OLF63_MOUSE
ID OLF63_MOUSE Reviewed; 316 AA.
AC Q8VBW9;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Olfactory receptor 63;
DE AltName: Full=Odorant receptor M4;
DE AltName: Full=Olfactory receptor 267-1;
GN Name=Olfr63; Synonyms=Mor267-1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6J;
RA Feinstein P., Mombaerts P.;
RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [4]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF281257; AAL36984.1; -; Genomic_DNA.
DR EMBL; AY073151; AAL60814.1; -; Genomic_DNA.
DR EMBL; AY317466; AAP70900.1; -; Genomic_DNA.
DR CCDS; CCDS37563.1; -.
DR RefSeq; NP_667148.1; NM_146937.1.
DR AlphaFoldDB; Q8VBW9; -.
DR SMR; Q8VBW9; -.
DR STRING; 10090.ENSMUSP00000067207; -.
DR GlyGen; Q8VBW9; 1 site.
DR iPTMnet; Q8VBW9; -.
DR PhosphoSitePlus; Q8VBW9; -.
DR PaxDb; Q8VBW9; -.
DR PRIDE; Q8VBW9; -.
DR DNASU; 258939; -.
DR Ensembl; ENSMUST00000067840; ENSMUSP00000067207; ENSMUSG00000054666.
DR Ensembl; ENSMUST00000217023; ENSMUSP00000150323; ENSMUSG00000054666.
DR GeneID; 258939; -.
DR KEGG; mmu:258939; -.
DR UCSC; uc008byg.1; mouse.
DR CTD; 258939; -.
DR MGI; MGI:1335096; Olfr63.
DR VEuPathDB; HostDB:ENSMUSG00000054666; -.
DR eggNOG; ENOG502SJHK; Eukaryota.
DR GeneTree; ENSGT01040000240424; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q8VBW9; -.
DR OMA; MSPHDCA; -.
DR OrthoDB; 970259at2759; -.
DR PhylomeDB; Q8VBW9; -.
DR TreeFam; TF338279; -.
DR BioGRID-ORCS; 258939; 3 hits in 66 CRISPR screens.
DR PRO; PR:Q8VBW9; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q8VBW9; protein.
DR ExpressionAtlas; Q8VBW9; baseline and differential.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; ISO:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISO:MGI.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISO:MGI.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; ISO:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..316
FT /note="Olfactory receptor 63"
FT /id="PRO_0000150815"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..144
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 166..207
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..228
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 229..241
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 263..273
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 295..316
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 98..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 316 AA; 35748 MW; 56D161EA4988EEBC CRC64;
MPGQNYSTIS EFILFGFSAF PHQMLPALFL LYLLMYLFTL LGNLVIMAAI WTEHRLHTPM
YLFLCALSIS EILFTVVITP RMLSDMLSTH RSITFIACAN QLFFSFTFGY THSFLLVVMG
YDRYVAICRP LHYHALMSLQ GCARLVAWSW AGGSLIGMAL TIIIFHLTFC ESNVIHHILC
HVFSLLKLAC GERTAFVTIA VILVCVTPLI GCLVFIILSY IFIVAAILRI PSTEGRHKTF
STCASHLTVV IVHYGFASII YLKSRGLYSQ YTDTLMSTTY TVFTPFLSPI IFSLRNKELK
NAIIKSFHRN VCQQSI
