ID   OMCB_CHLAB              Reviewed;         557 AA.
AC   Q9AIS7; Q5L6T2;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Large cysteine-rich periplasmic protein OmcB;
DE            Short=Large-CRP;
DE   AltName: Full=60 kDa CRP;
DE   AltName: Full=60 kDa outer membrane protein;
DE   AltName: Full=Cysteine-rich outer membrane protein;
DE   Flags: Precursor;
GN   Name=omcB; Synonyms=cmcB; OrderedLocusNames=CAB181;
OS   Chlamydia abortus (strain DSM 27085 / S26/3) (Chlamydophila abortus).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=218497;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=EBA;
RX   PubMed=11211261; DOI=10.1099/00207713-51-1-203;
RA   Bush R.M., Everett K.D.E.;
RT   "Molecular evolution of the Chlamydiaceae.";
RL   Int. J. Syst. Evol. Microbiol. 51:203-220(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 27085 / S26/3;
RX   PubMed=15837807; DOI=10.1101/gr.3684805;
RA   Thomson N.R., Yeats C., Bell K., Holden M.T.G., Bentley S.D.,
RA   Livingstone M., Cerdeno-Tarraga A.-M., Harris B., Doggett J., Ormond D.,
RA   Mungall K., Clarke K., Feltwell T., Hance Z., Sanders M., Quail M.A.,
RA   Price C., Barrell B.G., Parkhill J., Longbottom D.;
RT   "The Chlamydophila abortus genome sequence reveals an array of variable
RT   proteins that contribute to interspecies variation.";
RL   Genome Res. 15:629-640(2005).
CC   -!- FUNCTION: In elementary bodies (EBs, the infectious stage, which is
CC       able to survive outside the host cell) provides the structural
CC       integrity of the outer envelope through disulfide cross-links with the
CC       small cysteine-rich protein and the major outer membrane porin. It has
CC       been described in publications as the Sarkosyl-insoluble COMC
CC       (Chlamydia outer membrane complex), and serves as the functional
CC       equivalent of peptidoglycan. It is present but the disulfide bonds are
CC       reduced in reticulate bodies (RBs) (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of a disulfide cross-linked outer membrane complex (COMC)
CC       composed of the major outer membrane porin (MOMP), the small cysteine-
CC       rich protein (OmcA) and the large cysteine-rich periplasmic protein
CC       (OmcB). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305}.
CC   -!- CAUTION: Was thought to be an outer membrane protein as it is part of a
CC       disulfide cross-linked complex that is insoluble in the detergent
CC       Sarkosyl; however based on experiments in C.psittaci it is likely to be
CC       periplasmic. {ECO:0000305}.
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DR   EMBL; AF240773; AAG60550.1; -; Genomic_DNA.
DR   EMBL; CR848038; CAH63639.1; -; Genomic_DNA.
DR   RefSeq; WP_011096885.1; NC_004552.2.
DR   AlphaFoldDB; Q9AIS7; -.
DR   EnsemblBacteria; CAH63639; CAH63639; CAB181.
DR   KEGG; cab:CAB181; -.
DR   eggNOG; COG1361; Bacteria.
DR   HOGENOM; CLU_029611_0_0_0; -.
DR   OMA; CEAEFVS; -.
DR   OrthoDB; 1049286at2; -.
DR   Proteomes; UP000001012; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   InterPro; IPR003506; Chlam_OMP6.
DR   InterPro; IPR001434; DUF11.
DR   Pfam; PF03504; Chlam_OMP6; 1.
DR   Pfam; PF01345; DUF11; 2.
DR   PRINTS; PR01336; CHLAMIDIAOM6.
DR   TIGRFAMs; TIGR01451; B_ant_repeat; 1.
PE   3: Inferred from homology;
KW   Cell shape; Disulfide bond; Periplasm; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..40
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000248862"
FT   CHAIN           41..557
FT                   /note="Large cysteine-rich periplasmic protein OmcB"
FT                   /id="PRO_0000248863"
SQ   SEQUENCE   557 AA;  59761 MW;  817A20B071AD9609 CRC64;
     MSKLIRRVVT VLALTSMASS FASGKIEAAA AESLATRFIA STENSNDNVL QATAKKVRFG
     RNKNQRQEQK HTGAFCDKEF YPCEGGQCQS VDTTQESCYG KMYCVRVNDD CNVEISQAVP
     EYATVGSPYP IEILAVGKKD CVNVVITQQL PCEVEFVSSD PATTPTSDSK LIWTIDCLGQ
     GEKCKITVWV KPLKEGCCFT AATVCACPEL RSYTKCGQPA ICIKQEGPEC ACLRCPVCYK
     IEVCNTGSAI ARNVVVDNPV PDGYTHASGQ RVLSFNLGDM RPGDSKCFSV EFCPQKRGKI
     TNVATVSYCG GHKCSANVTT VVNEPCVQVN ISGADWSYVC KPVEYTIVVS NLGDLKLYDV
     VVEDTVPSGA TILEAEGAEI CCNKAVWCIK EMCPGETLQF KVVAKAQSPG KFTNQVVVKT
     NSDCGTCTSC AEATTHWKGL AATHMCVIDT NDPICVGENT VYRICVTNRG SAEDTNVSLI
     LKFSKELQPV SSSGPTKGTI TGNTVVFDAL PKLGSKESVE FSVTLKGIAP GDARGEAILS
     SDTLTVPVAD TENTHVY