OLIG1_HUMAN
ID OLIG1_HUMAN Reviewed; 271 AA.
AC Q8TAK6; Q7RTS0;
DT 30-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT 30-AUG-2002, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Oligodendrocyte transcription factor 1;
DE Short=Oligo1;
DE AltName: Full=Class B basic helix-loop-helix protein 6;
DE Short=bHLHb6;
DE AltName: Full=Class E basic helix-loop-helix protein 21;
DE Short=bHLHe21;
GN Name=OLIG1; Synonyms=BHLHB6, BHLHE21;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10830953; DOI=10.1038/35012518;
RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT "The DNA sequence of human chromosome 21.";
RL Nature 405:311-319(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14516699; DOI=10.1016/s0925-4773(03)00130-8;
RA McLellan A.S., Langlands K., Kealey T.;
RT "Exhaustive identification of human class II basic helix-loop-helix
RT proteins by virtual library screening.";
RL Mech. Dev. 119:S285-S291(2002).
RN [5]
RP FUNCTION.
RX PubMed=10719889; DOI=10.1016/s0896-6273(00)80898-3;
RA Zhou Q., Wang S., Anderson D.J.;
RT "Identification of a novel family of oligodendrocyte lineage-specific basic
RT helix-loop-helix transcription factors.";
RL Neuron 25:331-343(2000).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=11526205; DOI=10.1073/pnas.181340798;
RA Lu Q.R., Park J.K., Noll E., Chan J.A., Alberta J.A., Yuk D.-I.,
RA Alzamora M.G., Louis D.N., Stiles C.D., Rowitch D.H., Black P.M.;
RT "Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial
RT brain tumors.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:10851-10856(2001).
CC -!- FUNCTION: Promotes formation and maturation of oligodendrocytes,
CC especially within the brain. Cooperates with OLIG2 to establish the pMN
CC domain of the embryonic neural tube (By similarity). {ECO:0000250,
CC ECO:0000269|PubMed:10719889}.
CC -!- INTERACTION:
CC Q8TAK6; Q14451: GRB7; NbExp=3; IntAct=EBI-3867416, EBI-970191;
CC Q8TAK6; P08631-2: HCK; NbExp=2; IntAct=EBI-3867416, EBI-9834454;
CC Q8TAK6; Q92569: PIK3R3; NbExp=2; IntAct=EBI-3867416, EBI-79893;
CC Q8TAK6; O14796: SH2D1B; NbExp=2; IntAct=EBI-3867416, EBI-3923013;
CC Q8TAK6; Q15796: SMAD2; NbExp=2; IntAct=EBI-3867416, EBI-1040141;
CC Q8TAK6; P07947: YES1; NbExp=3; IntAct=EBI-3867416, EBI-515331;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- TISSUE SPECIFICITY: Expressed in the brain, in oligodendrocytes.
CC Strongly expressed in oligodendrogliomas, while expression is weak to
CC moderate in astrocytomas. Expression in glioblastomas is highly
CC variable. {ECO:0000269|PubMed:11526205}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH26989.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=DAA01058.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL834450; CAD39110.1; -; mRNA.
DR EMBL; AP000289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC026989; AAH26989.1; ALT_INIT; mRNA.
DR EMBL; BC033290; AAH33290.1; -; mRNA.
DR EMBL; BK000278; DAA01058.1; ALT_INIT; mRNA.
DR CCDS; CCDS42920.2; -.
DR RefSeq; NP_620450.2; NM_138983.2.
DR AlphaFoldDB; Q8TAK6; -.
DR SMR; Q8TAK6; -.
DR BioGRID; 125511; 28.
DR IntAct; Q8TAK6; 22.
DR MINT; Q8TAK6; -.
DR STRING; 9606.ENSP00000371785; -.
DR iPTMnet; Q8TAK6; -.
DR PhosphoSitePlus; Q8TAK6; -.
DR BioMuta; OLIG1; -.
DR DMDM; 22653884; -.
DR MassIVE; Q8TAK6; -.
DR PaxDb; Q8TAK6; -.
DR PeptideAtlas; Q8TAK6; -.
DR PRIDE; Q8TAK6; -.
DR ProteomicsDB; 73889; -.
DR TopDownProteomics; Q8TAK6; -.
DR Antibodypedia; 22667; 358 antibodies from 40 providers.
DR DNASU; 116448; -.
DR Ensembl; ENST00000382348.2; ENSP00000371785.1; ENSG00000184221.13.
DR GeneID; 116448; -.
DR KEGG; hsa:116448; -.
DR MANE-Select; ENST00000382348.2; ENSP00000371785.1; NM_138983.3; NP_620450.2.
DR UCSC; uc002yqz.4; human.
DR CTD; 116448; -.
DR DisGeNET; 116448; -.
DR GeneCards; OLIG1; -.
DR HGNC; HGNC:16983; OLIG1.
DR HPA; ENSG00000184221; Tissue enriched (brain).
DR MIM; 606385; gene.
DR neXtProt; NX_Q8TAK6; -.
DR OpenTargets; ENSG00000184221; -.
DR PharmGKB; PA31918; -.
DR VEuPathDB; HostDB:ENSG00000184221; -.
DR eggNOG; KOG3898; Eukaryota.
DR GeneTree; ENSGT00940000162722; -.
DR HOGENOM; CLU_060337_0_0_1; -.
DR InParanoid; Q8TAK6; -.
DR OMA; AHCQSSP; -.
DR OrthoDB; 1205889at2759; -.
DR PhylomeDB; Q8TAK6; -.
DR TreeFam; TF322733; -.
DR PathwayCommons; Q8TAK6; -.
DR SignaLink; Q8TAK6; -.
DR SIGNOR; Q8TAK6; -.
DR BioGRID-ORCS; 116448; 13 hits in 1088 CRISPR screens.
DR GeneWiki; OLIG1; -.
DR GenomeRNAi; 116448; -.
DR Pharos; Q8TAK6; Tbio.
DR PRO; PR:Q8TAK6; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; Q8TAK6; protein.
DR Bgee; ENSG00000184221; Expressed in inferior vagus X ganglion and 120 other tissues.
DR ExpressionAtlas; Q8TAK6; baseline and differential.
DR Genevisible; Q8TAK6; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0048663; P:neuron fate commitment; IEA:Ensembl.
DR GO; GO:0014003; P:oligodendrocyte development; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR032657; Olig1.
DR PANTHER; PTHR19290:SF7; PTHR19290:SF7; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..271
FT /note="Oligodendrocyte transcription factor 1"
FT /id="PRO_0000127411"
FT DOMAIN 105..164
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 38..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..117
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 271 AA; 27905 MW; 7CB9D8DD9CBA0DF5 CRC64;
MYYAVSQARV NAVPGTMLRP QRPGDLQLGA SLYELVGYRQ PPSSSSSSTS STSSTSSSST
TAPLLPKAAR EKPEAPAEPP GPGPGSGAHP GGSARPDAKE EQQQQLRRKI NSRERKRMQD
LNLAMDALRE VILPYSAAHC QGAPGRKLSK IATLLLARNY ILLLGSSLQE LRRALGEGAG
PAAPRLLLAG LPLLAAAPGS VLLAPGAVGP PDALRPAKYL SLALDEPPCG QFALPGGGAG
GPGLCTCAVC KFPHLVPASL GLAAVQAQFS K
