ID   OMCB_CHLCV              Reviewed;         558 AA.
AC   P94664; Q7BYF2;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Large cysteine-rich periplasmic protein OmcB;
DE            Short=Large-CRP;
DE   AltName: Full=60 kDa CRP;
DE   AltName: Full=60 kDa outer membrane protein;
DE   AltName: Full=Cysteine-rich outer membrane protein;
DE   Flags: Precursor;
GN   Name=omcB; Synonyms=omp2; OrderedLocusNames=CCA_00185;
OS   Chlamydia caviae (strain ATCC VR-813 / DSM 19441 / 03DC25 / GPIC)
OS   (Chlamydophila caviae).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=227941;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC VR-813 / DSM 19441 / 03DC25 / GPIC;
RX   PubMed=8918247; DOI=10.1016/0378-1119(96)00241-7;
RA   Hsia R.-C., Bavoil P.M.;
RT   "Sequence analysis of the omp2 region of Chlamydia psittaci strain GPIC:
RT   structural and functional implications.";
RL   Gene 176:155-162(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-813 / DSM 19441 / 03DC25 / GPIC;
RX   PubMed=12682364; DOI=10.1093/nar/gkg321;
RA   Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T.,
RA   Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A.,
RA   Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O.,
RA   Salzberg S.L., Hsia R.-C., McClarty G., Rank R.G., Bavoil P.M.,
RA   Fraser C.M.;
RT   "Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC):
RT   examining the role of niche-specific genes in the evolution of the
RT   Chlamydiaceae.";
RL   Nucleic Acids Res. 31:2134-2147(2003).
CC   -!- FUNCTION: In elementary bodies (EBs, the infectious stage, which is
CC       able to survive outside the host cell) provides the structural
CC       integrity of the outer envelope through disulfide cross-links with the
CC       small cysteine-rich protein and the major outer membrane porin. It has
CC       been described in publications as the Sarkosyl-insoluble COMC
CC       (Chlamydia outer membrane complex), and serves as the functional
CC       equivalent of peptidoglycan. It is present but the disulfide bonds are
CC       reduced in reticulate bodies (RBs) (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of a disulfide cross-linked outer membrane complex (COMC)
CC       composed of the major outer membrane porin (MOMP), the small cysteine-
CC       rich protein (OmcA) and the large cysteine-rich periplasmic protein
CC       (OmcB). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305}.
CC   -!- CAUTION: Was thought to be an outer membrane protein as it is part of a
CC       disulfide cross-linked complex that is insoluble in the detergent
CC       Sarkosyl; however based on experiments in C.psittaci it is likely to be
CC       periplasmic. {ECO:0000305}.
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DR   EMBL; U41759; AAB41143.1; -; Genomic_DNA.
DR   EMBL; AE015925; AAP04936.1; -; Genomic_DNA.
DR   RefSeq; WP_011006157.1; NC_003361.3.
DR   AlphaFoldDB; P94664; -.
DR   STRING; 227941.CCA_00185; -.
DR   EnsemblBacteria; AAP04936; AAP04936; CCA_00185.
DR   KEGG; cca:CCA_00185; -.
DR   eggNOG; COG1361; Bacteria.
DR   HOGENOM; CLU_029611_0_0_0; -.
DR   OMA; CEAEFVS; -.
DR   OrthoDB; 1049286at2; -.
DR   Proteomes; UP000002193; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   InterPro; IPR003506; Chlam_OMP6.
DR   InterPro; IPR001434; DUF11.
DR   Pfam; PF03504; Chlam_OMP6; 1.
DR   Pfam; PF01345; DUF11; 3.
DR   PRINTS; PR01336; CHLAMIDIAOM6.
DR   TIGRFAMs; TIGR01451; B_ant_repeat; 1.
PE   3: Inferred from homology;
KW   Cell shape; Disulfide bond; Periplasm; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..40
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000248864"
FT   CHAIN           41..558
FT                   /note="Large cysteine-rich periplasmic protein OmcB"
FT                   /id="PRO_0000248865"
SQ   SEQUENCE   558 AA;  60214 MW;  452E2BD79078935C CRC64;
     MSKLFRRVVT VLALTSMASS FASGKIEAAA AESLATRFIA SAENSDDNIS QRKAKKVRFG
     RNKYQKQEQK NNGPYCDKEF YPCQDGSCQS SVDTKQEPCY GKMYCVRVSD DSNVEISQAV
     PEYATVGSPY PIEILAVGKR DCVNVVITQQ LPCEVEFISS DPATTPTSDS KLIWTIDRLG
     QGERCKITVW VKPLKEGCCF TAATVCACPE LRSYTKCGQP AICIKQEGPE CACLRCPVCY
     KIEVTNTGSA IARGVVVDNP VPDGYSHPSG QRVLSFNLGD MRPGDTKCFT VEFCPQKRGK
     ITNVATVSYC GGHKCSANVT TVINEPCVQV NISGNDWSYV CKPVEYTIVV SNPGDLKLYD
     VVIEDLIPSG ITILEAPGAE ICCNKAVWCI KEMCPGETLQ FKVVAKAQTP GKFTNQVSVK
     TNSDCGSCTS CAEVTTHWKG LAATHMCVID TNDPICVGEN TVYRICVTNR GSAEDTNVSL
     ILKFSKELQP VSSSGPTKGT ITGNTVVFDA LPKLGSKESV EFSVTLKGVA PGDARGEAIL
     SSDTLTVPVA DTENTHVY