OMCA_CHLPN
ID OMCA_CHLPN Reviewed; 90 AA.
AC Q9Z7Z5; Q46183; Q9JQI5;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 116.
DE RecName: Full=Small cysteine-rich outer membrane protein OmcA;
DE Short=Small-CRP;
DE AltName: Full=9 kDa cysteine-rich lipoprotein;
DE Short=9KD-CRP;
DE Flags: Precursor;
GN Name=omcA; OrderedLocusNames=CPn_0558, CP_0193, CpB0580;
OS Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=83558;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DEVELOPMENTAL STAGE.
RC STRAIN=IOL-207;
RX PubMed=7582008; DOI=10.1099/13500872-141-10-2489;
RA Watson M.W., Clarke I.N., Everson J.S., Lambden P.R.;
RT "The CrP operon of Chlamydia psittaci and Chlamydia pneumoniae.";
RL Microbiology 141:2489-2497(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CWL029;
RX PubMed=10192388; DOI=10.1038/7716;
RA Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL Nat. Genet. 21:385-389(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR39;
RX PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA Salzberg S.L., Eisen J.A., Fraser C.M.;
RT "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT AR39.";
RL Nucleic Acids Res. 28:1397-1406(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J138;
RX PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from
RT Japan and CWL029 from USA.";
RL Nucleic Acids Res. 28:2311-2314(2000).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW-183;
RA Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT other Chlamydia strains based on whole genome sequence analysis.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In elementary bodies (EBs, the infectious stage, which is
CC able to survive outside the host cell) provides the structural
CC integrity of the outer envelope through disulfide cross-links with the
CC large cysteine-rich periplasmic protein and the major outer membrane
CC porin. It has been described in publications as the Sarkosyl-insoluble
CC COMC (Chlamydia outer membrane complex), and serves as the functional
CC equivalent of peptidoglycan (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Part of a disulfide cross-linked outer membrane complex (COMC)
CC composed of the major outer membrane porin (MOMP), the small cysteine-
CC rich protein (OmcA) and the large cysteine-rich periplasmic protein
CC (OmcB). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000255|PROSITE-ProRule:PRU00303}. Note=The protein moiety
CC probably penetrates into the periplasm.
CC -!- DEVELOPMENTAL STAGE: It is present but the disulfide bonds are reduced
CC in reticulate bodies (RBs). {ECO:0000269|PubMed:7582008}.
CC -!- CAUTION: In strain IOL-207 the Cys that is thought to be palmitoylated
CC is mutated to Ser; presumably the following Cys is acylated instead.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X53511; CAA37589.1; -; Genomic_DNA.
DR EMBL; AE001363; AAD18698.1; -; Genomic_DNA.
DR EMBL; AE002161; AAF38066.1; -; Genomic_DNA.
DR EMBL; BA000008; BAA98764.1; -; Genomic_DNA.
DR EMBL; AE009440; AAP98509.1; -; Genomic_DNA.
DR PIR; A72064; A72064.
DR PIR; B86560; B86560.
DR RefSeq; NP_224754.1; NC_000922.1.
DR RefSeq; WP_010883196.1; NZ_LN847257.1.
DR AlphaFoldDB; Q9Z7Z5; -.
DR STRING; 115713.CPn_0558; -.
DR EnsemblBacteria; AAD18698; AAD18698; CPn_0558.
DR EnsemblBacteria; AAF38066; AAF38066; CP_0193.
DR GeneID; 45050602; -.
DR KEGG; cpa:CP_0193; -.
DR KEGG; cpj:omcA; -.
DR KEGG; cpn:CPn_0558; -.
DR KEGG; cpt:CpB0580; -.
DR PATRIC; fig|115713.3.peg.619; -.
DR HOGENOM; CLU_2463467_0_0_0; -.
DR OrthoDB; 1883796at2; -.
DR Proteomes; UP000000583; Chromosome.
DR Proteomes; UP000000801; Chromosome.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR InterPro; IPR003517; Cys-rich_OMP3_Chlamydia.
DR Pfam; PF03503; Chlam_OMP3; 1.
DR PRINTS; PR01335; CHLAMIDIAOM3.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 2: Evidence at transcript level;
KW Cell outer membrane; Cell shape; Disulfide bond; Lipoprotein; Membrane;
KW Palmitate; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT CHAIN 20..90
FT /note="Small cysteine-rich outer membrane protein OmcA"
FT /id="PRO_0000018155"
FT REGION 69..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 20
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000305"
FT LIPID 20
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000305"
FT VARIANT 20
FT /note="C -> S (in strain: IOL-207)"
SQ SEQUENCE 90 AA; 9410 MW; 5B03725248B6260B CRC64;
MKKAVLIAAM FCGVVSLSSC CRIVDCCFED PCAPSSCNPC EVIRKKERSC GGNACGSYVP
SCSNPCGSTE CNSQSPQVKG CTSPDGRCKQ
