ID   OLFL3_XENTR             Reviewed;         416 AA.
AC   Q0V9V5;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Olfactomedin-like protein 3;
DE   Flags: Precursor;
GN   Name=olfml3;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Secreted scaffold protein that plays an essential role in
CC       dorsoventral patterning during early development. Stabilizes axial
CC       formation by restricting chordin (CHRD) activity on the dorsal side.
CC       Acts by facilitating the association between the tolloid protease BMP1
CC       and its substrate chordin (CHRD), leading to enhance chordin (CHRD)
CC       degradation by BMP1 (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts (via coiled coil domain) with BMP1 and (via
CC       olfactomedin-like domain) CHRD. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OLFML3 family. {ECO:0000305}.
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DR   EMBL; BC121380; AAI21381.1; -; mRNA.
DR   RefSeq; NP_001072318.1; NM_001078850.1.
DR   AlphaFoldDB; Q0V9V5; -.
DR   SMR; Q0V9V5; -.
DR   STRING; 8364.ENSXETP00000003568; -.
DR   PaxDb; Q0V9V5; -.
DR   DNASU; 779771; -.
DR   Ensembl; ENSXETT00000003568; ENSXETP00000003568; ENSXETG00000001697.
DR   GeneID; 779771; -.
DR   KEGG; xtr:779771; -.
DR   CTD; 56944; -.
DR   Xenbase; XB-GENE-1003397; olfml3.
DR   eggNOG; KOG3545; Eukaryota.
DR   HOGENOM; CLU_035236_2_1_1; -.
DR   InParanoid; Q0V9V5; -.
DR   OMA; SQWHDQS; -.
DR   OrthoDB; 421994at2759; -.
DR   PhylomeDB; Q0V9V5; -.
DR   TreeFam; TF352000; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000001697; Expressed in heart and 8 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR   InterPro; IPR003112; Olfac-like_dom.
DR   InterPro; IPR031230; OLFML3.
DR   PANTHER; PTHR23192:SF8; PTHR23192:SF8; 1.
DR   Pfam; PF02191; OLF; 1.
DR   SMART; SM00284; OLF; 1.
DR   SUPFAM; SSF50965; SSF50965; 1.
DR   PROSITE; PS51132; OLF; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Developmental protein; Disulfide bond; Glycoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..416
FT                   /note="Olfactomedin-like protein 3"
FT                   /id="PRO_0000361566"
FT   DOMAIN          155..411
FT                   /note="Olfactomedin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00446"
FT   COILED          48..129
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        198
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        258
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        156..338
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00446"
SQ   SEQUENCE   416 AA;  47756 MW;  3C0AC7A5C163153F CRC64;
     MAGIVACILL VFVTVITAQQ QAVFLEYIQG RMGVLEERLS QWHDQSSRYS GELRDFKNQV
     LKMLENIEKE RESLRNEMEN TNVRVDRLER EVDYIETQNP APPCVEIDEK LTELHDAKKK
     KKEKYEKITG CPAADIPGKE ETDEILIPPV IRKPYCSDTI SQVTAMKILK RFGSSAGLWT
     KDLAGNSDRI YVFDGAGNDT VYVYPRMKEF TLSSSTRKAA KIKLPFPWIG TGHIVYDGNL
     YYIRQDNEFQ VIKFNLANKT IIDSAVLPIE QQVPVYGLSK FNYIDIVADE EGLWVIYATK
     ENEKNICLAK LDPSSLSIEQ MWDTPCPIEN AESAFVVCGS LYVVYNTKLP SRSRIQCVFD
     VSGTISSENV PIVYFPKRYG SHSSMKYNPK EKQIYAWDDG YQMLYKLNMK HRDELY