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OLFL3_MOUSE
ID   OLFL3_MOUSE             Reviewed;         406 AA.
AC   Q8BK62; A9R9W9; Q3V2F2; Q8C1T0; Q99K37;
DT   21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2009, sequence version 2.
DT   25-MAY-2022, entry version 116.
DE   RecName: Full=Olfactomedin-like protein 3;
DE   Flags: Precursor;
GN   Name=Olfml3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Embryo, Kidney, and Stomach;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Secreted scaffold protein that plays an essential role in
CC       dorsoventral patterning during early development. Stabilizes axial
CC       formation by restricting chordin (CHRD) activity on the dorsal side.
CC       Acts by facilitating the association between the tolloid proteases and
CC       their substrate chordin (CHRD), leading to enhance chordin (CHRD)
CC       degradation (By similarity). May have matrix-related function involved
CC       in placental and embryonic development, or play a similar role in other
CC       physiological processes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OLFML3 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC24996.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AK002518; BAC24996.1; ALT_FRAME; mRNA.
DR   EMBL; AK076084; BAC36170.1; -; mRNA.
DR   EMBL; AK131879; BAE20846.1; -; mRNA.
DR   EMBL; CU210935; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC005485; AAH05485.1; -; mRNA.
DR   CCDS; CCDS17693.1; -.
DR   RefSeq; NP_598620.2; NM_133859.2.
DR   AlphaFoldDB; Q8BK62; -.
DR   SMR; Q8BK62; -.
DR   BioGRID; 221282; 2.
DR   STRING; 10090.ENSMUSP00000029440; -.
DR   GlyGen; Q8BK62; 2 sites.
DR   iPTMnet; Q8BK62; -.
DR   PhosphoSitePlus; Q8BK62; -.
DR   CPTAC; non-CPTAC-3476; -.
DR   MaxQB; Q8BK62; -.
DR   PaxDb; Q8BK62; -.
DR   PeptideAtlas; Q8BK62; -.
DR   PRIDE; Q8BK62; -.
DR   ProteomicsDB; 294197; -.
DR   GeneID; 99543; -.
DR   KEGG; mmu:99543; -.
DR   UCSC; uc008qte.1; mouse.
DR   CTD; 56944; -.
DR   MGI; MGI:1914877; Olfml3.
DR   eggNOG; KOG3545; Eukaryota.
DR   InParanoid; Q8BK62; -.
DR   OrthoDB; 421994at2759; -.
DR   PhylomeDB; Q8BK62; -.
DR   TreeFam; TF352000; -.
DR   BioGRID-ORCS; 99543; 1 hit in 69 CRISPR screens.
DR   ChiTaRS; Olfml3; mouse.
DR   PRO; PR:Q8BK62; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q8BK62; protein.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   InterPro; IPR003112; Olfac-like_dom.
DR   InterPro; IPR031230; OLFML3.
DR   PANTHER; PTHR23192:SF8; PTHR23192:SF8; 1.
DR   Pfam; PF02191; OLF; 1.
DR   SMART; SM00284; OLF; 1.
DR   PROSITE; PS51132; OLF; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Developmental protein; Disulfide bond; Glycoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..406
FT                   /note="Olfactomedin-like protein 3"
FT                   /id="PRO_0000020093"
FT   DOMAIN          134..401
FT                   /note="Olfactomedin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00446"
FT   COILED          25..101
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        177
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        248
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        135..328
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00446"
FT   CONFLICT        51
FT                   /note="L -> H (in Ref. 1; BAC24996/BAC36170/BAE20846 and 3;
FT                   AAH05485)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        155
FT                   /note="A -> V (in Ref. 1; BAC24996/BAC36170/BAE20846)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   406 AA;  45746 MW;  4BD11DD376F0A684 CRC64;
     MGPSAPLLLL FFLSWTGPLQ GQQHHLVEYM ERRLAALEER LAQCQDQSSR LAAELRDFKN
     KMLPLLEVAE KERETLRTEA DSISGRVDRL EREVDYLETQ NPALPCVELD EKVTGGPGAK
     GKGRRNEKYD MVTDCSYTVA QVRSMKILKR FGGSAGLWTK DPLGPAEKIY VLDGTQNDTA
     FVFPRLRDFT LAMAARKASR IRVPFPWVGT GQLVYGGFLY YARRPPGGPG GGGELENTLQ
     LIKFHLANRT VVDSSVFPAE SLIPPYGLTA DTYIDLAADE EGLWAVYATR DDDRHLCLAK
     LDPQTLDTEQ QWDTPCPREN AEAAFVICGT LYVVYNTRPA SRARIQCSFD ASGTLAPERA
     ALSYFPRRYG AHASLRYNPR ERQLYAWDDG YQIVYKLEMK KKEEEV
 
 
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