OLM2B_HUMAN
ID OLM2B_HUMAN Reviewed; 750 AA.
AC Q68BL8; B7ZA39; Q5VU96; Q6NX46; Q86X11; Q9Y3X6;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 2.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Olfactomedin-like protein 2B;
DE AltName: Full=Photomedin-2;
DE Flags: Precursor;
GN Name=OLFML2B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT ARG-470.
RC TISSUE=Retina;
RA Furutani Y., Manabe R., Tsutsui K., Yamada T., Sugimoto N., Kawai J.,
RA Hayashizaki Y., Sekiguchi K.;
RT "Photomedin-1 and -2, novel extracellular glycoproteins with olfactomedin
RT domain, isolated from RIKEN full-length mouse cDNA clones by computational
RT screening.";
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ARG-470.
RC TISSUE=Endometrium, and Uterus;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=PNS, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Homodimer. Binds to heparin and chondroitin sulfate E (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q68BL8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q68BL8-2; Sequence=VSP_029564;
CC -!- PTM: O-glycosylated and N-glycosylated. {ECO:0000250}.
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DR EMBL; AB119054; BAD38863.1; -; mRNA.
DR EMBL; AK316154; BAH14525.1; -; mRNA.
DR EMBL; BX648975; CAI45982.1; -; mRNA.
DR EMBL; AL050137; CAB43286.1; -; mRNA.
DR EMBL; AL391825; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL590408; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC047472; AAH47472.1; -; mRNA.
DR EMBL; BC067274; AAH67274.1; -; mRNA.
DR CCDS; CCDS1236.1; -. [Q68BL8-1]
DR PIR; T08771; T08771.
DR RefSeq; NP_001284642.1; NM_001297713.1.
DR RefSeq; NP_001334629.1; NM_001347700.1.
DR RefSeq; NP_056256.1; NM_015441.2. [Q68BL8-1]
DR AlphaFoldDB; Q68BL8; -.
DR SMR; Q68BL8; -.
DR BioGRID; 117410; 16.
DR IntAct; Q68BL8; 1.
DR STRING; 9606.ENSP00000356917; -.
DR GlyGen; Q68BL8; 6 sites, 2 O-linked glycans (3 sites).
DR iPTMnet; Q68BL8; -.
DR PhosphoSitePlus; Q68BL8; -.
DR BioMuta; OLFML2B; -.
DR DMDM; 160418997; -.
DR EPD; Q68BL8; -.
DR MassIVE; Q68BL8; -.
DR MaxQB; Q68BL8; -.
DR PaxDb; Q68BL8; -.
DR PeptideAtlas; Q68BL8; -.
DR PRIDE; Q68BL8; -.
DR ProteomicsDB; 65999; -. [Q68BL8-1]
DR ProteomicsDB; 66000; -. [Q68BL8-2]
DR TopDownProteomics; Q68BL8-1; -. [Q68BL8-1]
DR Antibodypedia; 34317; 150 antibodies from 20 providers.
DR DNASU; 25903; -.
DR Ensembl; ENST00000294794.8; ENSP00000294794.3; ENSG00000162745.11. [Q68BL8-1]
DR Ensembl; ENST00000367938.1; ENSP00000356915.1; ENSG00000162745.11. [Q68BL8-2]
DR GeneID; 25903; -.
DR KEGG; hsa:25903; -.
DR MANE-Select; ENST00000294794.8; ENSP00000294794.3; NM_015441.3; NP_056256.1.
DR UCSC; uc001gbt.4; human. [Q68BL8-1]
DR CTD; 25903; -.
DR DisGeNET; 25903; -.
DR GeneCards; OLFML2B; -.
DR HGNC; HGNC:24558; OLFML2B.
DR HPA; ENSG00000162745; Tissue enhanced (gallbladder).
DR neXtProt; NX_Q68BL8; -.
DR OpenTargets; ENSG00000162745; -.
DR PharmGKB; PA134990758; -.
DR VEuPathDB; HostDB:ENSG00000162745; -.
DR eggNOG; KOG3545; Eukaryota.
DR GeneTree; ENSGT00940000157757; -.
DR HOGENOM; CLU_024107_0_0_1; -.
DR InParanoid; Q68BL8; -.
DR OMA; FFEYHEF; -.
DR OrthoDB; 311650at2759; -.
DR PhylomeDB; Q68BL8; -.
DR TreeFam; TF351220; -.
DR PathwayCommons; Q68BL8; -.
DR SignaLink; Q68BL8; -.
DR BioGRID-ORCS; 25903; 9 hits in 1062 CRISPR screens.
DR ChiTaRS; OLFML2B; human.
DR GenomeRNAi; 25903; -.
DR Pharos; Q68BL8; Tbio.
DR PRO; PR:Q68BL8; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q68BL8; protein.
DR Bgee; ENSG00000162745; Expressed in decidua and 162 other tissues.
DR ExpressionAtlas; Q68BL8; baseline and differential.
DR Genevisible; Q68BL8; HS.
DR GO; GO:0031012; C:extracellular matrix; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0050840; F:extracellular matrix binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR003112; Olfac-like_dom.
DR InterPro; IPR031233; OLFML2B.
DR PANTHER; PTHR23192:SF37; PTHR23192:SF37; 1.
DR Pfam; PF02191; OLF; 1.
DR SMART; SM00284; OLF; 1.
DR PROSITE; PS51132; OLF; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Disulfide bond; Glycoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000250"
FT CHAIN 23..750
FT /note="Olfactomedin-like protein 2B"
FT /id="PRO_0000311426"
FT DOMAIN 493..750
FT /note="Olfactomedin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00446"
FT REGION 346..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 40..68
FT /evidence="ECO:0000255"
FT COILED 179..213
FT /evidence="ECO:0000255"
FT COMPBIAS 346..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 187
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 213
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 695
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 494..680
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00446"
FT VAR_SEQ 1..517
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029564"
FT VARIANT 10
FT /note="Y -> C (in dbSNP:rs12130792)"
FT /id="VAR_037248"
FT VARIANT 470
FT /note="W -> R (in dbSNP:rs2499836)"
FT /evidence="ECO:0000269|PubMed:17974005, ECO:0000269|Ref.1"
FT /id="VAR_037249"
SQ SEQUENCE 750 AA; 83999 MW; 85014757EDC8C3D0 CRC64;
MAKPRLLVLY FALIVVPAWV SSIVLTGTSE PPDAQTVAPA EDETLQNEAD NQENVLSQLL
GDYDKVKAMS EGSDCQCKCV VRPLGRDACQ RINAGASRKE DFYTVETITS GSSCKCACVA
PPSALNPCEG DFRLQKLREA DSQDLKLSTI IDMLEGAFYG LDLLKLHSVT TKLVGRVDKL
EEEVSKNLTK ENEQIKEDME EIRTEMNKRG KENCSENILD SMPDIRSALQ RDAAAAYAHP
EYEERFLQEE TVSQQINSIE LLQTRPLALP EVVKSQRPLQ RQVHLRGRPA SQPTVIRGIT
YYKAKVSEEE NDIEEQQDEF FSGDNGVDLL IEDQLLRHNG LMTSVTRRPA ATRQGHSTAV
TSDLNARTAP WSSALPQPST SDPSIANHAS VGPTLQTTSV SPDPTRESVL QPSPQVPATT
VAHTATQQPA APAPPAVSPR EALMEAMHTV PVPPTTVRTD SLGKDAPAGW GTTPASPTLS
PEEEDDIRNV IGRCKDTLST ITGPTTQNTY GRNEGAWMKD PLAKDERIYV TNYYYGNTLV
EFRNLENFKQ GRWSNSYKLP YSWIGTGHVV YNGAFYYNRA FTRNIIKYDL KQRYVAAWAM
LHDVAYEEAT PWRWQGHSDV DFAVDENGLW LIYPALDDEG FSQEVIVLSK LNAADLSTQK
ETTWRTGLRR NFYGNCFVIC GVLYAVDSYN QRNANISYAF DTHTNTQIVP RLLFENEYSY
TTQIDYNPKD RLLYAWDNGH QVTYHVIFAY
