OLF8_MOUSE
ID OLF8_MOUSE Reviewed; 310 AA.
AC Q60892; Q7TQV0; Q9ERY5; Q9JM18;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Olfactory receptor 8;
DE AltName: Full=Odorant receptor M64;
GN Name=Olfr8;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14611657; DOI=10.1186/gb-2003-4-11-r71;
RA Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A.,
RA Walker M., Williams E.M., Trask B.J.;
RT "Odorant receptor expressed sequence tags demonstrate olfactory expression
RT of over 400 genes, extensive alternate splicing and unequal expression
RT levels.";
RL Genome Biol. 4:R71.1-R71.13(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 27-293.
RC STRAIN=BALB/cJ;
RX PubMed=11014824; DOI=10.1093/genetics/156.2.785;
RA Branscomb A., Seger J., White R.L.;
RT "Evolution of odorant receptors expressed in mammalian testes.";
RL Genetics 156:785-797(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-284.
RX PubMed=10706615; DOI=10.1073/pnas.040580197;
RA Rouquier S., Blancher A., Giorgi D.;
RT "The olfactory receptor gene repertoire in primates and mouse: evidence for
RT reduction of the functional fraction in primates.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:2870-2874(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 129-240.
RC STRAIN=C57BL/6J;
RX PubMed=8570653; DOI=10.1073/pnas.93.2.884;
RA Sullivan S.L., Adamson M.C., Ressler K.J., Kozak C.A., Buck L.B.;
RT "The chromosomal distribution of mouse odorant receptor genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:884-888(1996).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY318562; AAP71738.1; -; Genomic_DNA.
DR EMBL; AF271036; AAG21309.1; -; Genomic_DNA.
DR EMBL; AF073986; AAD43435.1; -; Genomic_DNA.
DR EMBL; U28781; AAC52404.1; -; Genomic_DNA.
DR CCDS; CCDS23971.1; -.
DR RefSeq; NP_997084.1; NM_207201.1.
DR AlphaFoldDB; Q60892; -.
DR SMR; Q60892; -.
DR STRING; 10090.ENSMUSP00000080282; -.
DR GlyGen; Q60892; 1 site.
DR PaxDb; Q60892; -.
DR PRIDE; Q60892; -.
DR DNASU; 18372; -.
DR Ensembl; ENSMUST00000081571; ENSMUSP00000080282; ENSMUSG00000094080.
DR Ensembl; ENSMUST00000203851; ENSMUSP00000144916; ENSMUSG00000094080.
DR Ensembl; ENSMUST00000214952; ENSMUSP00000148856; ENSMUSG00000094080.
DR GeneID; 18372; -.
DR KEGG; mmu:18372; -.
DR UCSC; uc007fyj.1; mouse.
DR CTD; 18372; -.
DR MGI; MGI:107174; Olfr8.
DR VEuPathDB; HostDB:ENSMUSG00000094080; -.
DR eggNOG; ENOG502RTYS; Eukaryota.
DR GeneTree; ENSGT00940000153523; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q60892; -.
DR OMA; SIFHAFI; -.
DR OrthoDB; 216949at32523; -.
DR PhylomeDB; Q60892; -.
DR TreeFam; TF337210; -.
DR BioGRID-ORCS; 18372; 2 hits in 63 CRISPR screens.
DR PRO; PR:Q60892; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q60892; protein.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Olfactory receptor 8"
FT /id="PRO_0000150807"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..67
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..135
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..202
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 98..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 82
FT /note="M -> V (in Ref. 3; AAD43435)"
FT /evidence="ECO:0000305"
FT CONFLICT 135
FT /note="F -> V (in Ref. 4; AAC52404)"
FT /evidence="ECO:0000305"
FT CONFLICT 140
FT /note="H -> Q (in Ref. 4; AAC52404)"
FT /evidence="ECO:0000305"
FT CONFLICT 191
FT /note="L -> S (in Ref. 4; AAC52404)"
FT /evidence="ECO:0000305"
FT CONFLICT 194
FT /note="L -> F (in Ref. 3 and 4)"
FT /evidence="ECO:0000305"
FT CONFLICT 197
FT /note="H -> Q (in Ref. 4; AAC52404)"
FT /evidence="ECO:0000305"
FT CONFLICT 237
FT /note="T -> K (in Ref. 3 and 4)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 310 AA; 34792 MW; 89D353E45254237D CRC64;
MESGNSTRRI PSFFLLGFSE NPHLQFLIFV LFLSMYLVTV LGNLLIIMVI ITQSPLHTPM
YFFLANLSFV DICFTSTTVP KMLVNIQTQS KAITYADCIS QMSVFLVFAE LDNFLLAVMA
YDRYVAICHP LYYTFIVNQH LCILMVLLSW VVSILHAFLQ SSIVLQLTFC GDVKIPHFFC
ELNQLSQLTC LDSLSSHLIM NLVPVLLAVI SFSSILYSYF KIVSSICSIS SVQGKYTAFS
TCVSHLSIVF LFYSTGLGVY VSSAVVQSSH SAARASVMYT VVTPMLNPFI YSLRNKDVKK
ALERLLEGKL
