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OMCB_CHLPN
ID   OMCB_CHLPN              Reviewed;         556 AA.
AC   P23700; Q9JQI6;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   25-MAY-2022, entry version 143.
DE   RecName: Full=Large cysteine-rich periplasmic protein OmcB;
DE            Short=Large-CRP;
DE   AltName: Full=60 kDa cysteine-rich OMP;
DE            Short=60 kDa CRP;
DE   AltName: Full=60 kDa outer membrane protein;
DE   AltName: Full=Cysteine-rich outer membrane protein;
DE   Flags: Precursor;
GN   Name=omcB; Synonyms=omp2; OrderedLocusNames=CPn_0557, CP_0195, CpB0579;
OS   Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=83558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=IOL-207;
RX   PubMed=2402463; DOI=10.1093/nar/18.17.5299;
RA   Watson M.W., Al-Mahdawi S., Lamden P.R., Clarke I.N.;
RT   "The nucleotide sequence of the 60 kDa cysteine rich outer membrane protein
RT   of Chlamydia pneumoniae strain IOL-207.";
RL   Nucleic Acids Res. 18:5299-5299(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DEVELOPMENTAL STAGE.
RC   STRAIN=IOL-207;
RX   PubMed=7582008; DOI=10.1099/13500872-141-10-2489;
RA   Watson M.W., Clarke I.N., Everson J.S., Lambden P.R.;
RT   "The CrP operon of Chlamydia psittaci and Chlamydia pneumoniae.";
RL   Microbiology 141:2489-2497(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CWL029;
RX   PubMed=10192388; DOI=10.1038/7716;
RA   Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA   Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT   "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL   Nat. Genet. 21:385-389(1999).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AR39;
RX   PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA   Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA   Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA   Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA   Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA   Salzberg S.L., Eisen J.A., Fraser C.M.;
RT   "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT   AR39.";
RL   Nucleic Acids Res. 28:1397-1406(2000).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J138;
RX   PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA   Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA   Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT   "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from
RT   Japan and CWL029 from USA.";
RL   Nucleic Acids Res. 28:2311-2314(2000).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND DISCUSSION OF SEQUENCE.
RC   STRAIN=J138;
RX   PubMed=10839753; DOI=10.1086/315616;
RA   Shirai M., Hirakawa H., Ouchi K., Tabuchi M., Kishi F., Kimoto M.,
RA   Takeuchi H., Nishida J., Shibata K., Fujinaga R., Yoneda H., Matsushima H.,
RA   Tanaka C., Furukawa S., Miura K., Nakazawa A., Ishii K., Shiba T.,
RA   Hattori M., Kuhara S., Nakazawa T.;
RT   "Comparison of outer membrane protein genes omp and pmp in the whole genome
RT   sequences of Chlamydia pneumoniae isolates from Japan and the United
RT   States.";
RL   J. Infect. Dis. 181 Suppl. 3:S524-S527(2000).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TW-183;
RA   Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA   Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT   "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT   other Chlamydia strains based on whole genome sequence analysis.";
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: In elementary bodies (EBs, the infectious stage, which is
CC       able to survive outside the host cell) provides the structural
CC       integrity of the outer envelope through disulfide cross-links with the
CC       small cysteine-rich protein and the major outer membrane porin. It has
CC       been described in publications as the Sarkosyl-insoluble COMC
CC       (Chlamydia outer membrane complex), and serves as the functional
CC       equivalent of peptidoglycan (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of a disulfide cross-linked outer membrane complex (COMC)
CC       composed of the major outer membrane porin (MOMP), the small cysteine-
CC       rich protein (OmcA) and the large cysteine-rich periplasmic protein
CC       (OmcB). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: It is present but the disulfide bonds are reduced
CC       in the intracellular reticulate bodies (RBs).
CC       {ECO:0000269|PubMed:7582008}.
CC   -!- CAUTION: Was thought to be an outer membrane protein as it is part of a
CC       disulfide cross-linked complex that is insoluble in the detergent
CC       Sarkosyl; however based on experiments in C.psittaci it is likely to be
CC       periplasmic. {ECO:0000305}.
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DR   EMBL; X53511; CAA37590.1; -; Genomic_DNA.
DR   EMBL; AE001363; AAD18697.1; -; Genomic_DNA.
DR   EMBL; AE002161; AAF38068.1; -; Genomic_DNA.
DR   EMBL; BA000008; BAA98763.1; -; Genomic_DNA.
DR   EMBL; AE009440; AAP98508.1; -; Genomic_DNA.
DR   PIR; A86560; A86560.
DR   PIR; S12602; S12602.
DR   RefSeq; NP_224753.1; NC_000922.1.
DR   RefSeq; WP_010883195.1; NZ_LN847257.1.
DR   AlphaFoldDB; P23700; -.
DR   STRING; 115711.CP_0195; -.
DR   EnsemblBacteria; AAD18697; AAD18697; CPn_0557.
DR   EnsemblBacteria; AAF38068; AAF38068; CP_0195.
DR   KEGG; cpa:CP_0195; -.
DR   KEGG; cpj:omcB; -.
DR   KEGG; cpn:CPn_0557; -.
DR   KEGG; cpt:CpB0579; -.
DR   PATRIC; fig|115713.3.peg.618; -.
DR   eggNOG; COG1361; Bacteria.
DR   HOGENOM; CLU_029611_0_0_0; -.
DR   OrthoDB; 1049286at2; -.
DR   Proteomes; UP000000583; Chromosome.
DR   Proteomes; UP000000801; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   InterPro; IPR003506; Chlam_OMP6.
DR   InterPro; IPR001434; DUF11.
DR   Pfam; PF03504; Chlam_OMP6; 1.
DR   Pfam; PF01345; DUF11; 3.
DR   PRINTS; PR01336; CHLAMIDIAOM6.
DR   TIGRFAMs; TIGR01451; B_ant_repeat; 1.
PE   2: Evidence at transcript level;
KW   Cell shape; Disulfide bond; Periplasm; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..40
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000020164"
FT   CHAIN           41..556
FT                   /note="Large cysteine-rich periplasmic protein OmcB"
FT                   /id="PRO_0000020165"
FT   CONFLICT        412
FT                   /note="T -> I (in Ref. 6; AAP98508)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   556 AA;  59719 MW;  8D7ED9234CC99458 CRC64;
     MSKLIRRVVT VLALTSMASC FASGGIEAAV AESLITKIVA SAETKPAPVP MTAKKVRLVR
     RNKQPVEQKS RGAFCDKEFY PCEEGRCQPV EAQQESCYGR LYSVKVNDDC NVEICQSVPE
     YATVGSPYPI EILAIGKKDC VDVVITQQLP CEAEFVSSDP ETTPTSDGKL VWKIDRLGAG
     DKCKITVWVK PLKEGCCFTA ATVCACPELR SYTKCGQPAI CIKQEGPDCA CLRCPVCYKI
     EVVNTGSAIA RNVTVDNPVP DGYSHASGQR VLSFNLGDMR PGDKKVFTVE FCPQRRGQIT
     NVATVTYCGG HKCSANVTTV VNEPCVQVNI SGADWSYVCK PVEYSISVSN PGDLVLHDVV
     IQDTLPSGVT VLEAPGGEIC CNKVVWRIKE MCPGETLQFK LVVKAQVPGR FTNQVAVTSE
     SNCGTCTSCA ETTTHWKGLA ATHMCVLDTN DPICVGENTV YRICVTNRGS AEDTNVSLIL
     KFSKELQPIA SSGPTKGTIS GNTVVFDALP KLGSKESVEF SVTLKGIAPG DARGEAILSS
     DTLTSPVSDT ENTHVY
 
 
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