ID   OLIG2_CHICK             Reviewed;         298 AA.
AC   Q90XB3; Q90XC8;
DT   30-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Oligodendrocyte transcription factor 2;
DE            Short=Oligo2;
GN   Name=OLIG2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11567617; DOI=10.1016/s0896-6273(01)00414-7;
RA   Zhou Q., Choi G., Anderson D.J.;
RT   "The bHLH transcription factor Olig2 promotes oligodendrocyte
RT   differentiation in collaboration with Nkx2.2.";
RL   Neuron 31:791-807(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 99-161.
RX   PubMed=11567616; DOI=10.1016/s0896-6273(01)00407-x;
RA   Novitch B.G., Chen A.I., Jessell T.M.;
RT   "Coordinate regulation of motor neuron subtype identity and pan-neuronal
RT   properties by the bHLH repressor Olig2.";
RL   Neuron 31:773-789(2001).
CC   -!- FUNCTION: Required for oligodendrocyte and motor neuron specification
CC       in the spinal cord. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR   EMBL; AF411041; AAL11883.1; -; mRNA.
DR   EMBL; AF405699; AAL02428.1; -; mRNA.
DR   RefSeq; NP_001026697.1; NM_001031526.1.
DR   AlphaFoldDB; Q90XB3; -.
DR   SMR; Q90XB3; -.
DR   STRING; 9031.ENSGALP00000043426; -.
DR   Ensembl; ENSGALT00000049196; ENSGALP00000047462; ENSGALG00000031010.
DR   GeneID; 428612; -.
DR   KEGG; gga:428612; -.
DR   CTD; 10215; -.
DR   VEuPathDB; HostDB:geneid_428612; -.
DR   eggNOG; KOG3898; Eukaryota.
DR   GeneTree; ENSGT00940000161651; -.
DR   HOGENOM; CLU_065376_1_0_1; -.
DR   InParanoid; Q90XB3; -.
DR   OMA; PVHHPIL; -.
DR   OrthoDB; 1290623at2759; -.
DR   PhylomeDB; Q90XB3; -.
DR   PRO; PR:Q90XB3; -.
DR   Proteomes; UP000000539; Chromosome 1.
DR   Bgee; ENSGALG00000031010; Expressed in cerebellum.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IDA:AgBase.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0071837; F:HMG box domain binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0042552; P:myelination; IEA:Ensembl.
DR   GO; GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR   GO; GO:0048663; P:neuron fate commitment; IEA:Ensembl.
DR   GO; GO:0048714; P:positive regulation of oligodendrocyte differentiation; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0021522; P:spinal cord motor neuron differentiation; IEA:Ensembl.
DR   GO; GO:0021530; P:spinal cord oligodendrocyte cell fate specification; IEA:Ensembl.
DR   GO; GO:0021794; P:thalamus development; IEA:Ensembl.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR032658; Olig2.
DR   PANTHER; PTHR19290:SF32; PTHR19290:SF32; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..298
FT                   /note="Oligodendrocyte transcription factor 2"
FT                   /id="PRO_0000127416"
FT   DOMAIN          106..160
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          1..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          79..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..56
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        79..93
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   298 AA;  30319 MW;  5790A79F2764F5D8 CRC64;
     MDSDASLVSS RPSSPEPDEL FLAGRNKGGG GGGGGGGGFT GGTVSSSTQS DSPPELSAEL
     RSAMSAAGVV VVDKLGFKSS SSSASSASSA SSKKDKKQMT EPELQQLRLK INSRERKRMH
     DLNIAMDGLR EVMPYAHGPS VRKLSKIATL LLARNYILML TNSLEEMKRL VSEIYGGHHA
     AFHPAACPAG MGAHSAPLPA HPGHPASHPA HHPILPPAAV SSASLPGSGL SAVGSIRPPH
     GLLKSPSAAA AAPGLGGGFQ HWGGMPCPCS MCQVAAPPHH HVSAMGGAAL PRLASDAK