OLF5_MOUSE
ID OLF5_MOUSE Reviewed; 312 AA.
AC Q60889; Q3MI75; Q8VGH4;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Olfactory receptor 5;
DE AltName: Full=Odorant receptor M41;
DE AltName: Full=Olfactory receptor 103-8;
GN Name=Olfr5; Synonyms=Mor103-8;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [3]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 132-243.
RC STRAIN=C57BL/6J;
RX PubMed=8570653; DOI=10.1073/pnas.93.2.884;
RA Sullivan S.L., Adamson M.C., Ressler K.J., Kozak C.A., Buck L.B.;
RT "The chromosomal distribution of mouse odorant receptor genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:884-888(1996).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY073174; AAL60837.1; -; Genomic_DNA.
DR EMBL; AY318553; AAP71729.1; -; Genomic_DNA.
DR EMBL; BC104074; AAI04075.1; -; mRNA.
DR EMBL; BC104075; AAI04076.1; -; mRNA.
DR EMBL; U28778; AAC52401.1; -; Genomic_DNA.
DR CCDS; CCDS57479.1; -.
DR RefSeq; NP_667125.1; NM_146914.2.
DR RefSeq; XP_011248755.1; XM_011250453.2.
DR AlphaFoldDB; Q60889; -.
DR SMR; Q60889; -.
DR STRING; 10090.ENSMUSP00000083498; -.
DR GlyGen; Q60889; 2 sites.
DR PaxDb; Q60889; -.
DR PRIDE; Q60889; -.
DR DNASU; 18349; -.
DR Ensembl; ENSMUST00000086318; ENSMUSP00000083498; ENSMUSG00000096228.
DR Ensembl; ENSMUST00000209866; ENSMUSP00000147586; ENSMUSG00000096228.
DR GeneID; 18349; -.
DR KEGG; mmu:18349; -.
DR UCSC; uc009fbo.2; mouse.
DR CTD; 18349; -.
DR MGI; MGI:106685; Olfr5.
DR VEuPathDB; HostDB:ENSMUSG00000096228; -.
DR eggNOG; ENOG502QW5T; Eukaryota.
DR GeneTree; ENSGT00940000162481; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q60889; -.
DR OMA; CFLMTMA; -.
DR OrthoDB; 997958at2759; -.
DR PhylomeDB; Q60889; -.
DR TreeFam; TF337475; -.
DR BioGRID-ORCS; 18349; 2 hits in 65 CRISPR screens.
DR PRO; PR:Q60889; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q60889; protein.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 5"
FT /id="PRO_0000150805"
FT TOPO_DOM 1..29
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..69
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 113..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..241
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 263..275
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 9
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 190
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 101..193
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 312 AA; 35281 MW; A74B9C481039AC07 CRC64;
MERSLALANM TRVQQFILLG LSTRLDIRDA LFAVFLTLYL LTLLENTLII YLICSHKELH
KPMYFFLGNL SCLEMCYVSV TMPTLLMGLW NGLYHIPFIA CMTQLFFFIV LVGTECILLA
SMAYDRYVAI CRPLHYPVLM RPQVCLGLAM ISWLGGLLVS MIKTTCIATL SYCGPNVLNH
FFCDVSPLLN LSCTHVALTE LVDFISAIVI LWGCFLTTMA SYVAIGRAVL RMPSTTARYK
AFSTCASHLV VVGIFYSVTI FIYARPKRIE AMDLNKVLSV IYTVVTPMCN PVIYCLRNKE
VQVALHRTMH WS
