OLM2A_MOUSE
ID OLM2A_MOUSE Reviewed; 681 AA.
AC Q8BHP7;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Olfactomedin-like protein 2A;
DE AltName: Full=Photomedin-1;
DE Flags: Precursor;
GN Name=Olfml2a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Urinary bladder;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP PROTEIN SEQUENCE OF 33-42 AND 301-310, SUBUNIT, CLEAVAGE SITE,
RP GLYCOSYLATION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=15836428; DOI=10.1042/bj20050120;
RA Furutani Y., Manabe R., Tsutsui K., Yamada T., Sugimoto N., Fukuda S.,
RA Kawai J., Sugiura N., Kimata K., Hayashizaki Y., Sekiguchi K.;
RT "Identification and characterization of photomedins: novel olfactomedin-
RT domain-containing proteins with chondroitin sulphate-E-binding activity.";
RL Biochem. J. 389:675-684(2005).
CC -!- SUBUNIT: Homodimer. Binds to heparin and chondroitin sulfate E.
CC {ECO:0000269|PubMed:15836428}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15836428}.
CC -!- TISSUE SPECIFICITY: Expressed in lung, eye, testis, uterus, ovary, and
CC to a lesser extent in heart, skeletal muscle, mammary gland, skin and
CC prostate. Within the eye, mainly present in photoreceptor layers (at
CC protein level). {ECO:0000269|PubMed:15836428}.
CC -!- PTM: Seems to be cleaved at Lys-301 after secretion.
CC {ECO:0000269|PubMed:15836428}.
CC -!- PTM: O-glycosylated but not N-glycosylated.
CC {ECO:0000269|PubMed:15836428}.
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DR EMBL; AK035313; BAC29029.1; -; mRNA.
DR EMBL; AL844588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL935155; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS16013.1; -.
DR RefSeq; NP_766442.1; NM_172854.2.
DR AlphaFoldDB; Q8BHP7; -.
DR SMR; Q8BHP7; -.
DR BioGRID; 232309; 1.
DR STRING; 10090.ENSMUSP00000058761; -.
DR iPTMnet; Q8BHP7; -.
DR PhosphoSitePlus; Q8BHP7; -.
DR MaxQB; Q8BHP7; -.
DR PaxDb; Q8BHP7; -.
DR PRIDE; Q8BHP7; -.
DR ProteomicsDB; 289987; -.
DR Antibodypedia; 16348; 161 antibodies from 24 providers.
DR Ensembl; ENSMUST00000057279; ENSMUSP00000058761; ENSMUSG00000046618.
DR GeneID; 241327; -.
DR KEGG; mmu:241327; -.
DR UCSC; uc008jnv.1; mouse.
DR CTD; 169611; -.
DR MGI; MGI:2444741; Olfml2a.
DR VEuPathDB; HostDB:ENSMUSG00000046618; -.
DR eggNOG; KOG3545; Eukaryota.
DR GeneTree; ENSGT00940000157194; -.
DR HOGENOM; CLU_024107_0_0_1; -.
DR InParanoid; Q8BHP7; -.
DR OMA; PQLPFRN; -.
DR OrthoDB; 311650at2759; -.
DR PhylomeDB; Q8BHP7; -.
DR TreeFam; TF351220; -.
DR BioGRID-ORCS; 241327; 4 hits in 73 CRISPR screens.
DR ChiTaRS; Olfml2a; mouse.
DR PRO; PR:Q8BHP7; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8BHP7; protein.
DR Bgee; ENSMUSG00000046618; Expressed in lumbar dorsal root ganglion and 88 other tissues.
DR ExpressionAtlas; Q8BHP7; baseline and differential.
DR Genevisible; Q8BHP7; MM.
DR GO; GO:0031012; C:extracellular matrix; IDA:MGI.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0050840; F:extracellular matrix binding; IDA:MGI.
DR GO; GO:0042802; F:identical protein binding; IPI:MGI.
DR GO; GO:0030198; P:extracellular matrix organization; IDA:MGI.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR003112; Olfac-like_dom.
DR InterPro; IPR031231; OLFML2A.
DR PANTHER; PTHR23192:SF29; PTHR23192:SF29; 1.
DR Pfam; PF02191; OLF; 1.
DR SMART; SM00284; OLF; 1.
DR PROSITE; PS51132; OLF; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Direct protein sequencing; Disulfide bond; Glycoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..32
FT /evidence="ECO:0000269|PubMed:15836428"
FT CHAIN 33..681
FT /note="Olfactomedin-like protein 2A"
FT /id="PRO_0000311429"
FT DOMAIN 423..681
FT /note="Olfactomedin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00446"
FT REGION 216..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 305..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..355
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..441
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 300..301
FT /note="Cleavage"
FT DISULFID 424..611
FT /evidence="ECO:0000305"
SQ SEQUENCE 681 AA; 76547 MW; 89B22A48BECC66BD CRC64;
MEAAAVLPRY LQLRLLLVLL LLVLLRAGPV WPDSKVFSDL DQVRMTSEGS DCRCKCIMRP
LSKDACSRVR SGRARVEDFY TVETVSSGAD CRCSCTAPPS SLNPCENEWK MEKLKKQAPE
LLKLQSMVDL LEGALYSMDL MKVHAYIQKV ASQMNTLEES IKANLSLENK VVKDSVHHLS
EQLKSYENQS AIMMSIKKEL SSLGLQLLQR DAAAVPATAP ASSPDSKAQD TAGGQGRDLN
KYGSIQKSFS DKGLAKPPKE KLLKVEKLRK ESIKGRIPQP TARPRALAQQ QAVIRGFTYY
KAGRQEARQE ARQEAPKAAA DSTLKGTSWL EKLPPKIEAK LPEPNSAKHD DVRLQASEGG
NLTPDITTTT TSTSSSTTTT TGTTSTTSTT STTSTTTPSP ITTPWPTEPP LHPEVPSQGR
EDSCEGTLRA VDPPVKHHSY GRHEGAWMKD PAALDDRIYV TNYYYGNSLV EFRNLENFKQ
GRWSNMYKLP YNWIGTGHVV YQGAFYYNRA FTKNIIKYDL RQRFVASWAL LPDVVYEDTT
PWKWRGHSDI DFAVDESGLW VIYPAVDEHD ETQHEVIVLS RLDPADLSVH RETTWKTRLR
RNSYGNCFLV CGILYTVDTY NQHEGQVAYA FDTHTGTDAH PQLPFLNEYS YTTQVDYNPK
ERVLYAWDNG HQLTYTLHFV V
