OLSB_RHOCB
ID OLSB_RHOCB Reviewed; 259 AA.
AC D5AQD6;
DT 07-APR-2021, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 1.
DT 25-MAY-2022, entry version 45.
DE RecName: Full=L-ornithine N(alpha)-acyltransferase {ECO:0000305};
DE EC=2.3.2.30 {ECO:0000250|UniProtKB:Q92SJ1};
GN Name=olsB {ECO:0000303|PubMed:16856942};
GN OrderedLocusNames=RCAP_rcc02998 {ECO:0000312|EMBL:ADE86725.1};
OS Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC Rhodobacteraceae; Rhodobacter.
OX NCBI_TaxID=272942;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-309 / NBRC 16581 / SB1003;
RX PubMed=20418398; DOI=10.1128/jb.00366-10;
RA Strnad H., Lapidus A., Paces J., Ulbrich P., Vlcek C., Paces V.,
RA Haselkorn R.;
RT "Complete genome sequence of the photosynthetic purple nonsulfur bacterium
RT Rhodobacter capsulatus SB 1003.";
RL J. Bacteriol. 192:3545-3546(2010).
RN [2]
RP FUNCTION, PATHWAY, AND DISRUPTION PHENOTYPE.
RC STRAIN=MT1131;
RX PubMed=16856942; DOI=10.1111/j.1365-2958.2006.05253.x;
RA Aygun-Sunar S., Mandaci S., Koch H.G., Murray I.V., Goldfine H., Daldal F.;
RT "Ornithine lipid is required for optimal steady-state amounts of c-type
RT cytochromes in Rhodobacter capsulatus.";
RL Mol. Microbiol. 61:418-435(2006).
CC -!- FUNCTION: Catalyzes the first step in the biosynthesis of ornithine
CC lipids, which are phosphorus-free membrane lipids (Probable). Catalyzes
CC the 3-hydroxyacyl-acyl carrier protein-dependent acylation of ornithine
CC to form lyso-ornithine lipid (LOL) (By similarity).
CC {ECO:0000250|UniProtKB:Q92SJ1, ECO:0000305|PubMed:16856942}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3R)-hydroxyacyl-[ACP] + L-ornithine = a lyso-ornithine
CC lipid + H(+) + holo-[ACP]; Xref=Rhea:RHEA:20633, Rhea:RHEA-COMP:9685,
CC Rhea:RHEA-COMP:9945, ChEBI:CHEBI:15378, ChEBI:CHEBI:46911,
CC ChEBI:CHEBI:64479, ChEBI:CHEBI:78827, ChEBI:CHEBI:138482;
CC EC=2.3.2.30; Evidence={ECO:0000250|UniProtKB:Q92SJ1};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20634;
CC Evidence={ECO:0000250|UniProtKB:Q92SJ1};
CC -!- PATHWAY: Lipid metabolism. {ECO:0000269|PubMed:16856942}.
CC -!- DISRUPTION PHENOTYPE: Mutant lacking this gene is unable to produce
CC ornithine lipids. {ECO:0000269|PubMed:16856942}.
CC -!- SIMILARITY: Belongs to the acetyltransferase family. OlsB subfamily.
CC {ECO:0000305}.
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DR EMBL; CP001312; ADE86725.1; -; Genomic_DNA.
DR RefSeq; WP_013068698.1; NC_014034.1.
DR AlphaFoldDB; D5AQD6; -.
DR SMR; D5AQD6; -.
DR STRING; 272942.RCAP_rcc02998; -.
DR EnsemblBacteria; ADE86725; ADE86725; RCAP_rcc02998.
DR GeneID; 31491793; -.
DR KEGG; rcp:RCAP_rcc02998; -.
DR eggNOG; COG3176; Bacteria.
DR HOGENOM; CLU_058962_1_1_5; -.
DR OMA; YLRLGAW; -.
DR OrthoDB; 886192at2; -.
DR Proteomes; UP000002361; Chromosome.
DR GO; GO:0043810; F:ornithine-acyl [acyl carrier protein] N-acyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR SUPFAM; SSF55729; SSF55729; 1.
PE 3: Inferred from homology;
KW Acyltransferase; Lipid biosynthesis; Lipid metabolism; Reference proteome;
KW Transferase.
FT CHAIN 1..259
FT /note="L-ornithine N(alpha)-acyltransferase"
FT /id="PRO_0000452114"
SQ SEQUENCE 259 AA; 29315 MW; D8273E969114CF9B CRC64;
MAAAPLSYEI RLARDAQEIR ASQRLRYAVF VEELGGAGPL IDHENRLEAD EFDPLYDHLV
LIDATKPEED LDRVVAAYRL LRSDRAAEIG RFYCDAEYDL TPLRASGRRL LELGRSCVHP
DHRGGAAMLM LWNALADYVL AHEIEILFGV ASFHGTDVAA LQQPLAWLHH HHLAPEGLRP
RARQFQRMDL VAKEALDRRA ALDAMPNLIK AYLRLGGFVG EGAFVDRPFN TTDVMLLMDT
QAMSEKHREF YTRRVEGRG
