ID   OLM2A_PIG               Reviewed;         650 AA.
AC   A2BD09; F1SKR6;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   29-OCT-2014, sequence version 3.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Olfactomedin-like protein 2A;
DE   Flags: Precursor;
GN   Name=OLFML2A;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Large white X Landrace X Duroc;
RX   PubMed=17416745; DOI=10.1101/gr.6085507;
RA   Mikawa S., Morozumi T., Shimanuki S., Hayashi T., Uenishi H., Domukai M.,
RA   Okumura N., Awata T.;
RT   "Fine mapping of a swine quantitative trait locus for number of vertebrae
RT   and analysis of an orphan nuclear receptor, germ cell nuclear factor
RT   (NR6A1).";
RL   Genome Res. 17:586-593(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Homodimer. Binds to heparin and chondroitin sulfate E.
CC       {ECO:0000250|UniProtKB:Q8BHP7}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8BHP7}.
CC   -!- PTM: O-glycosylated but not N-glycosylated.
CC       {ECO:0000250|UniProtKB:Q8BHP7}.
CC   -!- PTM: May be cleaved at Lys-301 after secretion.
CC       {ECO:0000250|UniProtKB:Q8BHP7}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAF45333.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AP009124; BAF45333.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CU468031; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A2BD09; -.
DR   SMR; A2BD09; -.
DR   STRING; 9823.ENSSSCP00000005990; -.
DR   PaxDb; A2BD09; -.
DR   PRIDE; A2BD09; -.
DR   eggNOG; KOG3545; Eukaryota.
DR   InParanoid; A2BD09; -.
DR   TreeFam; TF351220; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   InterPro; IPR003112; Olfac-like_dom.
DR   InterPro; IPR031231; OLFML2A.
DR   PANTHER; PTHR23192:SF29; PTHR23192:SF29; 1.
DR   Pfam; PF02191; OLF; 1.
DR   SMART; SM00284; OLF; 1.
DR   PROSITE; PS51132; OLF; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Disulfide bond; Glycoprotein; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000250|UniProtKB:Q8BHP7"
FT   CHAIN           33..650
FT                   /note="Olfactomedin-like protein 2A"
FT                   /id="PRO_0000311430"
FT   DOMAIN          393..650
FT                   /note="Olfactomedin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00446"
FT   REGION          214..289
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          318..406
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          163..188
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        253..276
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        334..348
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        363..386
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            300..301
FT                   /note="Cleavage"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BHP7"
FT   DISULFID        394..580
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00446"
FT   CONFLICT        475
FT                   /note="Missing (in Ref. 1; BAF45333)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   650 AA;  72527 MW;  0A528D7E4547AB93 CRC64;
     MTAAAVPLRP GPGPLPLLLL PLLLLRAGPV RADSKVFGDV DQVRMTSEGS DCRCKCIMRP
     LSKDACSRVR SGRARVEDFY TVETVSSGTD CRCSCTAPPS SLNPCENEWK MEKLKKQAPE
     LLKLQSMVDL LEGTLYSMDL MKVHAYVHKL ASQMNTLEES IKANLSRENE VVRESMRHFS
     EQLKHYENHS AIMMSIKKEL SSLGLQLLQK DAASVPGAPP ATGPGSKAQD TAGGKGKDSN
     KHGSVQKTFV DKGLPRPPKE KLLKAEKLKK EGGKARFPQP TAKPRALAQQ QAVIRGITYY
     KAGRKEMTEA MADNALKGTS WLEQLPPRVE GRLPEPNSAE RDEAGGPRAS EAADLAPGTP
     ASGPTLTPTP TASPLPTEPP SRPEVPSPGR EASCEGTLRA VDPPVRHHSY GRHEGAWMKD
     PAAKDDKIYV TNYYYGNSLV EFRNLENFKQ GRWSNMYKLP YNWIGTGHVV YQGAFYNRAF
     TKNIIKYDLR QRFVASWALL PDVVYEDTTP WKWRGHSDID FAVDESGLWV IYPAADDRDE
     AQPEVIVLSR LDPGDLSVHR ETTWKTRLRR NSYGNCFLVC GILYAVDTYN QREGHVAYAF
     DTHTGADARL QLPFLNEHAY TTQIDYNPKE RVLYAWDNGH QLTYTLHFVV