OLIG3_MOUSE
ID OLIG3_MOUSE Reviewed; 273 AA.
AC Q6PFG8; Q9EQW5;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Oligodendrocyte transcription factor 3;
DE Short=Oligo3;
DE AltName: Full=Class B basic helix-loop-helix protein 7;
DE Short=bHLHb7;
DE AltName: Full=Oligodendrocyte-specific bHLH transcription factor 3;
GN Name=Olig3; Synonyms=Bhlhb7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND SUBCELLULAR LOCATION.
RC STRAIN=Swiss Webster; TISSUE=Embryo;
RX PubMed=11091082; DOI=10.1016/s0925-4773(00)00466-4;
RA Takebayashi H., Yoshida S., Sugimori M., Kosako H., Kominami R.,
RA Nakafuku M., Nabeshima Y.;
RT "Dynamic expression of basic helix-loop-helix Olig family members:
RT implication of Olig2 in neuron and oligodendrocyte differentiation and
RT identification of a new member, Olig3.";
RL Mech. Dev. 99:143-148(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP DEVELOPMENTAL STAGE, AND SUBCELLULAR LOCATION.
RX PubMed=11960707; DOI=10.1016/s0925-4773(02)00021-7;
RA Takebayashi H., Ohtsuki T., Uchida T., Kawamoto S., Okubo K., Ikenaka K.,
RA Takeichi M., Chisaka O., Nabeshima Y.;
RT "Non-overlapping expression of Olig3 and Olig2 in the embryonic neural
RT tube.";
RL Mech. Dev. 113:169-174(2002).
RN [4]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=15769945; DOI=10.1101/gad.326105;
RA Mueller T., Anlag K., Wildner H., Britsch S., Treier M., Birchmeier C.;
RT "The bHLH factor Olig3 coordinates the specification of dorsal neurons in
RT the spinal cord.";
RL Genes Dev. 19:733-743(2005).
CC -!- FUNCTION: May determine the distinct specification program of class A
CC neurons in the dorsal part of the spinal cord and suppress
CC specification of class B neurons. {ECO:0000269|PubMed:15769945}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981,
CC ECO:0000269|PubMed:11091082, ECO:0000269|PubMed:11960707}.
CC -!- TISSUE SPECIFICITY: Weakly expressed, mainly in non-neural tissues.
CC {ECO:0000269|PubMed:15489334}.
CC -!- DEVELOPMENTAL STAGE: Restricted to the CNS. At 9.25 and 10.5 dpc,
CC specifically expressed in the dorsal neural tube from the
CC midbrain/hindbrain boundary to the spinal cord. At 10.5 dpc, expressed
CC continuously from the upper rhombic lip to the tail. From 10.5 to 12.5
CC dpc, located in the most dorsal aspect of the spinal cord, excluding
CC the roof plate, mainly in proliferating progenitor cells; quickly down-
CC regulated in postmitotic neurons. At 11.5 dpc, 3 ventral expression
CC clusters, corresponding to p3, p2 and p0 domains, transiently appear on
CC the lateral margin of the subventricular zone, in addition to dorsal
CC expression. At 14.5 dpc, weakly expressed in cells scattered in the
CC mantle zone. Expression declines after 15.5 dpc. In the 11.5 dpc
CC forebrain, expressed in the ventricular zone of the dorsal thalamus. In
CC the 11.5 to 14.5 dpc hindbrain, dorsally expressed in the upper and
CC lower rhombic lip, in the cerebellar neuroepithelium.
CC {ECO:0000269|PubMed:11960707, ECO:0000269|PubMed:15769945}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB18908.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB038698; BAB18908.1; ALT_INIT; mRNA.
DR EMBL; BC057564; AAH57564.1; -; mRNA.
DR CCDS; CCDS35855.1; -.
DR RefSeq; NP_443734.2; NM_053008.3.
DR AlphaFoldDB; Q6PFG8; -.
DR SMR; Q6PFG8; -.
DR STRING; 10090.ENSMUSP00000057106; -.
DR PhosphoSitePlus; Q6PFG8; -.
DR PaxDb; Q6PFG8; -.
DR PRIDE; Q6PFG8; -.
DR ProteomicsDB; 289986; -.
DR Antibodypedia; 19782; 197 antibodies from 30 providers.
DR DNASU; 94222; -.
DR Ensembl; ENSMUST00000053225; ENSMUSP00000057106; ENSMUSG00000045591.
DR GeneID; 94222; -.
DR KEGG; mmu:94222; -.
DR UCSC; uc007ene.1; mouse.
DR CTD; 167826; -.
DR MGI; MGI:2149955; Olig3.
DR VEuPathDB; HostDB:ENSMUSG00000045591; -.
DR eggNOG; KOG3898; Eukaryota.
DR GeneTree; ENSGT00940000160850; -.
DR HOGENOM; CLU_065376_1_0_1; -.
DR InParanoid; Q6PFG8; -.
DR OMA; PHALMKG; -.
DR OrthoDB; 1290623at2759; -.
DR PhylomeDB; Q6PFG8; -.
DR TreeFam; TF322733; -.
DR BioGRID-ORCS; 94222; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q6PFG8; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q6PFG8; protein.
DR Bgee; ENSMUSG00000045591; Expressed in ureteric bud trunk and 41 other tissues.
DR Genevisible; Q6PFG8; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; IMP:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0021520; P:spinal cord motor neuron cell fate specification; IMP:MGI.
DR GO; GO:0021522; P:spinal cord motor neuron differentiation; IMP:MGI.
DR GO; GO:0097476; P:spinal cord motor neuron migration; IMP:MGI.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR032659; Olig3.
DR PANTHER; PTHR19290:SF96; PTHR19290:SF96; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..273
FT /note="Oligodendrocyte transcription factor 3"
FT /id="PRO_0000127418"
FT DOMAIN 84..138
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 1..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 69..90
FT /evidence="ECO:0000255"
SQ SEQUENCE 273 AA; 29507 MW; 5795CF3FC23121DD CRC64;
MNSDSSSVSS RASSPDMDEM YLRDHHHRHH HHHQESRLNS VSSTQGDMVQ KMPGESLSRA
GAKAAGESSK YKIKKQLSEQ DLQQLRLKIN GRERKRMHDL NLAMDGLREV MPYAHGPSVR
KLSKIATLLL ARNYILMLTS SLEEMKRLVG EIYGGHHSAF HCGTVGHSAG HPAHAANAVH
PVHPILGGAL SSGNASSPLS ATSLPTIGTI RPPHSLLKAP STPPALQLGS GFQHWAGLPC
PCTICQMPPP PHLSALSTAN MARLSAESKD LLK
