ID   OMCB_CHLTJ              Reviewed;         547 AA.
AC   C4PRC1; P18151;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-NOV-2009, sequence version 2.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Large cysteine-rich periplasmic protein OmcB;
DE            Short=Large-CRP;
DE   AltName: Full=60 kDa cysteine-rich OMP;
DE   AltName: Full=60 kDa outer membrane protein;
DE   AltName: Full=Cysteine-rich outer membrane protein;
DE            Short=CRP;
DE   Flags: Precursor;
GN   Name=omcB; OrderedLocusNames=JALI_4441;
OS   Chlamydia trachomatis serovar B (strain Jali20/OT).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=580049;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2612891; DOI=10.1016/0378-1097(89)90233-4;
RA   Watson M.W., Lambden P.R., Ward M.E., Clarke I.N.;
RT   "Chlamydia trachomatis 60 kDa cysteine rich outer membrane protein:
RT   sequence homology between trachoma and LGV biovars.";
RL   FEMS Microbiol. Lett. 53:293-297(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Jali20/OT;
RX   PubMed=19460133; DOI=10.1186/1471-2164-10-239;
RA   Seth-Smith H.M.B., Harris S.R., Persson K., Marsh P., Barron A.,
RA   Bignell A., Bjartling C., Clark L., Cutcliffe L.T., Lambden P.R.,
RA   Lennard N., Lockey S.J., Quail M.A., Salim O., Skilton R.J., Wang Y.,
RA   Holland M.J., Parkhill J., Thomson N.R., Clarke I.N.;
RT   "Co-evolution of genomes and plasmids within Chlamydia trachomatis and the
RT   emergence in Sweden of a new variant strain.";
RL   BMC Genomics 10:239-239(2009).
CC   -!- FUNCTION: In elementary bodies (EBs, the infectious stage, which is
CC       able to survive outside the host cell) provides the structural
CC       integrity of the outer envelope through disulfide cross-links with the
CC       small cysteine-rich protein and the major outer membrane protein. It
CC       has been described in publications as the Sarkosyl-insoluble COMC
CC       (Chlamydia outer membrane complex), and serves as the functional
CC       equivalent of peptidoglycan (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of a disulfide cross-linked outer membrane complex (COMC)
CC       composed of the major outer membrane porin (MOMP), the small cysteine-
CC       rich protein (OmcA) and the large cysteine-rich periplasmic protein
CC       (OmcB). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305}.
CC   -!- CAUTION: Was thought to be an outer membrane protein as it is part of a
CC       disulfide cross-linked complex that is insoluble in the detergent
CC       Sarkosyl; however based on experiments in C.psittaci it is likely to be
CC       periplasmic. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAX10898.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; X53510; CAA37588.1; -; Genomic_DNA.
DR   EMBL; FM872308; CAX10898.1; ALT_INIT; Genomic_DNA.
DR   PIR; D71515; D71515.
DR   RefSeq; WP_009872660.1; NC_012686.1.
DR   AlphaFoldDB; C4PRC1; -.
DR   KEGG; ctj:JALI_4441; -.
DR   HOGENOM; CLU_029611_0_0_0; -.
DR   OMA; CEAEFVS; -.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR003506; Chlam_OMP6.
DR   InterPro; IPR001434; DUF11.
DR   InterPro; IPR013783; Ig-like_fold.
DR   Pfam; PF03504; Chlam_OMP6; 1.
DR   Pfam; PF01345; DUF11; 3.
DR   PRINTS; PR01336; CHLAMIDIAOM6.
DR   TIGRFAMs; TIGR01451; B_ant_repeat; 2.
PE   3: Inferred from homology;
KW   Cell shape; Disulfide bond; Periplasm; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..40
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000389549"
FT   CHAIN           41..547
FT                   /note="Large cysteine-rich periplasmic protein OmcB"
FT                   /id="PRO_0000389550"
FT   REGION          45..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..77
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   547 AA;  58694 MW;  42719B4BDCEDCCEA CRC64;
     MNKLIRRAVT IFAVTSVASL FASGVLETSM AESLSTNVIS LADTKAKDNT SHKSKKARKN
     HSKETPVDRK EVAPVHESKA TGPKQDSCFG RMYTVKVNDD RNVEITQAVP EYATVGSPYP
     IEITATGKRD CVDVIITQQL PCEAEFVRSD PATTPTADGK LVWKIDRLGQ GEKSKITVWV
     KPLKEGCCFT AATVCACPEI RSVTKCGQPA ICVKQEGPEN ACLRCPVVYK INIVNQGTAT
     ARNVVVENPV PDGYAHSSGQ RVLTFTLGDM QPGEHRTITV EFCPLKRGRA TNIATVSYCG
     GHKNTASVTT VINEPCVQVS IAGADWSYVC KPVEYVISVS NPGDLVLRDV VVEDTLSPGV
     TVLEAAGAQI SCNKVVWTVK ELNPGESLQY KVLVRAQTPG QFTNNVVVKS CSDCGTCTSC
     AEATTYWKGV AATHMCVVDT CDPVCVGENT VYRICVTNRG SAEDTNVSLM LKFSKELQPV
     SFSGPTKGTI TGNTVVFDSL PRLGSKETVE FSVTLKAVSA GDARGEAILS SDTLTVPVSD
     TENTHIY