ID   OLFL3_CHICK             Reviewed;         392 AA.
AC   Q25C36;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Olfactomedin-like protein 3;
DE   AltName: Full=Olfactomedin-noelin-tiarin factor 1;
DE   Flags: Precursor;
GN   Name=OLFML3; Synonyms=ONT1;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=16412616; DOI=10.1016/j.mod.2005.11.005;
RA   Sakuragi M., Sasai N., Ikeya M., Kawada M., Onai T., Katahira T.,
RA   Nakamura H., Sasai Y.;
RT   "Functional analysis of chick ONT1 reveals distinguishable activities among
RT   olfactomedin-related signaling factors.";
RL   Mech. Dev. 123:114-123(2006).
CC   -!- FUNCTION: Secreted scaffold protein that plays an essential role in
CC       dorsoventral patterning during early development. Stabilizes axial
CC       formation by restricting chordin (CHRD) activity on the dorsal side.
CC       Acts by facilitating the association between the tolloid proteases and
CC       their substrate chordin (CHRD), leading to enhance chordin (CHRD)
CC       degradation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expression first appears at Hensen's node and
CC       subsequently in the axial and paraxial mesoderm. When the neural tube
CC       closes, strong expression is transiently found in the roof plate region
CC       from the rostral midbrain to the hindbrain.
CC       {ECO:0000269|PubMed:16412616}.
CC   -!- SIMILARITY: Belongs to the OLFML3 family. {ECO:0000305}.
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DR   EMBL; AB236173; BAE91905.1; -; mRNA.
DR   RefSeq; NP_001035107.1; NM_001040018.1.
DR   AlphaFoldDB; Q25C36; -.
DR   SMR; Q25C36; -.
DR   STRING; 9031.ENSGALP00000003021; -.
DR   PaxDb; Q25C36; -.
DR   Ensembl; ENSGALT00000003025; ENSGALP00000003021; ENSGALG00000001956.
DR   GeneID; 419882; -.
DR   KEGG; gga:419882; -.
DR   CTD; 56944; -.
DR   VEuPathDB; HostDB:geneid_419882; -.
DR   eggNOG; KOG3545; Eukaryota.
DR   GeneTree; ENSGT00940000158083; -.
DR   HOGENOM; CLU_035236_2_1_1; -.
DR   InParanoid; Q25C36; -.
DR   OMA; SQWHDQS; -.
DR   OrthoDB; 421994at2759; -.
DR   PhylomeDB; Q25C36; -.
DR   TreeFam; TF352000; -.
DR   PRO; PR:Q25C36; -.
DR   Proteomes; UP000000539; Chromosome 26.
DR   Bgee; ENSGALG00000001956; Expressed in ovary and 12 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   InterPro; IPR003112; Olfac-like_dom.
DR   InterPro; IPR031230; OLFML3.
DR   PANTHER; PTHR23192:SF8; PTHR23192:SF8; 1.
DR   Pfam; PF02191; OLF; 1.
DR   SMART; SM00284; OLF; 1.
DR   PROSITE; PS51132; OLF; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Developmental protein; Disulfide bond; Glycoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..392
FT                   /note="Olfactomedin-like protein 3"
FT                   /id="PRO_0000361562"
FT   DOMAIN          132..388
FT                   /note="Olfactomedin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00446"
FT   COILED          25..99
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        175
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        235
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        133..315
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00446"
SQ   SEQUENCE   392 AA;  44846 MW;  A06AC77840E2012E CRC64;
     MGPWRCLLLL PLLAAAPRAQ QQQFMEYVER RLALLEERIA QWHDQSSRYS TELRDFKNQV
     LGMLETAEKE REALRAEAEG AAARVDRLER EVDYLETQNP APPCVEVDEV LMEKQAATAK
     QRKNEKYTKL TDCSDTIASV RAMKILKRFG SSAGLWTKDA AGSSEKIYVF DGTANDTVYI
     FPRMREFTLF SATRRAARIK LPYPWVGTGH LVYGGYLYYI RQQGPFQVIK FDLANKTVVD
     SSVFPAEEQI PVFGLSPFTY IELAADEEGL WAIYATKENE KNICLAKLDP DSLDIEQMWD
     TPCPRENAEG AFVVCGALHV AYNTRLPSRS RVQCVFDVSG TLPPEEASLV YFPKRYGSHS
     SMKYSPRERQ VYAWDDGYQI IYRMEMKKKL EV