OLF6_MOUSE
ID OLF6_MOUSE Reviewed; 316 AA.
AC P34986; A0PK63; Q9EPG1; Q9EPV0;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 2.
DT 25-MAY-2022, entry version 129.
DE RecName: Full=Olfactory receptor 6;
DE AltName: Full=Odorant receptor M50;
DE AltName: Full=Olfactory receptor 103-16;
GN Name=Olfr6; Synonyms=Mor103-16;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ, and C57BL/6J;
RX PubMed=11416212; DOI=10.1073/pnas.131215398;
RA Lane R.P., Cutforth T., Young J., Athanasiou M., Friedman C., Rowen L.,
RA Evans G., Axel R., Hood L., Trask B.J.;
RT "Genomic analysis of orthologous mouse and human olfactory receptor loci.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7390-7395(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ;
RX PubMed=11130974; DOI=10.1007/s003350010217;
RA Xie S.Y., Feinstein P., Mombaerts P.;
RT "Characterization of a cluster comprising 100 odorant receptor genes in
RT mouse.";
RL Mamm. Genome 11:1070-1078(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [5]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 59-280.
RC STRAIN=C57BL/6J; TISSUE=Liver;
RX PubMed=7683976; DOI=10.1016/0092-8674(93)90145-g;
RA Ressler K.J., Sullivan S.L., Buck L.B.;
RT "A zonal organization of odorant receptor gene expression in the olfactory
RT epithelium.";
RL Cell 73:597-609(1993).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Olfactory epithelium.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF321234; AAG45190.1; -; Genomic_DNA.
DR EMBL; AF321236; AAG45202.1; -; Genomic_DNA.
DR EMBL; AF293079; AAK97075.1; -; Genomic_DNA.
DR EMBL; AY073741; AAL61404.1; -; Genomic_DNA.
DR EMBL; AY317832; AAP71175.1; -; Genomic_DNA.
DR EMBL; BC127998; AAI27999.1; -; mRNA.
DR EMBL; L14567; AAA39851.1; -; Genomic_DNA.
DR CCDS; CCDS21681.1; -.
DR PIR; B40745; B40745.
DR RefSeq; NP_996780.2; NM_206897.2.
DR AlphaFoldDB; P34986; -.
DR SMR; P34986; -.
DR STRING; 10090.ENSMUSP00000048740; -.
DR GlyGen; P34986; 2 sites.
DR PaxDb; P34986; -.
DR PRIDE; P34986; -.
DR GeneID; 233670; -.
DR KEGG; mmu:233670; -.
DR UCSC; uc009jao.1; mouse.
DR CTD; 233670; -.
DR MGI; MGI:104713; Olfr6.
DR eggNOG; ENOG502SJJZ; Eukaryota.
DR InParanoid; P34986; -.
DR OrthoDB; 1148157at2759; -.
DR PhylomeDB; P34986; -.
DR TreeFam; TF337475; -.
DR BioGRID-ORCS; 233670; 4 hits in 65 CRISPR screens.
DR PRO; PR:P34986; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P34986; protein.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..316
FT /note="Olfactory receptor 6"
FT /id="PRO_0000150806"
FT TOPO_DOM 1..22
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 23..43
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 44..64
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 86..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..132
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 154..199
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..316
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 86
FT /note="R -> H (in Ref. 1; AAG45190 and 6; AAA39851)"
FT /evidence="ECO:0000305"
FT CONFLICT 161
FT /note="I -> L (in Ref. 1; AAG45190 and 6; AAA39851)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 316 AA; 35407 MW; 0BC490530EA531EE CRC64;
MENITNISEF ILMGFPTAPW LQILLFSIFF ITYVFVLLEN LVIILTVWVT GSLHKPMYYF
LSTMSFLEAW YISVTVPKML AGFLFRPNTI SFLGCMTQLY FFMSLACTEC VLLAAMAYDR
YVAICWPLRY PVMMTTGFCV QLTISSWVSG FTISMAKVYF ISRVAFCGNN VLNHFFCDVS
PILKLACMNL SMAETVDFAL AIVILIFPLS ATVLSYGFIV STVLQIPSAT GQRKAFSTCA
SHLTVVVIFY TAVIFMYVRP RAIASFNSNK LISAIYAVFT PMLNPIIYCL RNKEVKDAIR
KTIAGGRAPA LGESIS
