OLIG1_MOUSE
ID OLIG1_MOUSE Reviewed; 260 AA.
AC Q9JKN5;
DT 30-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT 30-AUG-2002, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Oligodendrocyte transcription factor 1;
DE Short=Oligo1;
DE AltName: Full=Oligodendrocyte-specific bHLH transcription factor 1;
GN Name=Olig1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=Swiss Webster; TISSUE=Embryo;
RX PubMed=11091082; DOI=10.1016/s0925-4773(00)00466-4;
RA Takebayashi H., Yoshida S., Sugimori M., Kosako H., Kominami R.,
RA Nakafuku M., Nabeshima Y.;
RT "Dynamic expression of basic helix-loop-helix Olig family members:
RT implication of Olig2 in neuron and oligodendrocyte differentiation and
RT identification of a new member, Olig3.";
RL Mech. Dev. 99:143-148(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 17-260, AND DEVELOPMENTAL STAGE.
RX PubMed=10719889; DOI=10.1016/s0896-6273(00)80898-3;
RA Zhou Q., Wang S., Anderson D.J.;
RT "Identification of a novel family of oligodendrocyte lineage-specific basic
RT helix-loop-helix transcription factors.";
RL Neuron 25:331-343(2000).
RN [4]
RP INDUCTION BY SHH.
RX PubMed=10719888; DOI=10.1016/s0896-6273(00)80897-1;
RA Lu Q.R., Yuk D.-I., Alberta J.A., Zhu Z., Pawlitzky I., Chan J.A.,
RA McMahon A.P., Stiles C.D., Rowitch D.H.;
RT "Sonic hedgehog-regulated oligodendrocyte lineage genes encoding bHLH
RT proteins in the mammalian central nervous system.";
RL Neuron 25:317-329(2000).
RN [5]
RP FUNCTION.
RX PubMed=11955448; DOI=10.1016/s0092-8674(02)00678-5;
RA Lu Q.R., Sun T., Zhu Z., Ma N., Garcia M., Stiles C.D., Rowitch D.H.;
RT "Common developmental requirement for Olig function indicates a motor
RT neuron/oligodendrocyte connection.";
RL Cell 109:75-86(2002).
CC -!- FUNCTION: Promotes formation and maturation of oligodendrocytes,
CC especially within the brain. Cooperates with OLIG2 to establish the pMN
CC domain of the embryonic neural tube. {ECO:0000269|PubMed:11955448}.
CC -!- INTERACTION:
CC Q9JKN5; P41136: Id2; NbExp=5; IntAct=EBI-1213712, EBI-309167;
CC Q9JKN5; P41139: Id4; NbExp=5; IntAct=EBI-1213712, EBI-1213725;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- TISSUE SPECIFICITY: Expressed specifically in brain.
CC {ECO:0000269|PubMed:11091082}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the ventral spinal cord as early as
CC 9.5 dpc. Expression declines to undetectable levels by 10.5 dpc and
CC reappears in a narrow zone within the ventral neuroepithelium of the
CC spinal cord. In the 14.5 dpc spinal cord, expressed in the
CC oligodendrocyte progenitors of the ventral ventricular zone, but not
CC dorsal root ganglia Schwann cells. Also expressed scattered in the
CC mantle zone, likely corresponding to oligodendrocyte progenitors
CC migrating out from their site of origin. By 15.5 dpc, dispersed
CC throughout the gray matter, with little or no residual expression in
CC the ventricular zone. In the postnatal brain, present preferentially in
CC the white matter, such as corpus callosum and cerebellar medulla.
CC Expressed in the olfactory epithelium from 11.5dpc onward.
CC {ECO:0000269|PubMed:10719889}.
CC -!- INDUCTION: By SHH. {ECO:0000269|PubMed:10719888}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB18906.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB038696; BAB18906.1; ALT_INIT; mRNA.
DR EMBL; BC046316; AAH46316.1; -; mRNA.
DR EMBL; AF232928; AAF61721.1; -; Genomic_DNA.
DR CCDS; CCDS28324.1; -.
DR RefSeq; NP_058664.2; NM_016968.4.
DR AlphaFoldDB; Q9JKN5; -.
DR SMR; Q9JKN5; -.
DR BioGRID; 206153; 5.
DR IntAct; Q9JKN5; 10.
DR MINT; Q9JKN5; -.
DR STRING; 10090.ENSMUSP00000061408; -.
DR iPTMnet; Q9JKN5; -.
DR PhosphoSitePlus; Q9JKN5; -.
DR PaxDb; Q9JKN5; -.
DR PRIDE; Q9JKN5; -.
DR ProteomicsDB; 293514; -.
DR ABCD; Q9JKN5; 1 sequenced antibody.
DR Antibodypedia; 22667; 358 antibodies from 40 providers.
DR DNASU; 50914; -.
DR Ensembl; ENSMUST00000056882; ENSMUSP00000061408; ENSMUSG00000046160.
DR GeneID; 50914; -.
DR KEGG; mmu:50914; -.
DR UCSC; uc007zxf.1; mouse.
DR CTD; 116448; -.
DR MGI; MGI:1355334; Olig1.
DR VEuPathDB; HostDB:ENSMUSG00000046160; -.
DR eggNOG; KOG3898; Eukaryota.
DR GeneTree; ENSGT00940000162722; -.
DR HOGENOM; CLU_060337_0_0_1; -.
DR InParanoid; Q9JKN5; -.
DR OMA; AHCQSSP; -.
DR OrthoDB; 1205889at2759; -.
DR PhylomeDB; Q9JKN5; -.
DR TreeFam; TF322733; -.
DR BioGRID-ORCS; 50914; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Olig1; mouse.
DR PRO; PR:Q9JKN5; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q9JKN5; protein.
DR Bgee; ENSMUSG00000046160; Expressed in cranial nerve II and 112 other tissues.
DR ExpressionAtlas; Q9JKN5; baseline and differential.
DR Genevisible; Q9JKN5; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; ISS:MGI.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0048663; P:neuron fate commitment; IMP:MGI.
DR GO; GO:0014003; P:oligodendrocyte development; IMP:CACAO.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:MGI.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR032657; Olig1.
DR PANTHER; PTHR19290:SF7; PTHR19290:SF7; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..260
FT /note="Oligodendrocyte transcription factor 1"
FT /id="PRO_0000127412"
FT DOMAIN 94..153
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 42..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..57
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..104
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 260 AA; 27141 MW; 5EA8A74D9DF0D310 CRC64;
MYYAISQARV NAAPATMLRP QRPGDVQLGA SLYELVGYRQ PPISSSSSSS SSTASLLPKP
AREKAEAPLA EPRGPAPESG GARADAKEEQ QQQQLRRKIN SRERKRMQDL NLAMDALREV
ILPYSAAHCQ GAPGRKLSKI ATLLLARNYI LLLGSSLQEL RRALGDGAGP AAPRLLLAGL
PLLAAAPGSV LLAPGAVGPP ETLRPTKYLS LALDEPPCGQ FSLPAGGAGS PGLCSCAVCK
FPHLVPAGLG LAAVQAQFSK
