ID   OLVTN_PHONI             Reviewed;           8 AA.
AC   B3EWR9;
DT   28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2012, sequence version 1.
DT   25-MAY-2022, entry version 8.
DE   RecName: Full=Oligoventin {ECO:0000303|PubMed:28119686};
OS   Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Entelegynae; Lycosoidea; Ctenidae; Phoneutria.
OX   NCBI_TaxID=6918;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, TISSUE SPECIFICITY, AND MASS SPECTROMETRY.
RC   TISSUE=Egg {ECO:0000269|PubMed:28119686};
RX   PubMed=28119686; DOI=10.3389/fimmu.2016.00664;
RA   Candido-Ferreira I.L., Kronenberger T., Sayegh R.S., Batista I.F.,
RA   da Silva Junior P.I.;
RT   "Evidence of an Antimicrobial Peptide Signature Encrypted in HECT E3
RT   Ubiquitin Ligases.";
RL   Front. Immunol. 7:664-664(2016).
CC   -!- FUNCTION: Has weak antibacterial activity against Gram-positive
CC       bacteria M.luteus A270 (MIC=47.2-94.5 uM), S.aureus ATCC 29213
CC       (MIC=94.5-188.9 uM) and S.epidermidis ATCC 12228 (MIC=94.5-188.9 uM) as
CC       well as against Gram-negative bacterium S.marcescens ATCC 4112
CC       (MIC=23.5-47.2 uM). Also active against yeast C.albicans MDM8
CC       (MIC=94.5-188.9 uM). Has no activity against Gram-negative bacteria
CC       E.coli ATCC 25922, E.coli SBS363 and P.aeruginosa ATCC 27853 or against
CC       clinical isolates of C.albicans, C.krusei, C.glabrata, C.parapsilosis,
CC       C.tropicalis, C.guilliermondii or Trichosporon sp.
CC       {ECO:0000269|PubMed:28119686}.
CC   -!- TISSUE SPECIFICITY: Expressed in egg (at protein level).
CC       {ECO:0000269|PubMed:28119686}.
CC   -!- MASS SPECTROMETRY: Mass=1061.4; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:28119686};
CC   -!- MISCELLANEOUS: Possibly derived from Nedd4 E3 ubiquitin ligase.
CC       {ECO:0000305|PubMed:28119686}.
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DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing.
FT   PEPTIDE         1..8
FT                   /note="Oligoventin"
FT                   /evidence="ECO:0000269|PubMed:28119686"
FT                   /id="PRO_0000420435"
SQ   SEQUENCE   8 AA;  1062 MW;  86640B1735B9D776 CRC64;
     QPFSLERW