OMCA_CHLP6
ID OMCA_CHLP6 Reviewed; 87 AA.
AC F0T376; P27606;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 03-MAY-2011, sequence version 1.
DT 03-AUG-2022, entry version 33.
DE RecName: Full=Small cysteine-rich outer membrane protein omcA;
DE Short=Small-CRP;
DE AltName: Full=9 kDa cysteine-rich lipoprotein;
DE Short=9KD-CRP;
DE Flags: Precursor;
GN Name=omcA; Synonyms=envA; OrderedLocusNames=CPSIT_0207, G5O_0209;
OS Chlamydophila psittaci (strain ATCC VR-125 / 6BC) (Chlamydia psittaci).
OC Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=331636;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBUNIT, AND PALMITOYLATION AT CYS-20.
RC STRAIN=ATCC VR-125 / 6BC;
RX PubMed=2050637; DOI=10.1128/jb.173.12.3821-3830.1991;
RA Everett K.D.E., Hatch T.P.;
RT "Sequence analysis and lipid modification of the cysteine-rich envelope
RT proteins of Chlamydia psittaci 6BC.";
RL J. Bacteriol. 173:3821-3830(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC VR-125 / 6BC;
RX PubMed=21441521; DOI=10.1128/jb.00236-11;
RA Voigt A., Schofl G., Heidrich A., Sachse K., Saluz H.P.;
RT "Full-length de novo sequence of the Chlamydophila psittaci type strain,
RT 6BC.";
RL J. Bacteriol. 193:2662-2663(2011).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC VR-125 / 6BC;
RX PubMed=21622741; DOI=10.1128/jb.05277-11;
RA Grinblat-Huse V., Drabek E.F., Creasy H.H., Daugherty S.C., Jones K.M.,
RA Santana-Cruz I., Tallon L.J., Read T.D., Hatch T.P., Bavoil P., Myers G.S.;
RT "Genome sequences of the zoonotic pathogens Chlamydia psittaci 6BC and
RT Cal10.";
RL J. Bacteriol. 193:4039-4040(2011).
RN [4]
RP BLOCKAGE OF N-TERMINUS, PALMITOYLATION AT CYS-20, AND DIACYLGLYCEROL AT
RP CYS-20.
RC STRAIN=ATCC VR-125 / 6BC;
RX PubMed=7928970; DOI=10.1128/jb.176.19.6082-6087.1994;
RA Everett K.D.E., Desiderio D.M., Hatch T.P.;
RT "Characterization of lipoprotein envA in Chlamydia psittaci 6BC.";
RL J. Bacteriol. 176:6082-6087(1994).
RN [5]
RP SUBCELLULAR LOCATION.
RC STRAIN=ATCC VR-125 / 6BC;
RX PubMed=7532170; DOI=10.1128/jb.177.4.877-882.1995;
RA Everett K.D.E., Hatch T.P.;
RT "Architecture of the cell envelope of Chlamydia psittaci 6BC.";
RL J. Bacteriol. 177:877-882(1995).
CC -!- FUNCTION: In elementary bodies (EBs, the infectious stage, which is
CC able to survive outside the host cell) provides the structural
CC integrity of the outer envelope through disulfide cross-links with the
CC large cysteine-rich periplasmic protein and the major outer membrane
CC porin. It has been described in publications as the Sarkosyl-insoluble
CC COMC (Chlamydia outer membrane complex), and serves as the functional
CC equivalent of peptidoglycan.
CC -!- SUBUNIT: Part of a disulfide cross-linked outer membrane complex (COMC)
CC composed of the major outer membrane porin (MOMP), the small cysteine-
CC rich protein (omcA) and the large cysteine-rich periplasmic protein
CC (omcB). {ECO:0000269|PubMed:2050637}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305|PubMed:7532170};
CC Lipid-anchor {ECO:0000305|PubMed:7532170}. Note=The protein moiety
CC probably penetrates into the periplasm.
CC -!- PTM: N-terminal amide-linked and S-diacylglycerol cysteine-linked to
CC 16:0, 18:0, 15:0 branched, and 17:0 branched fatty acids (ratio
CC 6:5:3:4) in the EB stage (PubMed:7928970). The exact distribution of
CC fatty acids has not been determined. {ECO:0000269|PubMed:7928970}.
CC -!- PTM: The N-terminus is blocked.
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DR EMBL; M61116; AAB61618.1; -; Genomic_DNA.
DR EMBL; CP002549; ADZ18491.1; -; Genomic_DNA.
DR EMBL; CP002586; AEB55212.1; -; Genomic_DNA.
DR PIR; A39439; A39439.
DR RefSeq; WP_006342860.1; NC_017287.1.
DR AlphaFoldDB; F0T376; -.
DR GeneID; 12242468; -.
DR KEGG; chb:G5O_0209; -.
DR KEGG; chp:CPSIT_0207; -.
DR PATRIC; fig|331636.3.peg.195; -.
DR HOGENOM; CLU_2463467_0_0_0; -.
DR OMA; PDGRCKQ; -.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR InterPro; IPR003517; Cys-rich_OMP3_Chlamydia.
DR Pfam; PF03503; Chlam_OMP3; 1.
DR PRINTS; PR01335; CHLAMIDIAOM3.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 1: Evidence at protein level;
KW Cell outer membrane; Cell shape; Disulfide bond; Lipoprotein; Membrane;
KW Palmitate; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT CHAIN 20..87
FT /note="Small cysteine-rich outer membrane protein omcA"
FT /id="PRO_0000410952"
FT LIPID 20
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000305|PubMed:2050637,
FT ECO:0000305|PubMed:7928970"
FT LIPID 20
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000305|PubMed:7928970"
SQ SEQUENCE 87 AA; 8981 MW; EA27764B791E8180 CRC64;
MKKAVLLATV FCGVVGLTSC CRIVDCCFED PCAPKPCNPC GNKKDKGCSP CGVYTPSCSK
PCGSECNPGV QGPQAKGCTS LDGRCKQ
