ID   OLFL3_BOVIN             Reviewed;         406 AA.
AC   Q0VCP3;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Olfactomedin-like protein 3;
DE   Flags: Precursor;
GN   Name=OLFML3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal pons;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Secreted scaffold protein that plays an essential role in
CC       dorsoventral patterning during early development. Stabilizes axial
CC       formation by restricting chordin (CHRD) activity on the dorsal side.
CC       Acts by facilitating the association between the tolloid proteases and
CC       their substrate chordin (CHRD), leading to enhance chordin (CHRD)
CC       degradation (By similarity). May have matrix-related function involved
CC       in placental and embryonic development, or play a similar role in other
CC       physiological processes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OLFML3 family. {ECO:0000305}.
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DR   EMBL; BC120075; AAI20076.1; -; mRNA.
DR   RefSeq; NP_001068665.1; NM_001075197.1.
DR   AlphaFoldDB; Q0VCP3; -.
DR   SMR; Q0VCP3; -.
DR   STRING; 9913.ENSBTAP00000015056; -.
DR   PaxDb; Q0VCP3; -.
DR   PRIDE; Q0VCP3; -.
DR   GeneID; 505318; -.
DR   KEGG; bta:505318; -.
DR   CTD; 56944; -.
DR   eggNOG; KOG3545; Eukaryota.
DR   HOGENOM; CLU_035236_2_1_1; -.
DR   InParanoid; Q0VCP3; -.
DR   OrthoDB; 421994at2759; -.
DR   TreeFam; TF352000; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   InterPro; IPR003112; Olfac-like_dom.
DR   InterPro; IPR031230; OLFML3.
DR   PANTHER; PTHR23192:SF8; PTHR23192:SF8; 1.
DR   Pfam; PF02191; OLF; 1.
DR   SMART; SM00284; OLF; 1.
DR   PROSITE; PS51132; OLF; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Developmental protein; Disulfide bond; Glycoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..406
FT                   /note="Olfactomedin-like protein 3"
FT                   /id="PRO_0000361560"
FT   DOMAIN          134..401
FT                   /note="Olfactomedin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00446"
FT   COILED          22..101
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        248
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        135..328
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00446"
SQ   SEQUENCE   406 AA;  45886 MW;  A97CB88514FE7338 CRC64;
     MGPHTQLLIL LLLSWLGPLQ GQQHHLVEYM ERRLAALEER LAQCQDQSSR HAAELRDFKN
     KMLPLLEVAE KEREALRTEA DTISGRVDRL EREVDYLETQ NPALPCVEVD EKVTGGPGTK
     GKGRRNEKYD MITDCGYTIS QVRSMKILKR FGGPAGLWTK DPLGPAEKIY VLDGTQNDTA
     FVFPRLRDFT LAMAARKASR VRVPFPWVGT GQLVYGGFLY YARRPPGGPG GGGELQNTLQ
     LIKFHLANRT VVDSSVFPAE GLIPPYGLTA DTYIDLAADE EGLWAVYATR EDDRHLCLAK
     LDPQTLDTEQ QWDTPCPREN AEAAFVICGT LYVVYNTRPA SRARIQCSFD ASGTLTPERA
     ALPYFPRRYG AHASLRYNPR ERQLYAWDDG YQIVYKLEMR KKEEEV