OLFL1_HUMAN
ID OLFL1_HUMAN Reviewed; 402 AA.
AC Q6UWY5; B4DP03; Q569G4;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Olfactomedin-like protein 1;
DE Flags: Precursor;
GN Name=OLFML1; ORFNames=UNQ564/PRO1126;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-113.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT VAL-113.
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-113.
RC TISSUE=Pancreas, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PROTEIN SEQUENCE OF 29-43.
RX PubMed=15340161; DOI=10.1110/ps.04682504;
RA Zhang Z., Henzel W.J.;
RT "Signal peptide prediction based on analysis of experimentally verified
RT cleavage sites.";
RL Protein Sci. 13:2819-2824(2004).
RN [6]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND GLYCOSYLATION.
RX PubMed=18708057; DOI=10.1016/j.febslet.2008.08.009;
RA Wan B., Zhou Y.B., Zhang X., Zhu H., Huo K., Han Z.G.;
RT "hOLFML1, a novel secreted glycoprotein, enhances the proliferation of
RT human cancer cell lines in vitro.";
RL FEBS Lett. 582:3185-3192(2008).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18708057}.
CC -!- TISSUE SPECIFICITY: Mainly expressed in the small intestine, liver,
CC lung and heart. {ECO:0000269|PubMed:18708057}.
CC -!- PTM: Highly N-glycosylated. {ECO:0000269|PubMed:18708057}.
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DR EMBL; AY358591; AAQ88954.1; -; mRNA.
DR EMBL; AK298137; BAG60415.1; -; mRNA.
DR EMBL; AC107884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC035895; AAH35895.1; -; mRNA.
DR EMBL; BC092488; AAH92488.1; -; mRNA.
DR CCDS; CCDS7779.1; -.
DR RefSeq; NP_940876.2; NM_198474.3.
DR RefSeq; XP_005252935.1; XM_005252878.4.
DR AlphaFoldDB; Q6UWY5; -.
DR SMR; Q6UWY5; -.
DR STRING; 9606.ENSP00000332511; -.
DR GlyConnect; 1586; 5 N-Linked glycans (2 sites).
DR GlyGen; Q6UWY5; 3 sites, 4 N-linked glycans (2 sites).
DR iPTMnet; Q6UWY5; -.
DR PhosphoSitePlus; Q6UWY5; -.
DR BioMuta; OLFML1; -.
DR DMDM; 308153468; -.
DR jPOST; Q6UWY5; -.
DR MassIVE; Q6UWY5; -.
DR PaxDb; Q6UWY5; -.
DR PeptideAtlas; Q6UWY5; -.
DR PRIDE; Q6UWY5; -.
DR ProteomicsDB; 67538; -.
DR Antibodypedia; 42313; 77 antibodies from 13 providers.
DR DNASU; 283298; -.
DR Ensembl; ENST00000329293.4; ENSP00000332511.3; ENSG00000183801.8.
DR Ensembl; ENST00000530135.5; ENSP00000433455.1; ENSG00000183801.8.
DR GeneID; 283298; -.
DR KEGG; hsa:283298; -.
DR MANE-Select; ENST00000329293.4; ENSP00000332511.3; NM_198474.4; NP_940876.2.
DR UCSC; uc001mfi.4; human.
DR CTD; 283298; -.
DR DisGeNET; 283298; -.
DR GeneCards; OLFML1; -.
DR HGNC; HGNC:24473; OLFML1.
DR HPA; ENSG00000183801; Tissue enhanced (ovary).
DR neXtProt; NX_Q6UWY5; -.
DR OpenTargets; ENSG00000183801; -.
DR PharmGKB; PA134904379; -.
DR VEuPathDB; HostDB:ENSG00000183801; -.
DR eggNOG; KOG3545; Eukaryota.
DR GeneTree; ENSGT00940000160055; -.
DR HOGENOM; CLU_035236_2_0_1; -.
DR InParanoid; Q6UWY5; -.
DR OMA; IHYHPGD; -.
DR OrthoDB; 421994at2759; -.
DR PhylomeDB; Q6UWY5; -.
DR TreeFam; TF352000; -.
DR PathwayCommons; Q6UWY5; -.
DR BioGRID-ORCS; 283298; 16 hits in 1063 CRISPR screens.
DR ChiTaRS; OLFML1; human.
DR GenomeRNAi; 283298; -.
DR Pharos; Q6UWY5; Tdark.
DR PRO; PR:Q6UWY5; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q6UWY5; protein.
DR Bgee; ENSG00000183801; Expressed in parietal pleura and 145 other tissues.
DR ExpressionAtlas; Q6UWY5; baseline and differential.
DR Genevisible; Q6UWY5; HS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR003112; Olfac-like_dom.
DR InterPro; IPR031229; OLFML1.
DR PANTHER; PTHR23192:SF13; PTHR23192:SF13; 1.
DR Pfam; PF02191; OLF; 1.
DR SMART; SM00284; OLF; 1.
DR PROSITE; PS51132; OLF; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Direct protein sequencing; Disulfide bond; Glycoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..28
FT /evidence="ECO:0000269|PubMed:15340161"
FT CHAIN 29..402
FT /note="Olfactomedin-like protein 1"
FT /id="PRO_0000020090"
FT DOMAIN 140..397
FT /note="Olfactomedin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00446"
FT COILED 79..133
FT /evidence="ECO:0000255"
FT CARBOHYD 66
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 138
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 183
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 141..324
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00446"
FT VARIANT 113
FT /note="E -> V (in dbSNP:rs12805648)"
FT /evidence="ECO:0000269|PubMed:12975309,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:16554811"
FT /id="VAR_034362"
FT VARIANT 259
FT /note="A -> T (in dbSNP:rs12803046)"
FT /id="VAR_034363"
SQ SEQUENCE 402 AA; 45951 MW; FB767C162E8D14D0 CRC64;
MMVALRGASA LLVLFLAAFL PPPQCTQDPA MVHYIYQRFR VLEQGLEKCT QATRAYIQEF
QEFSKNISVM LGRCQTYTSE YKSAVGNLAL RVERAQREID YIQYLREADE CIESEDKTLA
EMLLQEAEEE KKIRTLLNAS CDNMLMGIKS LKIVKKMMDT HGSWMKDAVY NSPKVYLLIG
SRNNTVWEFA NIRAFMEDNT KPAPRKQILT LSWQGTGQVI YKGFLFFHNQ ATSNEIIKYN
LQKRTVEDRM LLPGGVGRAL VYQHSPSTYI DLAVDEHGLW AIHSGPGTHS HLVLTKIEPG
TLGVEHSWDT PCRSQDAEAS FLLCGVLYVV YSTGGQGPHR ITCIYDPLGT ISEEDLPNLF
FPKRPRSHSM IHYNPRDKQL YAWNEGNQII YKLQTKRKLP LK
