ID   OMCB_CHLTH              Reviewed;         547 AA.
AC   P0DJI2; P18586; P21354;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2012, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=Large cysteine-rich periplasmic protein OmcB, serovars L1/L3;
DE            Short=Large-CRP;
DE   AltName: Full=60 kDa CRP;
DE   AltName: Full=60 kDa outer membrane protein;
DE   AltName: Full=Cysteine-rich outer membrane protein;
DE   Contains:
DE     RecName: Full=Large cysteine-rich periplasmic protein OmcB, serovars L1/L3 isoform 1;
DE   Contains:
DE     RecName: Full=Large cysteine-rich periplasmic protein OmcB, serovars L1/L3 isoform 2;
DE   Flags: Precursor;
GN   Name=omcB; Synonyms=omp2, omp2B;
OS   Chlamydia trachomatis.
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=L1/440/LN;
RX   PubMed=3066701; DOI=10.1016/0378-1119(88)90047-9;
RA   Clarke I.N., Ward M.E., Lambden P.R.;
RT   "Molecular cloning and sequence analysis of a developmentally regulated
RT   cysteine-rich outer membrane protein from Chlamydia trachomatis.";
RL   Gene 71:307-314(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=L3/404;
RX   PubMed=1997423; DOI=10.1128/iai.59.3.1196-1201.1991;
RA   de la Maza L.M., Fiedler T.J., Carlson E.J., Markoff B.A., Peterson E.M.;
RT   "Sequence diversity of the 60-kilodalton protein and of a putative 15-
RT   kilodalton protein between the trachoma and lymphogranuloma venereum
RT   biovars of Chlamydia trachomatis.";
RL   Infect. Immun. 59:1196-1201(1991).
CC   -!- FUNCTION: In elementary bodies (EBs, the infectious stage, which is
CC       able to survive outside the host cell) provides the structural
CC       integrity of the outer envelope through disulfide cross-links with the
CC       small cysteine-rich protein and the major outer membrane protein. It
CC       has been described in publications as the Sarkosyl-insoluble COMC
CC       (Chlamydia outer membrane complex), and serves as the functional
CC       equivalent of peptidoglycan (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of a disulfide cross-linked outer membrane complex (COMC)
CC       composed of the major outer membrane porin (MOMP), the small cysteine-
CC       rich protein (OmcA) and the large cysteine-rich periplasmic protein
CC       (OmcB). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: It is present but the disulfide bonds are reduced
CC       in the intracellular reticulate bodies (RBs).
CC   -!- CAUTION: Was thought to be an outer membrane protein as it is part of a
CC       disulfide cross-linked complex that is insoluble in the detergent
CC       Sarkosyl; however based on experiments in C.psittaci it is likely to be
CC       periplasmic. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA23119.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; M35148; AAA23119.1; ALT_INIT; Genomic_DNA.
DR   EMBL; X54390; CAA38261.1; -; Genomic_DNA.
DR   PIR; A32244; A32244.
DR   RefSeq; WP_013984953.1; NZ_CVND01000004.1.
DR   AlphaFoldDB; P0DJI2; -.
DR   SMR; P0DJI2; -.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR003506; Chlam_OMP6.
DR   InterPro; IPR001434; DUF11.
DR   InterPro; IPR013783; Ig-like_fold.
DR   Pfam; PF03504; Chlam_OMP6; 1.
DR   Pfam; PF01345; DUF11; 3.
DR   PRINTS; PR01336; CHLAMIDIAOM6.
DR   TIGRFAMs; TIGR01451; B_ant_repeat; 2.
PE   2: Evidence at transcript level;
KW   Cell shape; Disulfide bond; Periplasm; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..547
FT                   /note="Large cysteine-rich periplasmic protein OmcB,
FT                   serovars L1/L3 isoform 1"
FT                   /id="PRO_0000020174"
FT   CHAIN           41..547
FT                   /note="Large cysteine-rich periplasmic protein OmcB,
FT                   serovars L1/L3 isoform 2"
FT                   /id="PRO_0000020175"
FT   REGION          45..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        51..65
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   547 AA;  58782 MW;  78CEB41CCF98472D CRC64;
     MNKLIRRAVT IFAVTSVASL FASGVLETSM AEFISTNVIS LADTKAKDNT SHKSKKARKN
     HSKETPVNRK KVAPVHESKA TGPKQDSCFG RMYTVKVNDD RNVEITQAVP KYATVGSPYP
     VEITATGKRD CVDVIITQQL PCEAEFVRSD PATTPTADGK LVWKIDRLGQ GEKSKITVWV
     KPLKEGCCFT AATVCACPEI RSVTKCGQPA ICVKQEGPEN ACLRCPVVYK INVVNQGTAT
     ARNVVVENPV PDSYAHSSGQ RVLTFTLGDM QPGEHRTITV EFCPLKRGRA TNIAMVSYCG
     GHKNTASVTT VINEPCVQVS IAGADWSYVC KPVEYVISVS NPGDLVLRDV VVKDTLSPGV
     TVLEAAGAQI SCNKVVWTVK ELNPGESLQY KVLVRAQTPG QFTNNVVVKS CSDCGTCTSC
     AEATTYWKGV AATHMCVVDT CDPVCVGENT VYRICVTNRG SAEDTNVSLM LKFSKELQPV
     SFSGPTKGTI TGNTVVFDSL PRLGSKETVE FSVTLKAVSA GDARGEAILS SDTLTVPVSD
     TENTHIY