ID   OMBP_MANSE              Reviewed;         274 AA.
AC   P31420;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Ommochrome-binding protein;
DE            Short=OBP;
DE   AltName: Full=YCP;
DE   Flags: Precursor;
OS   Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Sphingidae; Sphinginae; Sphingini; Manduca.
OX   NCBI_TaxID=7130;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Hemolymph;
RX   PubMed=8428907; DOI=10.1016/s0021-9258(18)53780-7;
RA   Yepiz-Plascencia G.M., Ho C., Martel R.R., Law J.H.;
RT   "Molecular cloning and sequence of a novel ommochrome-binding protein cDNA
RT   from an insect, Manduca sexta.";
RL   J. Biol. Chem. 268:2337-2340(1993).
RN   [2]
RP   CHARACTERIZATION, AND PROTEIN SEQUENCE OF 19-49.
RC   TISSUE=Hemolymph;
RX   PubMed=1939173; DOI=10.1016/s0021-9258(18)54650-0;
RA   Martel R.R., Law J.H.;
RT   "Purification and properties of an ommochrome-binding protein from the
RT   hemolymph of the tobacco hornworm, Manduca sexta.";
RL   J. Biol. Chem. 266:21392-21398(1991).
CC   -!- FUNCTION: Binds to an ommochrome, ommatin D which is a yellow
CC       chromophore. May be involved in guiding the chromophore through the
CC       hemolymph from the epidermis to the gut.
CC   -!- SUBUNIT: Monomer.
CC   -!- TISSUE SPECIFICITY: Present in larval hemolymph and synthesized by the
CC       fat body.
CC   -!- DEVELOPMENTAL STAGE: Early larval stages produce only traces of obp,
CC       but its synthesis increases dramatically during the fifth larval
CC       instar, then it decreases but persists in hemolymph of adults.
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DR   EMBL; L00975; AAA29324.1; -; mRNA.
DR   PIR; A45198; A45198.
DR   AlphaFoldDB; P31420; -.
DR   SMR; P31420; -.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Glycoprotein; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000269|PubMed:1939173"
FT   CHAIN           19..274
FT                   /note="Ommochrome-binding protein"
FT                   /id="PRO_0000021887"
FT   CARBOHYD        183
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        19
FT                   /note="L -> S (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        22
FT                   /note="C -> S (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        24
FT                   /note="V -> S (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        24
FT                   /note="V -> T (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        49
FT                   /note="P -> E (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   274 AA;  30615 MW;  D0090341BDE6E130 CRC64;
     MKLLILTICA LHVNQMMALK DCVVVNGKNY GKEVLKDNIH QAYQLSFDPQ QNTLFFSYSD
     EVDSKTVLKM GYLNLATKSF GEISGVKDGM ATAVDTTNHI VYLGGKDGIY TYDYATKSAK
     NIGVTSLSIW QMFYCPIHGL FFTTSDEKPY VFKDGQVNQI VEASSSKTRV MAVGEHHDVF
     FANSSGIFLF NHHTNKVIDL GDYNVNAFTK DSKGKLYFSS PVGFYAVNEA DRKMNKLISE
     TGEDSIWGAA FDKDDNIVYS NEDNIVKLVP KDKC