ID   OLFM_LITCT              Reviewed;         464 AA.
AC   Q07081;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Olfactomedin;
DE   AltName: Full=Olfactory mucus protein;
DE   Flags: Precursor;
OS   Lithobates catesbeianus (American bullfrog) (Rana catesbeiana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Lithobates.
OX   NCBI_TaxID=8400;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 17-33 AND 35-37.
RC   TISSUE=Olfactory neuroepithelium;
RX   PubMed=8506313; DOI=10.1073/pnas.90.10.4655;
RA   Yokoe H., Anholt R.R.H.;
RT   "Molecular cloning of olfactomedin, an extracellular matrix protein
RT   specific to olfactory neuroepithelium.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:4655-4659(1993).
RN   [2]
RP   PROTEIN SEQUENCE OF 17-37, AND GLYCOSYLATION.
RC   TISSUE=Olfactory neuroepithelium;
RX   PubMed=8424933; DOI=10.1021/bi00055a008;
RA   Bal R.S., Anholt R.R.H.;
RT   "Formation of the extracellular mucous matrix of olfactory neuroepithelium:
RT   identification of partially glycosylated and nonglycosylated precursors of
RT   olfactomedin.";
RL   Biochemistry 32:1047-1053(1993).
CC   -!- FUNCTION: May influence the maintenance, growth, or differentiation of
CC       chemosensory cilia on the apical dendrites of olfactory neurons. Major
CC       component of the extracellular matrix of the olfactory neuroepithelium.
CC   -!- SUBUNIT: Oligomer; disulfide-linked.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space.
CC   -!- TISSUE SPECIFICITY: Expressed exclusively in olfactory neuroepithelium.
CC   -!- PTM: Most, if not all, of the six potential sites for N-glycosylation
CC       carry carbohydrate moieties of 8-10 sugar residues.
CC       {ECO:0000269|PubMed:8424933}.
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DR   EMBL; L13595; AAA49527.1; -; mRNA.
DR   PIR; A47442; A47442.
DR   AlphaFoldDB; Q07081; -.
DR   SMR; Q07081; -.
DR   iPTMnet; Q07081; -.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
DR   InterPro; IPR003112; Olfac-like_dom.
DR   InterPro; IPR031221; Olfactomedin-4.
DR   PANTHER; PTHR23192:SF7; PTHR23192:SF7; 1.
DR   Pfam; PF02191; OLF; 1.
DR   SMART; SM00284; OLF; 1.
DR   PROSITE; PS51132; OLF; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein; Olfaction;
KW   Secreted; Sensory transduction; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000269|PubMed:8424933,
FT                   ECO:0000269|PubMed:8506313"
FT   CHAIN           17..464
FT                   /note="Olfactomedin"
FT                   /id="PRO_0000020089"
FT   DOMAIN          192..464
FT                   /note="Olfactomedin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00446"
FT   CARBOHYD        21
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:8424933"
FT   CARBOHYD        85
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        143
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        228
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        279
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        383
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        193..394
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00446"
SQ   SEQUENCE   464 AA;  52572 MW;  CE5C617E40079864 CRC64;
     MYICLLTLVL IHAAAAFVAQ NATGILAGKD HCVCEVLLPD SSFPAKRVGA LEDETIRLSN
     RVEDEMQKLE EQDIILDTYS EKIINLTRRV EYLEKLHPES LVEISFEVLK REIRELEMYI
     SAMRVKPNGN SVQVETLYNE VKNMSKTVGQ LETLDKNNVL QAKREIVNLK KRLVDCEKNL
     KAKPSLMVPL GSCQHQGLAH ISKPNLMQLN WKGNAYKSGA WGKDAAWNTT KKSLYWVAPL
     NTDGRVLESI RIYPSMSDLQ MYKNPIDLPL SMLIKNKLNN TFAGQGAGVV VHNNNLYYNC
     FNSHDMCRAS LTSGVYQKKP LLNALFNNRF SYAGTMFQDM DFSSDEKGLW VIFTTEKSAG
     KIVVGKVNVA TFTVDNIWIT TQNKSDASNA FMICGVLYVT RSLGPKMEEV FYMFDTKTGK
     EGHLSIMMEK MAEKVHSLSY NSNDRKLYMF SEGYLLHYDI ALKP