OLIG3_HUMAN
ID OLIG3_HUMAN Reviewed; 272 AA.
AC Q7RTU3; Q8N8Q0;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 31-AUG-2004, sequence version 2.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Oligodendrocyte transcription factor 3;
DE Short=Oligo3;
DE AltName: Full=Class B basic helix-loop-helix protein 7;
DE Short=bHLHb7;
DE AltName: Full=Class E basic helix-loop-helix protein 20;
DE Short=bHLHe20;
GN Name=OLIG3; Synonyms=BHLHB7, BHLHE20;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14516699; DOI=10.1016/s0925-4773(03)00130-8;
RA McLellan A.S., Langlands K., Kealey T.;
RT "Exhaustive identification of human class II basic helix-loop-helix
RT proteins by virtual library screening.";
RL Mech. Dev. 119:S285-S291(2002).
CC -!- FUNCTION: May determine the distinct specification program of class A
CC neurons in the dorsal part of the spinal cord and suppress
CC specification of class B neurons.
CC -!- INTERACTION:
CC Q7RTU3; Q9BXS5: AP1M1; NbExp=3; IntAct=EBI-10225049, EBI-541426;
CC Q7RTU3; Q03989: ARID5A; NbExp=4; IntAct=EBI-10225049, EBI-948603;
CC Q7RTU3; Q86V38: ATN1; NbExp=3; IntAct=EBI-10225049, EBI-11954292;
CC Q7RTU3; Q13895: BYSL; NbExp=5; IntAct=EBI-10225049, EBI-358049;
CC Q7RTU3; A2RRN7: CADPS; NbExp=3; IntAct=EBI-10225049, EBI-10179719;
CC Q7RTU3; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-10225049, EBI-3866279;
CC Q7RTU3; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-10225049, EBI-3867333;
CC Q7RTU3; G5E9A7: DMWD; NbExp=3; IntAct=EBI-10225049, EBI-10976677;
CC Q7RTU3; Q9NP66: HMG20A; NbExp=3; IntAct=EBI-10225049, EBI-740641;
CC Q7RTU3; O43790: KRT86; NbExp=3; IntAct=EBI-10225049, EBI-9996498;
CC Q7RTU3; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-10225049, EBI-11959885;
CC Q7RTU3; P60410: KRTAP10-8; NbExp=5; IntAct=EBI-10225049, EBI-10171774;
CC Q7RTU3; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-10225049, EBI-1052037;
CC Q7RTU3; Q3LHN2: KRTAP19-2; NbExp=3; IntAct=EBI-10225049, EBI-12196745;
CC Q7RTU3; Q3LI72: KRTAP19-5; NbExp=3; IntAct=EBI-10225049, EBI-1048945;
CC Q7RTU3; Q9BYR7: KRTAP3-2; NbExp=3; IntAct=EBI-10225049, EBI-751260;
CC Q7RTU3; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-10225049, EBI-3957694;
CC Q7RTU3; Q3LI64: KRTAP6-1; NbExp=3; IntAct=EBI-10225049, EBI-12111050;
CC Q7RTU3; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-10225049, EBI-11962084;
CC Q7RTU3; Q9BYQ0: KRTAP9-8; NbExp=3; IntAct=EBI-10225049, EBI-11958364;
CC Q7RTU3; Q99750: MDFI; NbExp=6; IntAct=EBI-10225049, EBI-724076;
CC Q7RTU3; P55081: MFAP1; NbExp=3; IntAct=EBI-10225049, EBI-1048159;
CC Q7RTU3; Q9UPG8: PLAGL2; NbExp=3; IntAct=EBI-10225049, EBI-2876622;
CC Q7RTU3; O75360: PROP1; NbExp=3; IntAct=EBI-10225049, EBI-9027467;
CC Q7RTU3; Q01196-8: RUNX1; NbExp=3; IntAct=EBI-10225049, EBI-12001422;
CC Q7RTU3; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-10225049, EBI-5235340;
CC Q7RTU3; Q08117: TLE5; NbExp=3; IntAct=EBI-10225049, EBI-717810;
CC Q7RTU3; Q08117-2: TLE5; NbExp=5; IntAct=EBI-10225049, EBI-11741437;
CC Q7RTU3; Q13077: TRAF1; NbExp=6; IntAct=EBI-10225049, EBI-359224;
CC Q7RTU3; Q9NZC7-5: WWOX; NbExp=3; IntAct=EBI-10225049, EBI-12040603;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- SEQUENCE CAUTION:
CC Sequence=DAA00303.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK096362; BAC04768.1; -; mRNA.
DR EMBL; AL023580; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC051352; AAH51352.1; -; mRNA.
DR EMBL; BK000141; DAA00303.1; ALT_INIT; Genomic_DNA.
DR CCDS; CCDS5186.1; -.
DR RefSeq; NP_786923.1; NM_175747.2.
DR AlphaFoldDB; Q7RTU3; -.
DR SMR; Q7RTU3; -.
DR BioGRID; 127951; 32.
DR IntAct; Q7RTU3; 29.
DR STRING; 9606.ENSP00000356708; -.
DR GlyGen; Q7RTU3; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q7RTU3; -.
DR PhosphoSitePlus; Q7RTU3; -.
DR BioMuta; OLIG3; -.
DR DMDM; 51701664; -.
DR MassIVE; Q7RTU3; -.
DR PaxDb; Q7RTU3; -.
DR PeptideAtlas; Q7RTU3; -.
DR PRIDE; Q7RTU3; -.
DR ProteomicsDB; 68906; -.
DR Antibodypedia; 19782; 197 antibodies from 30 providers.
DR DNASU; 167826; -.
DR Ensembl; ENST00000367734.4; ENSP00000356708.2; ENSG00000177468.7.
DR GeneID; 167826; -.
DR KEGG; hsa:167826; -.
DR MANE-Select; ENST00000367734.4; ENSP00000356708.2; NM_175747.2; NP_786923.1.
DR UCSC; uc003qhp.2; human.
DR CTD; 167826; -.
DR DisGeNET; 167826; -.
DR GeneCards; OLIG3; -.
DR HGNC; HGNC:18003; OLIG3.
DR HPA; ENSG00000177468; Not detected.
DR MIM; 609323; gene.
DR neXtProt; NX_Q7RTU3; -.
DR OpenTargets; ENSG00000177468; -.
DR PharmGKB; PA134945348; -.
DR VEuPathDB; HostDB:ENSG00000177468; -.
DR eggNOG; KOG3898; Eukaryota.
DR GeneTree; ENSGT00940000160850; -.
DR HOGENOM; CLU_065376_1_0_1; -.
DR InParanoid; Q7RTU3; -.
DR OMA; PHALMKG; -.
DR OrthoDB; 1290623at2759; -.
DR PhylomeDB; Q7RTU3; -.
DR TreeFam; TF322733; -.
DR PathwayCommons; Q7RTU3; -.
DR SignaLink; Q7RTU3; -.
DR BioGRID-ORCS; 167826; 10 hits in 1083 CRISPR screens.
DR ChiTaRS; OLIG3; human.
DR GenomeRNAi; 167826; -.
DR Pharos; Q7RTU3; Tbio.
DR PRO; PR:Q7RTU3; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q7RTU3; protein.
DR Bgee; ENSG00000177468; Expressed in islet of Langerhans and 8 other tissues.
DR Genevisible; Q7RTU3; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0021520; P:spinal cord motor neuron cell fate specification; IEA:Ensembl.
DR GO; GO:0097476; P:spinal cord motor neuron migration; IEA:Ensembl.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR032659; Olig3.
DR PANTHER; PTHR19290:SF96; PTHR19290:SF96; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Coiled coil; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..272
FT /note="Oligodendrocyte transcription factor 3"
FT /id="PRO_0000127417"
FT DOMAIN 83..137
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 68..89
FT /evidence="ECO:0000255"
SQ SEQUENCE 272 AA; 29358 MW; 9ED98EF52F34D9A5 CRC64;
MNSDSSSVSS RASSPDMDEM YLRDHHHRHH HHQESRLNSV SSTQGDMMQK MPGESLSRAG
AKAAGESSKY KIKKQLSEQD LQQLRLKING RERKRMHDLN LAMDGLREVM PYAHGPSVRK
LSKIATLLLA RNYILMLTSS LEEMKRLVGE IYGGHHSAFH CGTVGHSAGH PAHAANSVHP
VHPILGGALS SGNASSPLSA ASLPAIGTIR PPHSLLKAPS TPPALQLGSG FQHWAGLPCP
CTICQMPPPP HLSALSTANM ARLSAESKDL LK
