ID   OLIG1_RAT               Reviewed;         261 AA.
AC   Q9WUQ3;
DT   30-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2002, sequence version 2.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Oligodendrocyte transcription factor 1;
DE            Short=Oligo1;
DE   AltName: Full=Olg-1 bHLH protein;
GN   Name=Olig1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND
RP   INDUCTION BY SHH.
RC   STRAIN=Sprague-Dawley; TISSUE=Brain cortex;
RX   PubMed=10719888; DOI=10.1016/s0896-6273(00)80897-1;
RA   Lu Q.R., Yuk D.-I., Alberta J.A., Zhu Z., Pawlitzky I., Chan J.A.,
RA   McMahon A.P., Stiles C.D., Rowitch D.H.;
RT   "Sonic hedgehog-regulated oligodendrocyte lineage genes encoding bHLH
RT   proteins in the mammalian central nervous system.";
RL   Neuron 25:317-329(2000).
CC   -!- FUNCTION: Promotes formation and maturation of oligodendrocytes,
CC       especially within the brain. Cooperates with OLIG2 to establish the pMN
CC       domain of the embryonic neural tube (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC   -!- TISSUE SPECIFICITY: Expressed specifically in the brain, including the
CC       corpus callosum, hippocampal and cerebral white matter. Also detected
CC       in cells scattered in gray matter, most probably in oligodendrocytes.
CC       {ECO:0000269|PubMed:10719888}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in oligodendrocytes of the postnatal
CC       optical nerve up to day 30, then the number of expressing cells
CC       decreases. {ECO:0000269|PubMed:10719888}.
CC   -!- INDUCTION: By SHH. {ECO:0000269|PubMed:10719888}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD34029.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF151367; AAD34029.1; ALT_INIT; mRNA.
DR   RefSeq; NP_068538.2; NM_021770.4.
DR   AlphaFoldDB; Q9WUQ3; -.
DR   SMR; Q9WUQ3; -.
DR   STRING; 10116.ENSRNOP00000002827; -.
DR   jPOST; Q9WUQ3; -.
DR   PaxDb; Q9WUQ3; -.
DR   PRIDE; Q9WUQ3; -.
DR   ABCD; Q9WUQ3; 1 sequenced antibody.
DR   Ensembl; ENSRNOT00000002827; ENSRNOP00000002827; ENSRNOG00000028648.
DR   GeneID; 60394; -.
DR   KEGG; rno:60394; -.
DR   UCSC; RGD:621129; rat.
DR   CTD; 116448; -.
DR   RGD; 621129; Olig1.
DR   eggNOG; KOG3898; Eukaryota.
DR   GeneTree; ENSGT00940000162722; -.
DR   HOGENOM; CLU_060337_0_0_1; -.
DR   InParanoid; Q9WUQ3; -.
DR   OrthoDB; 1205889at2759; -.
DR   PhylomeDB; Q9WUQ3; -.
DR   TreeFam; TF322733; -.
DR   PRO; PR:Q9WUQ3; -.
DR   Proteomes; UP000002494; Chromosome 11.
DR   Genevisible; Q9WUQ3; RN.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR   GO; GO:0048663; P:neuron fate commitment; ISO:RGD.
DR   GO; GO:0014003; P:oligodendrocyte development; ISO:RGD.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR032657; Olig1.
DR   PANTHER; PTHR19290:SF7; PTHR19290:SF7; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..261
FT                   /note="Oligodendrocyte transcription factor 1"
FT                   /id="PRO_0000127413"
FT   DOMAIN          95..154
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          41..105
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..58
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        83..105
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   261 AA;  27239 MW;  C0CE520275550322 CRC64;
     MYYAVSQARV NAAPATMLRP QRPGDVQLGA SLYELVGYRQ PPISSSSSTS SSSTASLLPK
     PAREKPEAPL AEPRGPAPES GGARADAKEE QQQQQLRRKI NSRERKRMQD LNLAMDALRE
     VILPYSAAHC QGAPGRKLSK IATLLLARNY ILLLGSSLQE LRRALGDGAG PAAPRLLLAG
     LPLLAAAPGS VLLAPGAVGP PETLRPTKYL SLALDEPPCG QFALPAGGAG SPGLCSCAVC
     KFPHLVPAGL GLAAVQAQFS K