ID   OLFA_LITPI              Reviewed;         177 AA.
AC   P06910;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1988, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Olfactory protein;
DE   Flags: Precursor;
OS   Lithobates pipiens (Northern leopard frog) (Rana pipiens).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Lithobates.
OX   NCBI_TaxID=8404;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Bowman gland;
RX   PubMed=3493528; DOI=10.1126/science.3493528;
RA   Lee K.-H., Wells R.G., Reed R.R.;
RT   "Isolation of an olfactory cDNA: similarity to retinol-binding protein
RT   suggests a role in olfaction.";
RL   Science 235:1053-1056(1987).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Synthesized in Bowman glands, which secrete the
CC       mucus that bathes the cilia of the olfactory neuroepithelium.
CC       {ECO:0000269|PubMed:3493528}.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC       {ECO:0000305}.
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DR   EMBL; M15531; AAA49529.1; -; mRNA.
DR   PIR; A25837; OVFGP.
DR   AlphaFoldDB; P06910; -.
DR   SMR; P06910; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR002968; A1-microglobln.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR002345; Lipocalin.
DR   InterPro; IPR022272; Lipocalin_CS.
DR   InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR   PANTHER; PTHR11430; PTHR11430; 1.
DR   Pfam; PF00061; Lipocalin; 1.
DR   PRINTS; PR01215; A1MCGLOBULIN.
DR   SUPFAM; SSF50814; SSF50814; 1.
DR   PROSITE; PS00213; LIPOCALIN; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Olfaction; Secreted; Sensory transduction; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..177
FT                   /note="Olfactory protein"
FT                   /id="PRO_0000017939"
FT   DISULFID        81..174
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   177 AA;  20192 MW;  61499AF22E72D251 CRC64;
     MIRIIAIVVL FFLQCQADLP PVMKGLEENK VTGVWYGIAA ASNCKQFLQM KSDNMPAPVN
     IYSLNNGHMK SSTSFQTEKG CQQMDVEMTT VEKGHYKWKM QQGDSETIIV ATDYDAFLME
     FTKIQMGAEV CVTVKLFGRK DTLPEDKIKH FEDHIEKVGL KKEQYIRFHT KATCVPK