276-1 {ECO:0000312|EMBL:AAL60877.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAL60877.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAP71778.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
RX PubMed=14611657; DOI=10.1186/gb-2003-4-11-r71;
RA Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A.,
RA Walker M., Williams E.M., Trask B.J.;
RT "Odorant receptor expressed sequence tags demonstrate olfactory expression
RT of over 400 genes, extensive alternate splicing and unequal expression
RT levels.";
RL Genome Biol. 4:R71.1-R71.13(2003).
RN [3] {ECO:0000305, ECO:0000312|EMBL:BAC35358.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAC35358.1};
RC TISSUE=Eye {ECO:0000312|EMBL:BAC35358.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4] {ECO:0000312|Ensembl:ENSMUSP00000099846}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|Ensembl:ENSMUSP00000099846};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [5] {ECO:0000312|EMBL:EDL33775.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000305, ECO:0000312|EMBL:AAI41220.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7] {ECO:0000305, ECO:0000312|EMBL:AAD13329.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 65-287, AND FUNCTION.
RC STRAIN=C57BL/6J {ECO:0000269|PubMed:9875846};
RC TISSUE=Olfactory epithelium {ECO:0000312|EMBL:AAD13329.1};
RX PubMed=9875846; DOI=10.1016/s0092-8674(00)81716-x;
RA Krautwurst D., Yau K.W., Reed R.R.;
RT "Identification of ligands for olfactory receptors by functional expression
RT of a receptor library.";
RL Cell 95:917-926(1998).
CC -!- FUNCTION: Odorant receptor. Activated by (+) and (-)-limonene.
CC {ECO:0000269|PubMed:9875846}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255, ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1 {ECO:0000269|PubMed:11802173, ECO:0000269|PubMed:14611657,
CC ECO:0000269|PubMed:15489334};
CC IsoId=Q8VGD6-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:16141072, ECO:0000269|PubMed:19468303};
CC IsoId=Q8VGD6-2; Sequence=VSP_046444;
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY073214; AAL60877.1; -; Genomic_DNA.
DR EMBL; AY318610; AAP71778.1; -; Genomic_DNA.
DR EMBL; AK053352; BAC35358.1; -; mRNA.
DR EMBL; AL627237; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL645688; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466575; EDL33775.1; -; Genomic_DNA.
DR EMBL; BC141219; AAI41220.1; -; mRNA.
DR EMBL; BC147437; AAI47438.1; -; mRNA.
DR EMBL; AF102533; AAD13325.1; -; mRNA.
DR EMBL; AF102535; AAD13327.1; -; mRNA.
DR EMBL; AF102537; AAD13329.1; -; mRNA.
DR CCDS; CCDS24597.2; -. [Q8VGD6-1]
DR RefSeq; NP_035129.1; NM_010999.2. [Q8VGD6-1]
DR AlphaFoldDB; Q8VGD6; -.
DR SMR; Q8VGD6; -.
DR STRING; 10090.ENSMUSP00000136647; -.
DR PaxDb; Q8VGD6; -.
DR PRIDE; Q8VGD6; -.
DR ProteomicsDB; 293511; -. [Q8VGD6-1]
DR ProteomicsDB; 293512; -. [Q8VGD6-2]
DR DNASU; 18356; -.
DR Ensembl; ENSMUST00000056759; ENSMUSP00000058544; ENSMUSG00000040328. [Q8VGD6-2]
DR Ensembl; ENSMUST00000102785; ENSMUSP00000099846; ENSMUSG00000040328. [Q8VGD6-2]
DR Ensembl; ENSMUST00000179282; ENSMUSP00000136647; ENSMUSG00000040328. [Q8VGD6-2]
DR Ensembl; ENSMUST00000203149; ENSMUSP00000145429; ENSMUSG00000040328. [Q8VGD6-1]
DR Ensembl; ENSMUST00000203810; ENSMUSP00000144951; ENSMUSG00000040328. [Q8VGD6-1]
DR Ensembl; ENSMUST00000238881; ENSMUSP00000158965; ENSMUSG00000040328. [Q8VGD6-1]
DR Ensembl; ENSMUST00000239127; ENSMUSP00000159088; ENSMUSG00000040328. [Q8VGD6-2]
DR GeneID; 18356; -.
DR KEGG; mmu:18356; -.
DR UCSC; uc007ipo.1; mouse. [Q8VGD6-1]
DR CTD; 18356; -.
DR MGI; MGI:1333785; Olfr56.
DR VEuPathDB; HostDB:ENSMUSG00000040328; -.
DR eggNOG; ENOG502SHXQ; Eukaryota.
DR GeneTree; ENSGT01050000244844; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8VGD6; -.
DR OMA; MGIWLNQ; -.
DR OrthoDB; 905402at2759; -.
DR PhylomeDB; Q8VGD6; -.
DR TreeFam; TF337295; -.
DR BioGRID-ORCS; 18356; 2 hits in 66 CRISPR screens.
DR ChiTaRS; Olfr56; mouse.
DR PRO; PR:Q8VGD6; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8VGD6; protein.
DR Bgee; ENSMUSG00000040328; Expressed in jejunum and 11 other tissues.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Disulfide bond;
KW G-protein coupled receptor; Membrane; Olfaction; Receptor;
KW Reference proteome; Sensory transduction; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..315
FT /note="Olfactory receptor 56"
FT /id="PRO_0000422155"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DISULFID 98..180
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VAR_SEQ 1..32
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072,
FT ECO:0000303|PubMed:19468303"
FT /id="VSP_046444"
FT CONFLICT 225
FT /note="A -> T (in Ref. 7; AAD13327)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 315 AA; 34994 MW; 80A8516DB31846B3 CRC64;
MGIWLNESSV DGFILLGIFS QSQTDLLLFS TVMLVFTVAL CGNVLLILLI YTDPRLHTPM
YFFLSQLSLM DLMLVCNIVP KMAVNFLSGR KSISFAGCGI QIGFFVSLVG SEGLLLGLMA
YDRYVAISHP LHYPILMSQK VCLQIAGSSW AFGILDGIIQ MVAAMSLPYC GSRYIDHFFC
EVPALLKLAC ADTSLFDTLL FACCVFMLLL PFSIIVTSYA RILGAVLRMH SAQSRKKALA
TCSSHLTAVS LFYGAAMFIY LRPRRYRAPS HDKVVSIFYT VLTPMLNPLI YSLRNREVMG
ALRKGLDRCR VGSQH
